DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10425 and TSC10

DIOPT Version :9

Sequence 1:	NP_651363.1	Gene:	CG10425 / 43043	FlyBaseID:	FBgn0039304	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_009824.2	Gene:	TSC10 / 852568	SGDID:	S000000469	Length:	320	Species:	Saccharomyces cerevisiae

Alignment Length:	324	Identity:	78/324 - (24%)
Similarity:	138/324 - (42%)	Gaps:	49/324 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VVVTGGSKGIGLCLAVECAMKGAN--VTVIARDEKML---SGAVALMEVIRQRP----------- 86
            |::||||:|:|...|.:...:..|  :.:::|.|..|   ...:.:...:|:..
Yeast    10 VLITGGSQGLGKEFAKKYYNEAENTKIIIVSRSEARLLDTCNEIRIEAHLRRETTDEGQVQHKLA 74

  Fly    87 -----DQKFQYRSLDISGDYDQVAKVLGEIED-SFGPIYTLINCAGMAICGVFEEVSVQDVHKLM 145
                 :|:..|...|:| .|:.|..:...:.| ...|..||. |||.|:..:|..:|..:::..|
Yeast    75 APLDLEQRLFYYPCDLS-CYESVECLFNALRDLDLLPTQTLC-CAGGAVPKLFRGLSGHELNLGM 137

  Fly   146 NVNFFGTYNCTRYV-LPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAMESRE 209
            ::|:..|.|....: |.:..|  :..::|.:|..|::...||..|:..|.|::::...:..|...
Yeast   138 DINYKTTLNVAHQIALAEQTK--EHHLIIFSSATALYPFVGYSQYAPAKAAIKSLVAILRQELTN 200

  Fly   210 HGVSVTLAMPCDTNTPGFEEEEKSKPRETKIISGGGGLIEPEVMAKAILKDALKGK---FTSTVG 271
            ..:|  ...|.:..:.||..|:.:||..||:|.|....|..:.....|.|...:|.   ||..||
Yeast   201 FRIS--CVYPGNFESEGFTVEQLTKPEITKLIEGPSDAIPCKQACDIIAKSLARGDDDVFTDFVG 263

  Fly   272 AESWLI-------TTLGGALLPWDGFFTNLLHAIVLGPLRIVSYALHKYFNSVIRKCAREDKAK 328
               |:|       |......:|....| .:|..|::.|..:|..:.:      |||..||:..|
Yeast   264 ---WMIMGMDLGLTAKKSRFVPLQWIF-GVLSNILVVPFYMVGCSWY------IRKWFRENDGK 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10425	NP_651363.1	KDSR-like_SDR_c	35..271	CDD:187643	61/258 (24%)
CG10425	NP_651363.1	adh_short	36..229	CDD:278532	48/213 (23%)
TSC10	NP_009824.2	KDSR-like_SDR_c	7..263	CDD:187643	61/258 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344837
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S2981
OMA	1	1.010	-	-		QHG53570
OrthoFinder	1	1.000	-	-		FOG0004308
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102003
Panther	1	1.100	-	-	LDO	PTHR43550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1750
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.730