Protein Alignment CG10669 and Zfp945

DIOPT Version :10

• Sequence 1: NP_651388.1
• Gene: CG10669 / 43069
• FlyBaseID: FBgn0039329
• Length: 933
• Species: Drosophila melanogaster
• Sequence 2: XP_006228161.2
• Gene: Zfp945 / 100362641
• RGDID: 2324317
• Length: 901
• Species: Rattus norvegicus
• Alignment Length: 1002
• Identity: 215/1002 - (21%)
• Similarity: 338/1002 - (33%)
• Gaps: 293/1002 - (29%)

  Fly    12 DGRYWIETPVEKYAEKTFVQLLVELTRIEVVMAQAEKF--------------PQ----------- 51
            ||...::|||              |.||.|.:.:.|.:              ||
  Rat    90 DGEERVKTPV--------------LRRIPVFVPETETWRRAIRRMNSALVNDPQDLLTFKDVSVD 140

  Fly    52 -----WLCYACAEK-------LESTYD---FVLQAR---RTHELWLQK----------IGDSLNG 88
                 |.|...|::       ||: |:   ||...|   :.||:..::          |.:..|.
  Rat   141 FSQQEWECLDHAQRALYMDVMLEN-YNNLLFVENNRVCIKHHEVLDRETKYSASEHVNIEEKSNK 204

  Fly    89 DDEMEGTAALECLRETPIHLFEIEGVTIKTEELASTQQAPKADPLVRPRIV----------KRSI 143
            .:|. |....|..:.||....: |..:|::.....|:.|  .:|......|          :...
  Rat   205 SNEC-GRMIEESSKSTPCQTND-EDTSIESSNRHKTENA--REPCKYKDCVNSLNLCSITSQNQT 265

  Fly   144 VHFSDSDED---LDDVPLRQRKIA-ASVCGSDTTKENVCELCNKVFRYVTNLYRHKQRDHGILGK 204
            ||....:.:   .|.|.|...||. ..:.|.  .|.:.|....|.|:..::|.|| ||.|.
  Rat   266 VHIGMREHNKAQYDKVFLSNYKIVQKGINGG--MKSHKCRKSGKFFKVHSSLSRH-QRAHS---- 323

  Fly   205 NGEDYEEDYYKCDLCDKTYKYVMALVKHKHKEHGSSLLSNNSGRKMPSTLAEDANPYSPASISET 269
                 .|.:|||..|.|::.::..|..|....:|                   ..||......:.
  Rat   324 -----REKHYKCTKCSKSFLHLSHLKLHYKIHYG-------------------GYPYKCTECGKC 364

  Fly   270 STNQSRTNNDSLVHSIIKAVVLSDEDGHSGEDSYYNCDQCSKSYKYIVSLIKHK--HKEHLDKE- 331
            ..:.|.....:.:|.               |::.|.|..|.||:.......||:  |:..:..|
  Rat   365 FYHVSDFERHNRIHV---------------EENTYKCSFCGKSFICCSEFRKHQKIHEGEMLSEC 414

  Fly   332 -------------SYKQSDDEDDRPLASTSASASAPTAKPSRINRRVDGFDFHRSEPNGAKEIKC 383
                         .|...|...::.........:..|:...:|:.|:.         .|.|..||
  Rat   415 NQDARSICTFSCREYHYRDGIREKCFRCKECGKTLSTSSGLKIHHRIH---------TGEKPYKC 470

  Fly   384 MICLRRFTKLRELRNHLQNHPTDFDFEAHGEPIERIAEGFFKTAVESTAEGLKRRIFRDLRMGVY 448
            ..|.:.||:...||.|.:.|               ..|..||      .....:...:...:.::
  Rat   471 TECDKSFTQKSNLRMHQKIH---------------TGENTFK------CSDCNKCFTQKCLLRIH 514

  Fly   449 GRYYSITNQARYEMTLDSSDTDSDGDGDDNVVIRRSYSCELCDSPEARWPRKYLLHQHHQKEHTW 513
            .|.:|                     |:      :.|.|..||...|  ...||  :.||:.|:.
  Rat   515 QRTHS---------------------GE------KPYKCNECDKAFA--GSSYL--RSHQRIHSG 548

  Fly   514 LDAPHVCQRCDSRFLNLQLLKHHTSQLCQNTLKRFMCDKCPQRFFWRRNLRAHLVEHKCKQESYP 578
             ..|:.|..||..|.....|:.|  |......|.:.|.:|.:.|..:.::|.|...| ..::.|.
  Rat   549 -KKPYKCSECDKSFNRKDHLRIH--QRVHTGEKPYKCSECDKCFTQKGSVRIHQRIH-TGEKPYK 609

  Fly   579 CDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALLYKHLQRHGFTGQDLPLAETL 643
            |.:|.:||..|..:..|:::   .:..|...|..|.::|.|...|..|.:.|
  Rat   610 CSKCDKSFTKKDGLVIHQII---HTGEEPYKCSECDKSFNRKDHLRTHQRFH------------- 658

  Fly   644 LADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAYMISTATGFELLLDDTDDSDEE 708
                   .|.:..:|..||..|...:.||.|..:                              .
  Rat   659 -------TGERIYKCSECDEYFTQKSSLRIHQKI------------------------------H 686

  Fly   709 TSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHCIFKTVDKNMLHQHLRTQCMNTEKK 773
            |..:||.|.:|..:|.||..:..|: .:|:.:| |::|............|..|.|   :::.||
  Rat   687 TGDKTYKCSVCGKSFNRRNHLRTHE-RIHAGEK-PYDCTEFENSFTHNGSLRIHHR---LHSRKK 746

  Fly   774 -FACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRRFRYQCPHCWRSFVVQPSLDKHI 837
             :.|..|...|.....:..|......::|                |:|..|.:.|.....|..|.
  Rat   747 VYKCSECDKSFTSSSYVRIHQRIHSGEKP----------------YKCSECNKCFTSGSYLRMHQ 795

  Fly   838 RDMHVAKKNPGKKYLCSLCGLESLTPNKLNIHMRRHTGEKPFKCDLCDMRFTVHYELKVHRRKHT 902
            | :|...| |.|...|..|..:..:   |.||.|.||||||:||..|:..||....|::|:|.|.
  Rat   796 R-IHTGDK-PYKCGECDKCFTQKCS---LRIHQRSHTGEKPYKCGNCERSFTSGSYLRIHQRIHK 855

  Fly   903 GERPYQCTFCDKDFARPDKLRRHVFMH 929
            ||:||:|:.|||.|.:...||.|..:|
  Rat   856 GEKPYKCSECDKSFTQKGYLRIHQRIH 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_651388.1	zf-AD	4..80	CDD:462262	23/110 (21%)
		C2H2 Zn finger	178..199	CDD:275368	8/20 (40%)
		C2H2 Zn finger	216..233	CDD:275368	4/16 (25%)
		C2H2 Zn finger	520..542	CDD:275368	7/21 (33%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
		C2H2 Zn finger	579..600	CDD:275368	6/20 (30%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..737	CDD:275368	6/20 (30%)
		C2H2 Zn finger	746..766	CDD:275368	4/19 (21%)
		C2H2 Zn finger	776..795	CDD:275368	4/18 (22%)
		C2H2 Zn finger	820..838	CDD:275368	5/17 (29%)
		C2H2 Zn finger	853..873	CDD:275368	6/19 (32%)
		zf-H2C2_2	866..889	CDD:463886	13/22 (59%)
		C2H2 Zn finger	881..901	CDD:275368	7/19 (37%)
		zf-H2C2_2	893..918	CDD:463886	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	8/19 (42%)
Zfp945	XP_006228161.2	KRAB	131..171	CDD:460171	6/40 (15%)
		C2H2 Zn finger	302..322	CDD:275368	8/20 (40%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	358..378	CDD:275368	1/19 (5%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	3/19 (16%)
		zf-H2C2_2	455..479	CDD:463886	8/32 (25%)
		C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
		C2H2 Zn finger	498..518	CDD:275368	1/19 (5%)
		COG5048	522..872	CDD:227381	112/436 (26%)
		C2H2 Zn finger	526..546	CDD:275368	8/23 (35%)
		C2H2 Zn finger	554..574	CDD:275368	7/21 (33%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
		C2H2 Zn finger	610..630	CDD:275368	6/22 (27%)
		C2H2 Zn finger	638..658	CDD:275368	6/19 (32%)
		C2H2 Zn finger	666..686	CDD:275368	7/49 (14%)
		C2H2 Zn finger	694..714	CDD:275368	6/20 (30%)
		C2H2 Zn finger	722..742	CDD:275368	4/22 (18%)
		C2H2 Zn finger	750..770	CDD:275368	4/19 (21%)
		C2H2 Zn finger	778..798	CDD:275368	6/20 (30%)
		C2H2 Zn finger	806..826	CDD:275368	6/22 (27%)
		C2H2 Zn finger	834..854	CDD:275368	7/19 (37%)
		C2H2 Zn finger	862..882	CDD:275368	8/19 (42%)