DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10669 and si:ch73-347e22.4

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	XP_003200604.2	Gene:	si:ch73-347e22.4 / 100536830	ZFINID:	ZDB-GENE-140106-269	Length:	2461	Species:	Danio rerio

Alignment Length:	1109	Identity:	226/1109 - (20%)
Similarity:	377/1109 - (33%)	Gaps:	292/1109 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VEKYAEKTFVQLLVELTRIEVVMAQAEKFPQWLCYACAEKLESTYDFVL----------QARRTH 75
            ::::.|...:.|..:||:...:...       :.:..||..|....|::          :|::|.
Zfish  1130 LKEHTEHPPMSLGKDLTQSSCIKTD-------IVHETAESNEENQVFIINEPSPQSSPKKAKKTR 1187

  Fly    76 ELWLQKIGDSLNGDDEMEGTAALECLRETPIH------LFEIEGVTIKTEELASTQQAPKADPLV 134
                   |..|...:|:|.:.|||..:....|      :.|::...|| ..:.|.|.......:|
Zfish  1188 -------GKQLFNKEEIEQSIALEAAKSEDKHSDVASIIREVDSENIK-NTVGSQQPVEDGAVVV 1244

  Fly   135 RPRIVKR----SIVHFSDSDEDLDDVPLRQRKIAASVCGSDTTKE-----NVCELCNKVFRYVTN 190
            :...|:.    :::|...:.:.......:::|:...:......:|     .:.::.....|....
Zfish  1245 QNNTVEEETRITVLHAGKTPKTKSQKVGQKKKMLVVLLTQVKEEEMSDDDRIADITESHTRPGET 1309

  Fly   191 LYRHKQRDHGILGKNGEDYEE--------------DYYKCDL--------------CDKTYKYVM 227
            |:|..|...   ||:.:|.|:              |..||:.              |:...|
Zfish  1310 LFRTMQTTD---GKDQDDVEQKHGNSSSVKITEFSDINKCNTRLGETPTSPMDITDCEDQSK--- 1368

  Fly   228 ALVKHKHKEHGSSLLSNNSG--------RKMPSTLAEDANPYSPASISETSTNQ--------SRT 276
              |:.|.::.|...|:.|:.        .::..||   :||.......:.:|.:        .:.
Zfish  1369 --VEQKPRKRGRPTLNQNTDISDITERQARLGETL---SNPMQTTDCEDHNTEKRPRKRGRPPKK 1428

  Fly   277 NNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCS--KSYKYIVSLIKHKHKEHLDKESY------ 333
            ||.::|.    ...|.|....|.|.|.::..|.|  |:.....|.:..|..|.|.....
Zfish  1429 NNKNMVF----VAHLEDNPSSSVEISEFSSSQDSTEKTVNVAESSVMQKDVEFLKMGKVVEVENS 1489

  Fly   334 -----KQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKL 393
                 ||..::......||:...|..:..|.|           :.|.|..|.|:   .||..::|
Zfish  1490 VVRVTKQLGNDPSDSSRSTTDPLSQDSPSPKR-----------KKEKNIEKPIR---NLRVSSRL 1540

  Fly   394 REL---------RNHLQNHPTDFDFEAHGE---PIERIAEGF---FKTAVE-----------STA 432
            .|:         :..|..:.|:. |...|:   |:..:||..   .||.|:           ...
Zfish  1541 YEMSLKDSQKADKPSLSQNATEV-FNREGKTSLPMPGVAENLKLCEKTTVQDGMLANIKIENKAT 1604

  Fly   433 EGLKRRIFRDLRMGVYGRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARW 497
            :.:|||                 |:.|....:.:...|.........::::..:|:.|....
Zfish  1605 KVVKRR-----------------NRGRKRDRIKAPSLDQRLKSKPTEIVKKPLTCKYCGISF--- 1649

  Fly   498 PRKYLLHQHHQKEHTWLDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRN 562
             |....:..|::.||. |.|:.|:.|...|..|..||.|.....|:|  .|.|..|..||..:.:
Zfish  1650 -RHITAYTIHRRIHTG-DKPYKCKICGKTFAQLSKLKSHHIAHTQDT--SFPCPCCNHRFMQKED 1710

  Fly   563 L----RAHLVEHKCKQE---------------------SYPCDQCSRSFQDKSAVTKHKLMMHRD 602
            |    :.||.|.|...|                     :|.|..|.::|     |.:.||.:|..
Zfish  1711 LLCHFKVHLKESKANSEPQKDLRSKRNALSNESSEAANNYRCLICKKNF-----VNQDKLQIHMQ 1770

  Fly   603 SN-MEL-LPCRWCTRTFYRPALLYKHLQRH--------GFTGQDLPLAETLLADASKPAGPKSVQ 657
            :: ||. |.|:.|.:.|:.|:.|..|.:.|        ...|:.......|...:...||.....
Zfish  1771 THEMEKPLSCKDCGKNFWNPSSLTAHEKTHWPVKPYACSICGKGFNQLRALKKHSQNHAGETPFS 1835

  Fly   658 CKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYSCDLCDLN 722
            |..|...|..::.||.|.:.:....:.:....|...||  ::....|....|. ..:.|.:|...
Zfish  1836 CFHCSHAFSDLSALRMHQASKTCIARKNVEANSNIEGF--IVSQGVDGQVNTP-VFFKCQICKQL 1897

  Fly   723 FRRRREISEHQYSLH---SFDKLPHNCEHC--IFKTVDKNMLHQHLRTQCMNT-EKKFACMRCG- 780
            ||:     ..||:||   .....|:.|..|  .::| |..| :.|....|.:: |.|.    ||
Zfish  1898 FRK-----WCQYTLHLQTHTSSPPYICFSCGQCYET-DSEM-NVHCEVCCQSSGEDKI----CGT 1951

  Fly   781 -------------------------YKFMWEENLAQHLSTQHSKQPAVPEQ---QPPLRRKRR-- 815
                                     .|....|.||:.:...:.....:||.   |.|:...|.
Zfish  1952 SLSEITEGVSRSPQSLPSTGTRQNSQKQTSSEQLAEPVQRNNKVLKKLPETITIQSPITLPRNQL 2016

  Fly   816 -----------------FRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLESLTP 863
                             :.|:|..|.:.|....||..|:: .|.|    |.:|.|:.||....:.
Zfish  2017 PAPSEAISASTSSSPSLWNYKCSRCGQRFKQYKSLSVHLQ-THAA----GFRYTCTHCGQFFESW 2076

  Fly   864 NKLNIHMRRH-TGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRH-V 926
            :||.:|.||| ...:.|.|..|:::|......|.|...|.|..||.||.|.|.|.....|..| .
Zfish  2077 SKLWLHQRRHRLKSRGFSCSQCNLQFRFFSSFKEHMIAHAGHSPYVCTLCPKTFTEEASLHAHQC 2141

  Fly   927 FMHN 930
            ..||
Zfish  2142 VSHN 2145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071	10/69 (14%)
		C2H2 Zn finger	178..199	CDD:275368	4/20 (20%)
		C2H2 Zn finger	216..233	CDD:275368	4/30 (13%)
		C2H2 Zn finger	520..542	CDD:275368	7/21 (33%)
		C2H2 Zn finger	550..570	CDD:275368	7/23 (30%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	6/21 (29%)
		C2H2 Zn finger	776..795	CDD:275368	6/44 (14%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	7/19 (37%)
		zf-H2C2_2	866..889	CDD:290200	8/23 (35%)
		COG5048	877..>930	CDD:227381	17/53 (32%)
		C2H2 Zn finger	881..901	CDD:275368	5/19 (26%)
		zf-H2C2_2	893..918	CDD:290200	11/24 (46%)
		C2H2 Zn finger	909..929	CDD:275368	7/20 (35%)
si:ch73-347e22.4	XP_003200604.2	C2H2 Zn finger	1642..1662	CDD:275368	4/23 (17%)
		zf-H2C2_2	1658..1679	CDD:290200	8/21 (38%)
		C2H2 Zn finger	1670..1690	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1698..1718	CDD:275368	5/19 (26%)
		zf-C2H2	1750..1772	CDD:278523	8/26 (31%)
		C2H2 Zn finger	1752..1772	CDD:275368	7/24 (29%)
		zf-H2C2_2	1765..1789	CDD:290200	8/23 (35%)
		C2H2 Zn finger	1780..1800	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1808..1828	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1836..1853	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1891..1911	CDD:275368	8/24 (33%)
		C2H2 Zn finger	1919..1935	CDD:275368	5/17 (29%)
		zf-C2H2_8	2038..2119	CDD:292531	27/85 (32%)
		C2H2 Zn finger	2038..2058	CDD:275368	6/20 (30%)
		zf-C2H2	2064..2086	CDD:278523	8/21 (38%)
		C2H2 Zn finger	2066..2086	CDD:275368	7/19 (37%)
		C2H2 Zn finger	2095..2115	CDD:275368	5/19 (26%)
		C2H2 Zn finger	2123..2144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	2152..2172	CDD:275368
		C2H2 Zn finger	2180..2200	CDD:275368
		C2H2 Zn finger	2222..2242	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100