DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and ZNF648

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001009992.1	Gene:	ZNF648 / 127665	HGNCID:	18190	Length:	568	Species:	Homo sapiens

Alignment Length:	751	Identity:	151/751 - (20%)
Similarity:	233/751 - (31%)	Gaps:	286/751 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 DANPYSPASISETSTNQSRTNNDSLVHSIIKAVVLSDEDGHSGE-DSYYNCDQCSKSYKYIVSLI 320
            :|:|.|..:.....|.....|.:|           .||||...| :...:...|.:.    .|.:
Human    12 EASPLSSLTEEAHDTQMLSMNLES-----------DDEDGGEAEKEGTADPVACPRG----SSPV 61

  Fly   321 KHKHKE----H-LDKESYKQSDDED-----------------DRPLASTSASASAPTAK------ 357
            .|::.:    | |.||..|.||...                 .|.:...:.:..:|.|.
Human    62 THENPDLPWPHPLGKEEEKFSDSSSAGGMGQKPVEMSGKASWSRDVTKINETQGSPGASRALGSL 126

  Fly   358 PSRINRRV---------------DGF---------DFHRSEPNGAKEI------------KCMIC 386
            ||.:..::               ||:         |...|.|:..|.:            ..::|
Human   127 PSGLAHKLLGQMQPLGDRLPAGDDGYSGANQDAVLDVPPSFPSNGKYLCAHKSVDTSAGNSSLLC 191

  Fly   387 LRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKT----AVESTA---EG--LKRRIFRD 442
            ..|.....:|.....:.|.    :|...|....|....|.    .|::.|   ||  .:.|.:|.
Human   192 FPRPGSNWDLPTQETHTPA----QASATPASLAAAVLAKARNSRKVQNQAGRREGGEAEARPYRC 252

  Fly   443 LRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLH--- 504
            ||.|          :|..:.:...|..::.|..      .:.|:||||.        |...|
Human   253 LRGG----------RAFQKPSKPLSPAETRGGA------AKRYACELCG--------KAYSHRGT 293

  Fly   505 -QHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLV 568
             |.|::.||. :.|:.|..||                              :.:.|..:.|.|:.
Human   294 LQQHRRLHTG-ERPYQCSFCD------------------------------KAYTWSSDHRKHIR 327

  Fly   569 EHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFT 633
            .| ..::.|||..|.::|...|.:.||:..||  ||.:..||..|..||.:|..|.:|.:.|
Human   328 TH-TGEKPYPCPDCGKAFVRSSDLRKHQRNMH--SNNKPFPCSECGLTFNKPLSLLRHQRTH--- 386

  Fly   634 GQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELL 698
                             .|.|..:|..||.:|...:.:..|  .:.||.:
Human   387 -----------------LGAKPFRCPACDREFAVASRMVEH--QRVHSGE--------------- 417

  Fly   699 LDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHL 763
                         |.:.|..|...|.:...:|||| :||:
Human   418 -------------RPFPCPTCGKCFTKSSNLSEHQ-TLHT------------------------- 443

  Fly   764 RTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFV 828
                  .::.|.|..||..|.....|.:|......::|                :.|..|.::|.
Human   444 ------GQRPFKCADCGVAFAQPSRLVRHQRIHTGERP----------------FPCTQCGQAFA 486

  Fly   829 VQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYE 893
            ...:|.:                                 |.:.|:|||.|.|..|...|.:..|
Human   487 RSSTLKR---------------------------------HQQIHSGEKGFLCAECGRAFRIASE 518

  Fly   894 LKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMH 929
            |..|.|.|.|||||||..|.:.|.|.:.|:||...|
Human   519 LAQHIRMHNGERPYQCEDCGQAFTRSNHLQRHRAKH 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368	3/21 (14%)
		C2H2 Zn finger	550..570	CDD:275368	3/19 (16%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..737	CDD:275368	7/20 (35%)
		C2H2 Zn finger	746..766	CDD:275368	0/19 (0%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	4/17 (24%)
		C2H2 Zn finger	853..873	CDD:275368	1/19 (5%)
		zf-H2C2_2	866..889	CDD:290200	8/22 (36%)
		COG5048	877..>930	CDD:227381	24/53 (45%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	14/24 (58%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
ZNF648	NP_001009992.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106		21/108 (19%)
		C2H2 Zn finger	281..301	CDD:275368	8/27 (30%)
		zf-H2C2_2	294..317	CDD:316026	8/53 (15%)
		COG5048	<307..494	CDD:227381	59/350 (17%)
		C2H2 Zn finger	309..329	CDD:275368	6/49 (12%)
		C2H2 Zn finger	337..355	CDD:275368	6/17 (35%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	5/21 (24%)
		C2H2 Zn finger	422..442	CDD:275368	7/20 (35%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	5/52 (10%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	518..543	CDD:316026	14/24 (58%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..568		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930