DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and Zfp648

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	XP_008767911.2	Gene:	Zfp648 / 100362915	RGDID:	2323778	Length:	534	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	115/540 - (21%)
Similarity:	180/540 - (33%)	Gaps:	189/540 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 RNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVYGRYYSITNQARYE 461
            :|.|::.|.   ||:.......|..|.....|:  |:|                    :.:|:.:
  Rat   166 KNSLEHFPR---FESTPAQTSSIPAGLAAGLVK--AQG--------------------SRKAQGQ 205

  Fly   462 MTLDSSDTDSDGDGDDNVVIRRSY--SCELCDSPEARWPRKYLLHQHHQKEHTWLDAPHVCQRCD 524
            :..:.|..:.:|. |..|..||::  |.||..|.|.|..:                 |:|||.|.
  Rat   206 VGPEGSRQEEEGP-DRCVQGRRAFQKSSELQVSAEQRGIK-----------------PYVCQLCG 252

  Fly   525 SRFLNLQLLKH----HTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYPCDQCSRS 585
            ..:.:...|:.    ||.:      :.:.|..|.:.:.|..:.|.|:..| ..::.|.|..|.|:
  Rat   253 KAYSHRSTLQQHRRLHTGE------RPYRCPFCDKAYTWSSDHRKHIRTH-TGEKPYGCPDCGRA 310

  Fly   586 FQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETLLADASKP 650
            |...|.:.||:..||  ||.:..||..|..||.||..|.:|.:.|
  Rat   311 FVRSSDLRKHQRNMH--SNDKPFPCAQCGLTFNRPLSLLRHQRTH-------------------- 353

  Fly   651 AGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEETSGRTYS 715
            .|.|..:|..|..:|...:.:..|  .:.||.:                            |.:.
  Rat   354 LGAKPFRCSCCSREFSVASRMVEH--QRVHSGE----------------------------RPFP 388

  Fly   716 CDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQCMNTEKKFACMRCG 780
            |.:|...|.:...:.||| :||:                               .::.|.|..||
  Rat   389 CSICGKCFTKSSNLHEHQ-TLHT-------------------------------GQRPFKCADCG 421

  Fly   781 YKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHIRDMHVAKK 845
            ..|.....|.:|......::|                :.|..|.::|....:|.:
  Rat   422 VTFAQPSRLLRHQRIHTGERP----------------FPCAECGQAFARSSTLKR---------- 460

  Fly   846 NPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHTGERPYQCT 910
                                   |.:.|:|:|.|.|..|...|.:..||..|.|.|.|||||||.
  Rat   461 -----------------------HQQTHSGDKDFLCAECGRAFRIASELAQHIRMHNGERPYQCE 502

  Fly   911 FCDKDFARPDKLRRHVFMHN 930
            .|.:.|.|...|:||...|:
  Rat   503 GCGQTFTRSSHLQRHQAKHD 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368	6/25 (24%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	610..630	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	0/19 (0%)
		C2H2 Zn finger	776..795	CDD:275368	6/18 (33%)
		C2H2 Zn finger	820..838	CDD:275368	4/17 (24%)
		C2H2 Zn finger	853..873	CDD:275368	1/19 (5%)
		zf-H2C2_2	866..889	CDD:290200	7/22 (32%)
		COG5048	877..>930	CDD:227381	23/52 (44%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:290200	14/24 (58%)
		C2H2 Zn finger	909..929	CDD:275368	7/19 (37%)
Zfp648	XP_008767911.2	C2H2 Zn finger	221..240	CDD:275368	7/18 (39%)
		C2H2 Zn finger	248..268	CDD:275368	4/19 (21%)
		zf-H2C2_2	261..284	CDD:290200	5/28 (18%)
		COG5048	272..>518	CDD:227381	82/379 (22%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		zf-H2C2_2	290..313	CDD:290200	8/23 (35%)
		C2H2 Zn finger	304..322	CDD:275368	7/17 (41%)
		C2H2 Zn finger	333..353	CDD:275368	8/19 (42%)
		C2H2 Zn finger	361..381	CDD:275368	4/21 (19%)
		zf-H2C2_2	376..397	CDD:290200	6/50 (12%)
		zf-C2H2	387..409	CDD:278523	6/22 (27%)
		C2H2 Zn finger	389..409	CDD:275368	6/20 (30%)
		C2H2 Zn finger	417..437	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..454	CDD:290200	6/39 (15%)
		C2H2 Zn finger	445..465	CDD:275368	5/52 (10%)
		zf-H2C2_2	458..480	CDD:290200	8/54 (15%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		zf-H2C2_2	485..510	CDD:290200	14/24 (58%)
		zf-C2H2	499..521	CDD:278523	9/21 (43%)
		C2H2 Zn finger	501..521	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930