DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RIOK2 and riok-2

DIOPT Version :9

Sequence 1:	NP_651365.1	Gene:	RIOK2 / 43046	FlyBaseID:	FBgn0039306	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_493544.2	Gene:	riok-2 / 173322	WormBaseID:	WBGene00013688	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	237/557 - (42%)
Similarity:	332/557 - (59%)	Gaps:	50/557 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKLNVTVLRYLTKEDFRVLTAIEMGMKNHELVPGPLAAAIANLKSGGVHKLLKELCKHKLLAYE 65
            ||::||:::|||..:.||||.|:||||||||:||..|.:|||.:..|||.:.|.:||||.|:|:|
Worm     1 MGRMNVSMMRYLEGDHFRVLIAVEMGMKNHEVVPLALVSAIAGIHRGGVARTLNDLCKHSLVAFE 65

  Fly    66 RGKKYDGYRLTNTGYDYLALKSLTLRGSVSSFGNQIGIGKESNIYVVADEEGTPICLKLHRLGRT 130
            |.||:||||||..|||||||::|..|..|.|.||||||||||::||..|.|...:|||.||||||
Worm    66 RSKKFDGYRLTIRGYDYLALRALCSREVVGSVGNQIGIGKESDVYVGGDPELNDLCLKFHRLGRT 130

  Fly   131 CFRNVKAKRDYHGRRHKASWLYLSRISATREFAYMSALYDRGFPVPKPIDFNRHCVLMDLVKGWP 195
            .||.:|.|||||.:|..||||||||::|.:|||::.||.:|||||||.:|..||.|:|.||.|..
Worm   131 SFRKIKEKRDYHKKRKSASWLYLSRLAAAKEFAFLKALQERGFPVPKAVDVCRHLVVMQLVVGQT 195

  Fly   196 MTQVHELLDAPQVYDDLMNLIVRLGNSGVIHGDFNEFNLMVTDAGKPILIDFPQMMSTSHENAEF 260
            :..|..:.||..:||.||.|||::...||||||||||||::.:..:.::||||||:|..|.|||:
Worm   196 LCNVTHVEDAGALYDRLMALIVKMARHGVIHGDFNEFNLIMLEDERIVMIDFPQMVSIDHPNAEY 260

  Fly   261 FFERDVNCVREMFRRKFGYESEDYPKFSDLVREDDLDAEVHCTGYGFTKEMEQDLLEEYGMVDQA 325
            :|:|||.|||..|:|||.|||||:|||.::.|:.::|..:..:  ||||:|..||.:.|   |:.
Worm   261 YFDRDVTCVRTFFKRKFDYESEDWPKFDEVERKGNMDVLLEAS--GFTKKMALDLNKAY---DEG 320

  Fly   326 D-------------EEDEGEDLEEEEEPPTLVTAASVEIDECRRQVENEVIYSEAKP-TQKSDDA 376
            |             |||.|||.::.::..::     .:|.|....:|.:....:|:. |.|....
Worm   321 DFLAHCEQELRNRQEEDLGEDEDDSDDSKSM-----EDIQEEPEDLEKDHEELQAQENTVKQQKI 380

  Fly   377 VRRYIESCTQYLGNLSVGPEVPDQTMPKK----LDISLPAETPDVIPFEAETSATNTVEEDVKSI 437
            |.......|.:|.:.:...|..|....|.    .||.||.|     .|:....:.|..|.|....
Worm   381 VLSQTTRFTDWLSDATNQLEAVDLDALKSEEGYKDIELPPE-----DFKRPADSENDDENDEDEE 440

  Fly   438 SSNDLDTDEVPELVGLDPNSRMYRLKMVEQMLNDARSQR--SYSTTTSTIAPSVITDRIRRNMDI 500
            ...:.|.|.              .:.:.||:....:.:|  |.:.:.::.|.:...:.::|.:.:
Worm   441 EGEEEDADG--------------HVAVEEQVAKVVKKKRVPSGARSVASSAATFTAEDVKRRLAL 491

  Fly   501 KEKREQRK-KCVAKGEASAVHRHRKENKDVVKEYAGW 536
            ..||.:.| :...||:.|||.|:||:||||:.|||||
Worm   492 DRKRNKEKIRLKVKGKQSAVGRNRKDNKDVIAEYAGW 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RIOK2	NP_651365.1	RIO2	3..282	CDD:223554	162/278 (58%)
		Rio2_N	9..91	CDD:286310	50/81 (62%)
		RIO2_C	94..276	CDD:270695	104/181 (57%)
riok-2	NP_493544.2	RIO2	6..314	CDD:223554	175/309 (57%)
		Rio2_N	9..91	CDD:286310	50/81 (62%)
		RIO2_C	94..276	CDD:270695	104/181 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156497
Domainoid	1	1.000	207	1.000	Domainoid score	I1683
eggNOG	1	0.900	-	-		E1_COG0478
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6760
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1033
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53873
OrthoDB	1	1.010	-	-		D1010730at2759
OrthoFinder	1	1.000	-	-		FOG0005212
OrthoInspector	1	1.000	-	-		oto20455
orthoMCL	1	0.900	-	-		OOG6_101547
Panther	1	1.100	-	-	LDO	PTHR45852
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1103
SonicParanoid	1	1.000	-	-		X3725
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840