DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10425 and Kdsr

DIOPT Version :9

Sequence 1:	NP_651363.1	Gene:	CG10425 / 43043	FlyBaseID:	FBgn0039304	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	XP_038946804.1	Gene:	Kdsr / 360833	RGDID:	1307775	Length:	367	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	118/352 - (33%)
Similarity:	196/352 - (55%)	Gaps:	38/352 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IVFCVGIAVLVHVLVYVF--VMAKKPRSIVGRHVVVTGGSKGIGLCLAVECAMKGANVTVIARDE 69
            ::...|:...| :|:|:.  :::.||.::.|.||||||||.|||.|:|:||..:||.:|::||:|
  Rat     3 LLAAAGLVAFV-LLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNE 66

  Fly    70 KMLSGAVALMEVIRQRPDQKFQYRSLDISGDYDQVAKVLGEIEDSFGPIYTLINCAGMAICGVFE 134
            ..|..|...:|.......|.....|:|:|.||:||..|:.:.::..||:..|:||||.:..|.||
  Rat    67 DKLLQAKKEIEKYSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGTSKSGKFE 131

  Fly   135 EVSVQDVHKLMNVNFFGTYNCTRYVLPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAM 199
            |:.|....|||::|:.|:...:|.|:..||:...|.||..:|||...|::|:..||::|:|:|.:
  Rat   132 ELEVSSFEKLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGL 196

  Fly   200 AETIAMESREHGVSVTLAMPCDTNTPGFEEEEKSKPRETKIISGGGGLIEPEVMAKAILKDAL-- 262
            ||.:.||.:.:.|.||:|.|.||:|||..||.|:||.||::||....:.:||.:||.|:|||:
  Rat   197 AEALQMEVKPYNVYVTVAYPPDTDTPGLAEENKTKPLETRLISETTAVCKPEQVAKQIVKDAIES 261

  Fly   263 ---------------------------------KGKFTSTVGAESWLITTLGGALLPWDGFFTNL 294
                                             :|.|.|::|::.:::::|...:.|.......|
  Rat   262 RGLNSHQAWCLGLRTEPGLRPCFIPSHGLRPSKQGNFNSSIGSDGYMLSSLTCGMAPVTSITEGL 326

  Fly   295 LHAIVLGPLRIVSYALHKYFNSVIRKC 321
            ...:.:|..|.::......|:::||:|
  Rat   327 QQVVTMGLFRTIALFYLGSFDNIIRRC 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10425	NP_651363.1	KDSR-like_SDR_c	35..271	CDD:187643	102/270 (38%)
CG10425	NP_651363.1	adh_short	36..229	CDD:278532	81/192 (42%)
Kdsr	XP_038946804.1	KDSR-like_SDR_c	32..258	CDD:187643	97/225 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346106
Domainoid	1	1.000	166	1.000	Domainoid score	I3810
eggNOG	1	0.900	-	-		E1_KOG1210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1539
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3373
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D1210617at2759
OrthoFinder	1	1.000	-	-		FOG0004308
OrthoInspector	1	1.000	-	-		oto97880
orthoMCL	1	0.900	-	-		OOG6_102003
Panther	1	1.100	-	-	LDO	PTHR43550
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1429
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770