DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and ZNF268

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	968	Identity:	219/968 - (22%)
Similarity:	347/968 - (35%)	Gaps:	237/968 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EVVMAQAEKFPQWLCYACAEKLESTYDFVLQARRTHELWLQKIGDSLNGDDEMEGTA-ALECL-- 101
            |:.|.||: .|...|.....|::...|           |.|:      ..|::..|| :.||.
Human   138 ELCMVQAQ-VPNQTCPNTVWKIDDLMD-----------WHQE------NKDKLGSTAKSFECTTF 184

  Fly   102 ------------RETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIVKRSIVHFSDSDEDLD 154
                        |:.| |.....|.::|..:..|.......:..   ::..:|..|...
Human   185 GKLCLLSTKYLSRQKP-HKCGTHGKSLKYIDFTSDYARNNPNGF---QVHGKSFFHSKH------ 239

  Fly   155 DVPLRQRKIAASVCGSDTTKENV-------------------CELCNKVFRYVTNLYRHKQRDHG 200
                .|..|....|.|..:.:.|                   |..|.|.|...:.|..| |:.|.
Human   240 ----EQTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVH-QQTHA 299

  Fly   201 ILGKNGEDYEEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRK---------MPSTLAE 256
                     ||..|.|:.|.|.:.....|:.|:....|..|...:..||         :...:..
Human   300 ---------EEKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHT 355

  Fly   257 DANPYSPASISETSTNQSRTNNDSLVHS--------------IIKAVVLSDEDGHSGEDSYYNCD 307
            ..|||......:..:.:.:..:....||              .:|:.::..|..|:||.. |.|:
Human   356 GENPYECCECGKVFSRKDQLVSHQKTHSGQKPYVCNECGKAFGLKSQLIIHERIHTGEKP-YECN 419

  Fly   308 QCSKSYKYIVSLIKHKHKEHLDKESYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHR 372
            :|.|::....:|:.|: :.|..::.|..||            ...|.|.|...|        .|:
Human   420 ECQKAFNTKSNLMVHQ-RTHTGEKPYVCSD------------CGKAFTFKSQLI--------VHQ 463

  Fly   373 SEPNGAKEIKCMICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKR 437
            ....|.|...|:.|.:.|:...:|..|.::|                             .|:|.
Human   464 GIHTGVKPYGCIQCGKGFSLKSQLIVHQRSH-----------------------------TGMKP 499

  Fly   438 RIFRDLRMGVYGRYYSITNQARY--EMTLDSSDTDSDGDGDDNVVIRR-------SYSCELCDSP 493
            .:..:.......:.|.|.:...:  |...:.::..........::|.:       .|.|..|..
Human   500 YVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGK- 563

  Fly   494 EARWPRKYLLHQHHQKEHTWLDAPHVCQRCDSRF-LNLQLLKH---HTSQLCQNTLKRFMCDKCP 554
              .:.|||.|.. ||:.|.. :.|:.|..|...| |..||:.|   ||.:      |.|.|.:|.
Human   564 --AFSRKYQLIS-HQRTHAG-EKPYECTDCGKAFGLKSQLIIHQRTHTGE------KPFECSECQ 618

  Fly   555 QRFFWRRNLRAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLP--CRWCTRTF 617
            :.|..:.||..|...| ..::.|.|::|.::|..||     :|::|:..:..:.|  |..|.:||
Human   619 KAFNTKSNLIVHQRTH-TGEKPYSCNECGKAFTFKS-----QLIVHKGVHTGVKPYGCSQCAKTF 677

  Fly   618 YRPALLYKHLQRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVS----VADLRRHISMQ 678
            ...:.|..|.:.|  ||             .||.|     |..|...|.|    :..:|.|...:
Human   678 SLKSQLIVHQRSH--TG-------------VKPYG-----CSECGKAFRSKSYLIIHMRTHTGEK 722

  Fly   679 GHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLP 743
            .|..:......|..:  :|::.....:.|    ..|.|..|...|.|:.::..||.: |:.:| |
Human   723 PHECRECGKSFSFNS--QLIVHQRIHTGE----NPYECSECGKAFNRKDQLISHQRT-HAGEK-P 779

  Fly   744 HNCEHCIFKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQP 808
            :.|..|......|:.|..|:||.  :.||.:.|..||..|:|:..|..|..|.....|
Human   780 YGCSECGKAFSSKSYLIIHMRTH--SGEKPYECNECGKAFIWKSLLIVHERTHAGVNP------- 835

  Fly   809 PLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRH 873
                     |:|..|.:||..:..|..|.| ||..:    |.|.||.||...:..::|.:|.|.|
Human   836 ---------YKCSQCEKSFSGKLRLLVHQR-MHTRE----KPYECSECGKAFIRNSQLIVHQRTH 886

  Fly   874 TGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHND 931
            :||||:.|:.|...|:....|..|:|.||||:|.:||.|.|.|....:|..|...|.|
Human   887 SGEKPYGCNECGKTFSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHVD 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	9/40 (23%)
		C2H2 Zn finger	178..199	CDD:275368	7/20 (35%)
		C2H2 Zn finger	216..233	CDD:275368	4/16 (25%)
		C2H2 Zn finger	520..542	CDD:275368	9/25 (36%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	6/19 (32%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	7/19 (37%)
		zf-H2C2_2	866..889	CDD:290200	10/22 (45%)
		COG5048	877..>930	CDD:227381	20/52 (38%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630	1/2 (50%)
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368	7/20 (35%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..354	CDD:275368	2/19 (11%)
		zf-H2C2_2	347..371	CDD:290200	3/23 (13%)
		C2H2 Zn finger	362..382	CDD:275368	0/19 (0%)
		zf-H2C2_2	375..397	CDD:290200	2/21 (10%)
		C2H2 Zn finger	390..410	CDD:275368	2/19 (11%)
		zf-H2C2_2	403..427	CDD:290200	8/24 (33%)
		C2H2 Zn finger	418..438	CDD:275368	5/20 (25%)
		zf-H2C2_2	430..454	CDD:290200	7/36 (19%)
		C2H2 Zn finger	446..466	CDD:275368	7/39 (18%)
		C2H2 Zn finger	474..494	CDD:275368	5/19 (26%)
		COG5048	497..910	CDD:227381	121/480 (25%)
		C2H2 Zn finger	502..522	CDD:275368	2/19 (11%)
		C2H2 Zn finger	530..550	CDD:275368	1/19 (5%)
		zf-H2C2_2	543..567	CDD:290200	4/26 (15%)
		zf-C2H2	556..578	CDD:278523	9/25 (36%)
		C2H2 Zn finger	558..578	CDD:275368	8/23 (35%)
		C2H2 Zn finger	586..606	CDD:275368	7/19 (37%)
		zf-H2C2_2	599..623	CDD:290200	9/29 (31%)
		C2H2 Zn finger	614..634	CDD:275368	6/19 (32%)
		zf-H2C2_2	626..650	CDD:290200	7/24 (29%)
		C2H2 Zn finger	642..662	CDD:275368	7/24 (29%)
		C2H2 Zn finger	670..690	CDD:275368	6/19 (32%)
		C2H2 Zn finger	698..718	CDD:275368	5/19 (26%)
		zf-H2C2_2	710..734	CDD:290200	3/23 (13%)
		C2H2 Zn finger	726..746	CDD:275368	2/21 (10%)
		zf-H2C2_2	739..763	CDD:290200	6/27 (22%)
		C2H2 Zn finger	754..774	CDD:275368	6/20 (30%)
		C2H2 Zn finger	782..802	CDD:275368	6/19 (32%)
		zf-H2C2_2	794..817	CDD:290200	9/24 (38%)
		C2H2 Zn finger	810..830	CDD:275368	7/19 (37%)
		C2H2 Zn finger	838..858	CDD:275368	7/20 (35%)
		zf-H2C2_2	851..875	CDD:290200	11/28 (39%)
		C2H2 Zn finger	866..886	CDD:275368	7/19 (37%)
		C2H2 Zn finger	894..914	CDD:275368	6/19 (32%)
		zf-H2C2_2	907..929	CDD:290200	12/21 (57%)
		C2H2 Zn finger	922..942	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010