DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10669 and 9130023H24Rik

DIOPT Version :9

Sequence 1:	NP_001163728.1	Gene:	CG10669 / 43069	FlyBaseID:	FBgn0039329	Length:	933	Species:	Drosophila melanogaster
Sequence 2:	NP_795975.1	Gene:	9130023H24Rik / 100043133	MGIID:	2442738	Length:	337	Species:	Mus musculus

Alignment Length:	376	Identity:	111/376 - (29%)
Similarity:	159/376 - (42%)	Gaps:	83/376 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   560 RRNL-RAHLVEHKCKQESYPCDQCSRSFQDKSAVTKHKLMMHRDSNMELLPCRWCTRTFYRPALL 623
            |.|| .|.|:|::..:  :|  ...||..|:......:.::.|..               :||.:
Mouse    10 RENLDGAKLLENRTSK--FP--GAPRSPLDRETALHERPLLARPE---------------QPAPV 55

  Fly   624 YKHL-QRHGFTGQDLPLAETLLADASKPAGPKSVQCKICDIQFVSVADLRRHISMQGHSDQPSAY 687
            .|.| |::.......|..||.: ..|.||.||:.:|:.|.:...|::||..|.|..| .|:|
Mouse    56 EKMLDQQYLCRSGSGPKEETFV-KTSDPAVPKAFKCRDCGLAVPSLSDLIHHQSSHG-CDRP--- 115

  Fly   688 MISTATGFELLLDDTDDSDEETSGRTYSCDLCDLNFRRRREISEHQYSLHSFDKLPHNCEHC--I 750
                                      |||..||.:|||..::.:| |.:||.:| |:.|..|  .
Mouse   116 --------------------------YSCPECDKSFRRGSDLVKH-YRVHSGEK-PYPCPECGRC 152

  Fly   751 FKTVDKNMLHQHLRTQCMNTEKKFACMRCGYKFMWEENLAQHLSTQHSKQPAVPEQQPPLRRKRR 815
            | ::..| |.:|.|:.  :..:...||.||..|....:||:|......::|
Mouse   153 F-SLSSN-LTKHRRSH--SGLRPHKCMECGEAFGRSADLAKHQRVHTGEKP-------------- 199

  Fly   816 FRYQCPHCWRSFVVQPSLDKHIRDMHVAKKNPGKKYLCSLCGLE-SLTPNKLNIHMRRHTGEKPF 879
              |.|..|.::|.|..:|.:|.| .|..:    |.|.|.|||.. ||:.|.|. |.|.||||||:
Mouse   200 --YACAECGKTFRVSSNLIQHQR-THTGE----KPYRCGLCGKSFSLSSNLLQ-HQRCHTGEKPY 256

  Fly   880 KCDLCDMRFTVHYELKVHRRKHTGERPYQCTFCDKDFARPDKLRRHVFMHN 930
            .|..|...|.....|..|:|.||||:||.|..|.|:|.......||...||
Mouse   257 FCAWCGDSFGRSSYLLEHQRSHTGEKPYNCCECGKNFTNSSNCLRHQRTHN 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10669	NP_001163728.1	zf-AD	4..81	CDD:285071
		C2H2 Zn finger	178..199	CDD:275368
		C2H2 Zn finger	216..233	CDD:275368
		C2H2 Zn finger	520..542	CDD:275368
		C2H2 Zn finger	550..570	CDD:275368	5/10 (50%)
		C2H2 Zn finger	579..600	CDD:275368	3/20 (15%)
		C2H2 Zn finger	610..630	CDD:275368	5/20 (25%)
		C2H2 Zn finger	716..737	CDD:275368	8/20 (40%)
		C2H2 Zn finger	746..766	CDD:275368	7/21 (33%)
		C2H2 Zn finger	776..795	CDD:275368	8/18 (44%)
		C2H2 Zn finger	820..838	CDD:275368	6/17 (35%)
		C2H2 Zn finger	853..873	CDD:275368	10/20 (50%)
		zf-H2C2_2	866..889	CDD:290200	11/22 (50%)
		COG5048	877..>930	CDD:227381	20/52 (38%)
		C2H2 Zn finger	881..901	CDD:275368	6/19 (32%)
		zf-H2C2_2	893..918	CDD:290200	13/24 (54%)
		C2H2 Zn finger	909..929	CDD:275368	6/19 (32%)
9130023H24Rik	NP_795975.1	C2H2 Zn finger	90..110	CDD:275368	7/19 (37%)
		COG5048	<111..270	CDD:227381	63/216 (29%)
		zf-C2H2	116..138	CDD:278523	10/22 (45%)
		C2H2 Zn finger	118..138	CDD:275368	8/20 (40%)
		zf-H2C2_2	130..154	CDD:290200	9/26 (35%)
		zf-C2H2	144..166	CDD:278523	7/23 (30%)
		C2H2 Zn finger	146..166	CDD:275368	7/21 (33%)
		zf-H2C2_2	158..183	CDD:290200	9/27 (33%)
		C2H2 Zn finger	174..194	CDD:275368	8/19 (42%)
		zf-H2C2_2	186..209	CDD:290200	7/38 (18%)
		C2H2 Zn finger	202..222	CDD:275368	7/20 (35%)
		zf-H2C2_2	214..238	CDD:290200	10/28 (36%)
		C2H2 Zn finger	230..250	CDD:275368	10/20 (50%)
		COG5048	254..>314	CDD:227381	22/54 (41%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		zf-H2C2_2	270..295	CDD:290200	13/24 (54%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930