DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and Ctcf

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	XP_030099140.1	Gene:	Ctcf / 13018	MGIID:	109447	Length:	745	Species:	Mus musculus

Alignment Length:	364	Identity:	89/364 - (24%)
Similarity:	142/364 - (39%)	Gaps:	73/364 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 VEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGF 632
            ::.|..::::.|:.||.:...:|.:.:| :..|.|....  .|..|.|.|....||..||..|
Mouse   266 IKKKGVKKTFQCELCSYTCPRRSNLDRH-MKSHTDERPH--KCHLCGRAFRTVTLLRNHLNTH-- 325

  Fly   633 TGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFEL 697
                              .|.:..:|..||:.||:..:|.||...:...::|
Mouse   326 ------------------TGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKP------------- 359

  Fly   698 LLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQH 762
                            :.|.:||.......::..|..| |:.:: |..|..|.:.:.|...|.:|
Mouse   360 ----------------FKCSMCDYASVEVSKLKRHIRS-HTGER-PFQCSLCSYASRDTYKLKRH 406

  Fly   763 LRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSF 827
            :||.  :.||.:.|..|..:|.....:..|:..:|::..|              ::.||||....
Mouse   407 MRTH--SGEKPYECYICHARFTQSGTMKMHILQKHTENVA--------------KFHCPHCDTVI 455

  Fly   828 VVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHY 892
            ..:..|..|:|..| :....|||  |..|.........|..|.:.|..||.||||.||.......
Mouse   456 ARKSDLGVHLRKQH-SYIEQGKK--CRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQER 517

  Fly   893 ELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHND 931
            .:.:|:|.||||:||.|:.|||.|.:...|..|...::|
Mouse   518 HMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368
		C2H2 Zn finger	550..570	CDD:275368	0/1 (0%)
		C2H2 Zn finger	579..600	CDD:275368	5/20 (25%)
		C2H2 Zn finger	610..630	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..737	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	6/19 (32%)
		C2H2 Zn finger	776..795	CDD:275368	4/18 (22%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	4/19 (21%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	22/52 (42%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
Ctcf	XP_030099140.1	zf-H2C2_5	275..298	CDD:372805	5/23 (22%)
		C2H2 Zn finger	277..297	CDD:275368	5/20 (25%)
		zf-H2C2_2	289..314	CDD:372612	7/27 (26%)
		C2H2 Zn finger	305..325	CDD:275368	8/19 (42%)
		zf-H2C2_2	318..342	CDD:372612	9/43 (21%)
		C2H2 Zn finger	333..356	CDD:275368	8/22 (36%)
		zf-H2C2_5	360..384	CDD:372805	6/24 (25%)
		C2H2 Zn finger	362..382	CDD:275368	5/20 (25%)
		COG5048	<375..509	CDD:227381	41/154 (27%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	418..435	CDD:275368	3/16 (19%)
		C2H2 Zn finger	448..466	CDD:275368	6/17 (35%)
		C2H2 Zn finger	478..498	CDD:275368	4/19 (21%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		zf-H2C2_2	518..543	CDD:372612	13/24 (54%)
		C2H2 Zn finger	534..555	CDD:275368	7/20 (35%)
		C2H2 Zn finger	566..582	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100