Protein Alignment RIOK2 and RIOK2

DIOPT Version :9

• Sequence 1: NP_651365.1
• Gene: RIOK2 / 43046
• FlyBaseID: FBgn0039306
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_060813.2
• Gene: RIOK2 / 55781
• HGNCID: 18999
• Length: 552
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 254/560 - (45%)
• Similarity: 350/560 - (62%)
• Gaps: 48/560 - (8%)

  Fly     1 MGKLNVTVLRYLTKEDFRVLTAIEMGMKNHELVPGPLAAAIANLKSGGVHKLLKELCKHKLLAYE 65
            |||:||..|||::::|||||||:||||||||:|||.|.|:||:||.||.:|:|:||.||||:|:|
Human     1 MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWE 65

  Fly    66 RGKKYDGYRLTNTGYDYLALKSLTLRGSVSSFGNQIGIGKESNIYVVADEEGTPICLKLHRLGRT 130
            |.|...||||||.||||||||:|:.|..|.|.|||:|:||||:||:||:|||....|||||||||
Human    66 RTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRT 130

  Fly   131 CFRNVKAKRDYHGRRHKASWLYLSRISATREFAYMSALYDRGFPVPKPIDFNRHCVLMDLVKGWP 195
            .|||:|.|||||..||..|||||||:||.:|||||.|||:|.||||||||:|||.|:|:|:.|:|
Human   131 SFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYP 195

  Fly   196 MTQVHELLDAPQVYDDLMNLIVRLGNSGVIHGDFNEFNLMVTDAGKPILIDFPQMMSTSHENAEF 260
            :.|:|.:.|...|||:.|.|||:|.|.|:||||||||||::.::....:||||||:||||.|||:
Human   196 LCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEW 260

  Fly   261 FFERDVNCVREMFRRKFGYESEDYPKFSDLVREDDLDAEVHCTGYGFTKEMEQD--LLEEYGMVD 323
            :|:|||.|:::.|.::|.||||.:|.|.|:.|||.||.||..:||  ||||:.|  ||...|..|
Human   261 YFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGY--TKEMQADDELLHPLGPDD 323

  Fly   324 QADEEDEGEDLE----EEEEPPTLVTAASVEIDECRRQVENEVIYSEAKPTQKSDDAVRRYIESC 384
            :..|..||.:..    |..|...:..:.:.....|..:.|.....|...|.|..:|::..  ||.
Human   324 KNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSE--ESA 386

  Fly   385 -------TQYLGNLSVGPEVPDQTMPKKLDISLPAETPDVIPFEAETSAT-NTVEEDVKSI---- 437
                   |::...|.   |:..|.:          |...|..|..|.:.| |...:|.:.:
Human   387 DARSFEMTEFNQALE---EIKGQVV----------ENNSVTEFSEEKNRTENYNRQDGQRVQGGV 438

  Fly   438 -SSNDLDTDEVPELVGLDPNSRMYRLKMVEQ---MLNDARSQRSYSTTT-------STIAPSVIT 491
             :.:|...||.|.|:.|...:|.:|....|:   .:|..|: |:.|.|:       |||.|.::.
Human   439 PAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRT-RTLSITSSGSAVSCSTIPPELVK 502

  Fly   492 DRIRRNMDIKEKREQRKKCVAKGEASAVHRHRKENKDVVK 531
            .:::|.:..::|...|:: :.||||:...:.|:||...:|
Human   503 QKVKRQLTKQQKSAVRRR-LQKGEANIFTKQRRENMQNIK 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIOK2	NP_651365.1	RIO2	3..282	CDD:223554	176/278 (63%)
		Rio2_N	9..91	CDD:286310	56/81 (69%)
		RIO2_C	94..276	CDD:270695	113/181 (62%)
RIOK2	NP_060813.2	Rio2_N	9..91	CDD:401225	56/81 (69%)
		RIO2_C	94..276	CDD:270695	113/181 (62%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:19564402	399..408		1/8 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141451
Domainoid	1	1.000	239	1.000	Domainoid score	I2293
eggNOG	1	0.900	-	-		E1_COG0478
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6760
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1623
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010730at2759
OrthoFinder	1	1.000	-	-		FOG0005212
OrthoInspector	1	1.000	-	-		oto89036
orthoMCL	1	0.900	-	-		OOG6_101547
Panther	1	1.100	-	-	LDO	PTHR45852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1103
SonicParanoid	1	1.000	-	-		X3725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790