Protein Alignment CG10669 and ZNF585A

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: NP_001275729.1
• Gene: ZNF585A / 199704
• HGNCID: 26305
• Length: 769
• Species: Homo sapiens
• Alignment Length: 954
• Identity: 212/954 - (22%)
• Similarity: 325/954 - (34%)
• Gaps: 294/954 - (30%)

  Fly    27 KTFVQLL---VELTRIEVVMAQAEKFPQWLCYACAEKLESTYDFVLQARRTHE------LW---- 78
            :|:..||   .::...||||.:..|.| |               .||..|..:      ||
Human    58 ETYSHLLSVGYQVPEAEVVMLEQGKEP-W---------------ALQGERPRQSCPGEKLWDHNQ 106

  Fly    79 LQKIGD----SLNGDDEMEGTAALECLR---------ETPIHLFEIEGVTIKTEELASTQQAPKA 130
            .:||..    |........|..|.||.:         :..:||..:.|     |:|....:..||
Human   107 CRKILSYKQVSSQPQKMYPGEKAYECAKFEKIFTQKSQLKVHLKVLAG-----EKLYVCIECGKA 166

  Fly   131 DPLVRPRIVKRSIVHFSDSDEDLDDVPLRQRKIAASVCGSDTTKENVCELCNKVFRYVTNLYRHK 195
            . :.:|..:.....|..:.       |.:                  |..|.|.|..|::|:||
Human   167 F-VQKPEFIIHQKTHMREK-------PFK------------------CNECGKSFFQVSSLFRH- 204

  Fly   196 QRDHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANP 260
            ||.|     .|    |..|:|..|.|.:.|...|..|: |.|        :|.:....
Human   205 QRIH-----TG----EKLYECSQCGKGFSYNSDLSIHE-KIH--------TGERHHEC------- 244

  Fly   261 YSPASISETSTNQSRTNNDSL-VHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHKH 324
                    |...::.|...:| :|..|          |:||.||. |.:|.:::.....||.|:
Human   245 --------TDCGKAFTQKSTLKMHQKI----------HTGERSYI-CIECGQAFIQKTHLIAHR- 289

  Fly   325 KEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVD-------GFDF--------HRSE 374
            :.|..::.|:.|:       ...|..:.:......|::.||.       |..|        |:..
Human   290 RIHTGEKPYECSN-------CGKSFISKSQLQVHQRVHTRVKPYICTEYGKVFSNNSNLVTHKKV 347

  Fly   375 PNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRI 439
            .:..|...|..|.:.||...||..|.:.|..:..:|         .....|...:.:|..:.:||
Human   348 QSREKSSICTECGKAFTYRSELIIHQRIHTGEKPYE---------CSDCGKAFTQKSALTVHQRI 403

  Fly   440 FRDLRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLH 504
            ...                                       .:||.|..|.       ..::..
Human   404 HTG---------------------------------------EKSYICMKCG-------LAFIQK 422

  Fly   505 QH---HQKEHTWLDAPHVCQRCDSRFLN-LQLLKH---HTSQLCQNTLKRFMCDKCPQRFFWRRN 562
            .|   ||..||. :.||.|..|...|.: .||..|   ||.:      |.:||:||.:.|..|.|
Human   423 AHLIAHQIIHTG-EKPHKCGHCGKLFTSKSQLHVHKRIHTGE------KPYMCNKCGKAFTNRSN 480

  Fly   563 LRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHL 627
            |..|...| ..::||.|.:|.::|..:|.:..|:.:...:...|   |..|.:.|.:.:.|..|.
Human   481 LITHQKTH-TGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYE---CNTCGKAFTQKSHLNIHQ 541

  Fly   628 QRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTA 692
            :.|                    .|.:..:|..|...|                :|.|..::...
Human   542 KIH--------------------TGERQYECHECGKAF----------------NQKSILIVHQK 570

  Fly   693 TGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC--IFKTVD 755
            .              .|..:.|.|..|...|.|:.....|| .:|:.:| |:.|..|  .|.:..
Human   571 I--------------HTGEKPYVCTECGRAFIRKSNFITHQ-RIHTGEK-PYECSDCGKSFTSKS 619

  Fly   756 KNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQC 820
            :.::||.:.|    .||.:.|..||..|....||::|..|...::|                |.|
Human   620 QLLVHQPVHT----GEKPYVCAECGKAFSGRSNLSKHQKTHTGEKP----------------YIC 664

  Fly   821 PHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCD 885
            ..|.::|..:..|..|.| :|..:    |.|.||.||......::|.:|.|.||||||:.|..|.
Human   665 SECGKTFRQKSELITHHR-IHTGE----KPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCAECG 724

  Fly   886 MRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            ..||....|..|:..|||::||:|..|.|.|.:......|...|
Human   725 KAFTDRSNLNKHQTTHTGDKPYKCGICGKGFVQKSVFSVHQSSH 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262	15/65 (23%)
		C2H2 Zn finger	178..199	CDD:275368	10/20 (50%)
		C2H2 Zn finger	216..233	CDD:275368	5/16 (31%)
		C2H2 Zn finger	520..542	CDD:275368	8/25 (32%)
		C2H2 Zn finger	550..570	CDD:275368	8/19 (42%)
		C2H2 Zn finger	579..600	CDD:275368	5/20 (25%)
		C2H2 Zn finger	610..630	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	5/21 (24%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	7/19 (37%)
		zf-H2C2_2	866..889	CDD:463886	11/22 (50%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:463886	11/24 (46%)
		C2H2 Zn finger	909..929	CDD:275368	5/19 (26%)
ZNF585A	NP_001275729.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630	9/27 (33%)
		C2H2 Zn finger	132..152	CDD:275368	3/19 (16%)
		C2H2 Zn finger	160..180	CDD:275368	3/20 (15%)
		COG5048	184..529	CDD:227381	103/488 (21%)
		C2H2 Zn finger	188..208	CDD:275368	10/20 (50%)
		C2H2 Zn finger	216..236	CDD:275368	7/20 (35%)
		C2H2 Zn finger	244..264	CDD:275368	5/44 (11%)
		C2H2 Zn finger	272..292	CDD:275368	5/20 (25%)
		C2H2 Zn finger	300..320	CDD:275368	3/26 (12%)
		C2H2 Zn finger	328..347	CDD:275370	3/18 (17%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..404	CDD:275368	3/19 (16%)
		C2H2 Zn finger	412..432	CDD:275368	5/26 (19%)
		C2H2 Zn finger	440..460	CDD:275368	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		COG5048	476..768	CDD:227381	92/372 (25%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		C2H2 Zn finger	552..572	CDD:275368	5/49 (10%)
		C2H2 Zn finger	580..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	608..628	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	7/19 (37%)
		C2H2 Zn finger	664..684	CDD:275368	6/20 (30%)
		C2H2 Zn finger	692..712	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	748..768	CDD:275368	5/19 (26%)