DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and Zfp648

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_001191837.1	Gene:	Zfp648 / 100503355	MGIID:	2685049	Length:	525	Species:	Mus musculus

Alignment Length:	691	Identity:	142/691 - (20%)
Similarity:	221/691 - (31%)	Gaps:	260/691 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 DEDGHSG--------EDSYYNCDQCSKSYKYIVSLIKHKHKEHLDKESYKQSDDEDDRP-LASTS 348
            :|||..|        .||.::...|.                           :|::.| ..|..
Mouse    29 EEDGRKGGSPGTQNNTDSQFDTQSCK---------------------------EEENWPECFSAG 66

  Fly   349 ASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKCMICLRRFTKLRE--------LRNHLQNHP- 404
            ..|..|...|.:.:             ||.|:...:..:|...||:|        |.:.:|..|
Mouse    67 CVAQKPGEMPGKTS-------------NGGKKASRITQIRDSPKLQEALGAPSRSLLHKVQIQPL 118

  Fly   405 -----TDFDFEAHGEPIERI------AEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQA 458
                 :|...:|:.:|...:      :.|:|:......|..|.:.              |:.:..
Mouse   119 RDSVGSDGGKKANKDPASEVPNSFLDSGGYFEAQNSVEASSLDKN--------------SLEHFP 169

  Fly   459 RYEMTLDSSDT-------------------DSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLH 504
            |.|.||..:.|                   ..:|.|.:...:.|      |.....:..:..:..
Mouse   170 RSESTLVQTPTIPASLLVKVRSSRKVQGQAGPEGSGQEEEGLDR------CVRAFQKSTKVQVPA 228

  Fly   505 QHHQKEHTWLDAPHVCQRCDSRFLNLQLLKH----HTSQLCQNTLKRFMCDKCPQRFFWRRNLRA 565
            :||..:      |:|||.|...:.:...|:.    ||.:      :.:.|..|.:.:.|..:.|.
Mouse   229 EHHGSK------PYVCQLCGKAYSHRSTLQQHRRLHTGE------RPYRCPFCDKAYTWSSDHRK 281

  Fly   566 HLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRH 630
            |:..| ..::.|.|..|.|:|...|.:.||:..||  ||.:..||..|..||.||..|.:|.:.|
Mouse   282 HIRTH-TGEKPYGCPDCGRAFVRSSDLRKHQRNMH--SNDKPFPCAQCGLTFNRPLSLLRHQRTH 343

  Fly   631 GFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGF 695
                                .|.|..:|..|..:| |||.
Mouse   344 --------------------LGAKPFRCSSCGREF-SVAS------------------------- 362

  Fly   696 ELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLH 760
                                            .:.||| .:||
Mouse   363 --------------------------------RMVEHQ-RVHS---------------------- 372

  Fly   761 QHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWR 825
                     .|:.|.|..||..|....||.:|.:....::|                ::|..|..
Mouse   373 ---------GERPFPCSTCGKCFTKSSNLQEHQTLHTGQRP----------------FKCTDCGV 412

  Fly   826 SFVVQPS-LDKHIRDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFT 889
            :| .||| |.:|.| :|..:    :.:.|:.||......:.|..|.:.|:|:|.|.|..|...|.
Mouse   413 TF-AQPSRLLRHQR-IHTGE----RPFPCAECGQAFARSSTLKRHQQIHSGDKDFLCAECGRAFR 471

  Fly   890 VHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHN 930
            :..||..|.|.|.|||||||..|.:.|.|...|:||...|:
Mouse   472 IASELAQHIRMHNGERPYQCEGCGQTFTRSSHLQRHQAKHD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368	6/25 (24%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..737	CDD:275368	3/20 (15%)
		C2H2 Zn finger	746..766	CDD:275368	0/19 (0%)
		C2H2 Zn finger	776..795	CDD:275368	7/18 (39%)
		C2H2 Zn finger	820..838	CDD:275368	8/18 (44%)
		C2H2 Zn finger	853..873	CDD:275368	5/19 (26%)
		zf-H2C2_2	866..889	CDD:290200	8/22 (36%)
		COG5048	877..>930	CDD:227381	23/52 (44%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	14/24 (58%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
Zfp648	NP_001191837.1	C2H2 Zn finger	238..258	CDD:275368	4/19 (21%)
		zf-H2C2_2	251..274	CDD:290200	5/28 (18%)
		COG5048	262..>508	CDD:227381	90/380 (24%)
		C2H2 Zn finger	266..286	CDD:275368	5/19 (26%)
		zf-H2C2_2	280..303	CDD:290200	8/23 (35%)
		C2H2 Zn finger	294..312	CDD:275368	7/17 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..359	CDD:290200	8/44 (18%)
		C2H2 Zn finger	351..371	CDD:275368	9/78 (12%)
		zf-H2C2_2	366..387	CDD:290200	10/52 (19%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	7/41 (17%)
		C2H2 Zn finger	407..427	CDD:275368	9/21 (43%)
		zf-H2C2_2	420..444	CDD:290200	7/28 (25%)
		C2H2 Zn finger	435..455	CDD:275368	5/19 (26%)
		zf-H2C2_2	448..470	CDD:290200	8/21 (38%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		zf-H2C2_2	475..500	CDD:290200	14/24 (58%)
		zf-C2H2	489..511	CDD:278523	9/21 (43%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930