Protein Alignment CG10669 and ZNF782

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: NP_001001662.1
• Gene: ZNF782 / 158431
• HGNCID: 33110
• Length: 699
• Species: Homo sapiens
• Alignment Length: 886
• Identity: 194/886 - (21%)
• Similarity: 312/886 - (35%)
• Gaps: 237/886 - (26%)

  Fly    74 THELWLQKIGDSLNGDDEMEGTAALECLRETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPR- 137
            :.|.| |.:|       .:|.|...:.:.|...||..:.....|.|.:.:.:|.  .||.:..:
Human    18 SQEEW-QHMG-------PVERTLYRDVMLENYSHLVSVGYCFTKPELIFTLEQG--EDPWLLEKE 72

  Fly   138 --IVKRSIVHFSDSDEDLDDVPLRQRKIAASVCGSD---TTKENVCELCNKVFRYVTNLYRHKQR 197
              .:.|:....|..||..:..|..|.|....|..::   ||::   |:..|......|::|.:..
Human    73 KGFLSRNSPEDSQPDEISEKSPENQGKHLLQVLFTNKLLTTEQ---EISGKPHNRDINIFRARMM 134

  Fly   198 DHGILGKNGEDYEEDYYKCDLCDKTYKYVMALVKH----KHKEHGSS-----LLSNNSGRKMPST 253
            .               .|||:.....:.:..:..|    |.|.|..:     |:|...||   :.
Human   135 P---------------CKCDIAGSACQGLSLMAPHCQYSKEKAHERNVCDKWLISIKDGR---TN 181

  Fly   254 LAEDANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVS 318
            ..|.:..||  .|.:|..::    .:.:.|..|:.:         |:|..||  :..|::....:
Human   182 TQEKSFAYS--KIVKTLHHK----EEVIQHQTIQTL---------GQDFEYN--ESRKAFLEKAA 229

  Fly   319 LIKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDF-----------HR 372
            |:. .:..|...:||..:...:::...||...       |..:|.....::|           |:
Human   230 LVT-SNSTHPKGKSYNFNKFGENKYDKSTFII-------PQNMNPEKSHYEFNDTGNCFCRITHK 286

  Fly   373 SEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKR 437
            :...|          :.|::...:|.|.:.|.....|| :|:...|          .||....:|
Human   287 TLTGG----------KSFSQKSHIREHHRVHIGVKPFE-YGKSFNR----------NSTLPVHQR 330

  Fly   438 RIFRDLRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYL 502
            ....|    .|..|:..|....|:.|...
Human   331 THATD----KYSDYHPCTETFSYQSTFSV------------------------------------ 355

  Fly   503 LHQHHQKEHTWLDAPHVCQRC-DSRFLNLQLL---KHHTSQLCQNTLKRFMCDKCPQRFFWRRNL 563
                |||.|. ...|:....| .|..:|..|:   |.||.:      |.:.|.:|.:.|..:..|
Human   356 ----HQKVHI-RAKPYEYNECGKSCSMNSHLIWPQKSHTGE------KPYECPECGKAFSEKSRL 409

  Fly   564 RAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQ 628
            |.|...| ..::.|.||.|.::|..||.:..|:.....:...|   |..|.::|...::|..|.:
Human   410 RKHQRTH-TGEKPYKCDGCDKAFSAKSGLRIHQRTHTGEKPFE---CHECGKSFNYKSILIVHQR 470

  Fly   629 RHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTAT 693
            .|                    .|.|..:|..|...|..::.||.|  .:.|
Human   471 TH--------------------TGEKPFECNECGKSFSHMSGLRNH--RRTH------------- 500

  Fly   694 GFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNM 758
                           |..|.|.||.|...|:.:..:.:| :..|:.:| |:.|..|......|:.
Human   501 ---------------TGERPYKCDECGKAFKLKSGLRKH-HRTHTGEK-PYKCNQCGKAFGQKSQ 548

  Fly   759 LHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHC 823
            |..|.|..  ..||.:.|..||..|..:.||..|..|...::|                |||..|
Human   549 LRGHHRIH--TGEKPYKCNHCGEAFSQKSNLRVHHRTHTGEKP----------------YQCEEC 595

  Fly   824 WRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRF 888
            .::|..:.:|..|.| .|..:    |.|.|:.||......:.|..|.|.||||||:.|:.|...|
Human   596 GKTFRQKSNLRGHQR-THTGE----KPYECNECGKAFSEKSVLRKHQRTHTGEKPYNCNQCGEAF 655

  Fly   889 TVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            :....|:||:|.||||:||:|..|.:.|::...||.|...|
Human   656 SQKSNLRVHQRTHTGEKPYKCDKCGRTFSQKSSLREHQKAH 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262	2/5 (40%)
		C2H2 Zn finger	178..199	CDD:275368	4/20 (20%)
		C2H2 Zn finger	216..233	CDD:275368	3/20 (15%)
		C2H2 Zn finger	520..542	CDD:275368	7/25 (28%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	5/19 (26%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	6/19 (32%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:463886	11/22 (50%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:463886	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	6/19 (32%)
ZNF782	NP_001001662.1	KRAB	8..67	CDD:214630	13/58 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..95		4/19 (21%)
		C2H2 Zn finger	291..307	CDD:275368	4/25 (16%)
		C2H2 Zn finger	314..332	CDD:275368	6/28 (21%)
		C2H2 Zn finger	343..360	CDD:275368	6/56 (11%)
		C2H2 Zn finger	369..388	CDD:275368	5/18 (28%)
		COG5048	392..697	CDD:227381	103/384 (27%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/21 (29%)
		C2H2 Zn finger	508..528	CDD:275368	5/20 (25%)
		C2H2 Zn finger	536..556	CDD:275368	6/19 (32%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		C2H2 Zn finger	592..612	CDD:275368	6/20 (30%)
		C2H2 Zn finger	620..640	CDD:275368	6/19 (32%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)