Protein Alignment RIOK2 and Riok2

DIOPT Version :9

• Sequence 1: NP_651365.1
• Gene: RIOK2 / 43046
• FlyBaseID: FBgn0039306
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_080210.1
• Gene: Riok2 / 67045
• MGIID: 1914295
• Length: 547
• Species: Mus musculus
• Alignment Length: 571
• Identity: 261/571 - (45%)
• Similarity: 349/571 - (61%)
• Gaps: 75/571 - (13%)

  Fly     1 MGKLNVTVLRYLTKEDFRVLTAIEMGMKNHELVPGPLAAAIANLKSGGVHKLLKELCKHKLLAYE 65
            |||:||..|||::::|||||||:||||||||:||..|.|:||:||.||.:|:|:||.||||:|:|
Mouse     1 MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPCSLIASIASLKHGGCNKILRELVKHKLIAWE 65

  Fly    66 RGKKYDGYRLTNTGYDYLALKSLTLRGSVSSFGNQIGIGKESNIYVVADEEGTPICLKLHRLGRT 130
            |.|...||||||.||||||||:|:.|..|.|.|||:|:||||:||:||:|.|..:.|||||||||
Mouse    66 RTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEAGQQLALKLHRLGRT 130

  Fly   131 CFRNVKAKRDYHGRRHKASWLYLSRISATREFAYMSALYDRGFPVPKPIDFNRHCVLMDLVKGWP 195
            .|||:|.|||||..||..|||||||:||.:|||||.|||:|.||||||||:|||.|:|:|:.|:|
Mouse   131 SFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVIMELINGYP 195

  Fly   196 MTQVHELLDAPQVYDDLMNLIVRLGNSGVIHGDFNEFNLMVTDAGKPILIDFPQMMSTSHENAEF 260
            :.|:|.:.|...|||:.|.|||:|||.|:|||||||||||:.......:||||||:||||.|||:
Mouse   196 LCQIHHVEDPASVYDEAMELIVKLGNHGLIHGDFNEFNLMLDKDDHITMIDFPQMVSTSHPNAEW 260

  Fly   261 FFERDVNCVREMFRRKFGYESEDYPKFSDLVREDDLDAEVHCTGYGFTKEMEQD--LLEEYGMVD 323
            :|:|||.|:||.|.::|.||||.||.|||:.:||.||.||..:||  ||||:.|  ||...|..|
Mouse   261 YFDRDVKCIREFFMKRFSYESELYPTFSDIRKEDSLDVEVSASGY--TKEMQADDELLHPVGPDD 323

  Fly   324 QADEEDEGEDLEEEEEPPTLVTAASVEIDECRRQVENEVIYSEAKPTQKSDDAVRRYIESCTQYL 388
            :..|.:|..|....:|  .::..|.|    .|.::|     .||.|..:|.
Mouse   324 KITETEEDSDFTFSDE--EMLEKAKV----WRSELE-----KEADPADESG-------------- 363

  Fly   389 GNLSVGPEVPDQTMPKKL-DISLPAETPDVIPFEAETSATNTVEEDVKSI--------------- 437
                 |......|..|:: |..||.|:..|..||. |:.:..|||..:.:
Mouse   364 -----GSWCCSSTDSKQIKDGGLPEESAHVSSFEV-TALSQAVEEMERQVLPHRSVTEFSEESRR 422

  Fly   438 -------------SSNDLDTDEVPELVGLDPNSRMYR-LKMVEQMLNDARSQ-RSYSTTT----- 482
                         .|.|.| ||.|.|:.|...:|.:| .:..|.|.:..|.: |:.|.|:
Mouse   423 TENDGQPGQRSPAGSEDCD-DEPPHLIALSSVNREFRPFRDEESMSSVTRHRTRTLSVTSAGSAL 486

  Fly   483 --STIAPSVITDRIRRNMDIKEKREQRKKCVAKGEASAVHRHRKENKDVVK 531
              |||.|.::..:::|.:..::|...|:: :.||||:...:.|:||...:|
Mouse   487 SCSTIPPELVKQKVKRQLTRQQKAAARRR-LQKGEANVFTKQRRENMQNIK 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIOK2	NP_651365.1	RIO2	3..282	CDD:223554	178/278 (64%)
		Rio2_N	9..91	CDD:286310	55/81 (68%)
		RIO2_C	94..276	CDD:270695	116/181 (64%)
Riok2	NP_080210.1	RIO2	8..308	CDD:223554	191/301 (63%)
		Rio2_N	9..91	CDD:286310	55/81 (68%)
		RIO2_C	94..276	CDD:270695	116/181 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..385		11/56 (20%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9BVS4	399..408		3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..445		5/41 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831403
Domainoid	1	1.000	242	1.000	Domainoid score	I2222
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6760
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1599
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005212
OrthoInspector	1	1.000	-	-		oto92603
orthoMCL	1	0.900	-	-		OOG6_101547
Panther	1	1.100	-	-	LDO	PTHR45852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1103
SonicParanoid	1	1.000	-	-		X3725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.880