DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup358 and GCC2

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	XP_006712933.1	Gene:	GCC2 / 9648	HGNCID:	23218	Length:	1687	Species:	Homo sapiens

Alignment Length:	1061	Identity:	204/1061 - (19%)
Similarity:	382/1061 - (36%)	Gaps:	328/1061 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTTRKE---VDAHVHKMLGKLQ-PGRERD-----IKGLAVARLYMKVQEYPKAIEYLNGYLR-- 54
            :|.::||   :..|:.::..||| ...|:|     ::...|.:|::|.|.|        |:|:
Human   713 VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLY--------GFLKEM 769

  Fly    55 ---VRDD-----------AVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELL 105
               |.:|           |||.::     :::|......|.|..::.:::   :.|:     :.|
Human   770 GSEVSEDSEEKDVVNVLQAVGESL-----AKINEEKCNLAFQRDEKVLEL---EKEI-----KCL 821

  Fly   106 VKENNASITECARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYK 170
            .:|   |:.:|     ::..||          ||                  |.||.  ::|:.|
Human   822 QEE---SVVQC-----EELKSL----------LR------------------DYEQE--KVLLRK 848

  Fly   171 ELQARPQDVNIRIQLLRSYVEKMKIDQAFNYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKD 235
            ||    :::....:.|:|.:.:||     |...||.||::|...|    .|::.....|.|:..:
Human   849 EL----EEIQSEKEALQSDLLEMK-----NANEKTRLENQNLLIQ----VEEVSQTCSKSEIHNE 900

  Fly   236 VKKNWRFWHFALHTLDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACI 300
            .:|.:...|..|..|       ||...|.|...:|..|...|.| |.|::....:..::|.:. |
Human   901 KEKCFIKEHENLKPL-------LEQKELRDRRAELILLKDSLAK-SPSVKNDPLSSVKELEEK-I 956

  Fly   301 DHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSS------TNQWIKHC 359
            ::...:..        ::|...||.|            |:..:.:...|||      ..:.::..
Human   957 ENLEKECK--------EKEEKINKIK------------LVAVKAKKELDSSRKETQTVKEELESL 1001

  Fly   360 DAEQKQLIQMWRP--QGAFRCAQLGRTLLGCLDRS-QMEIKNDRENAEFDEN--------KNSGN 413
            .:|:.||....|.  |||.....|   ||....:| |::::.:|.| .|:..        :||..
Human  1002 RSEKDQLSASMRDLIQGAESYKNL---LLEYEKQSEQLDVEKERAN-NFEHRIEDLTRQLRNSTL 1062

  Fly   414 SMPGLFADSEELLASAH-------------------QQCLDKSWRSQIYQQLFTHAEHKLKD--T 457
            ....:.:|:|:|||...                   :..:||...::..|:     |.|:|:  |
Human  1063 QCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK-----EQKIKEHAT 1122

  Fly   458 SSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLALGTDPNKLGDAPRVVFYEGF 522
            :.:.:..|::||.    .....::. .:|.|.|......|...:.:           .:..||..
Human  1123 TVNELEELQVQLQ----KQKKQLQK-TMQELELVKKDAQQTTLMNM-----------EIADYERL 1171

  Fly   523 QRDVKQNLNYCGQDSISQVDVDLYLYATTIQTRRKLQIQREV---------YDSSN--------- 569
            .:::.|.|.. ..:.|..::.::     .||.:::..:|.|:         |:..|
Human  1172 MKELNQKLTN-KNNKIEDLEQEI-----KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVK 1230

  Fly   570 ----LGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNR--------AEQRA 622
                |.:...|...|::..|:|.|:|.|.:|.   ..|.::...::.:|.::        |||..
Human  1231 TKKELADSKQAETDHLILQASLKGELEASQQQ---VEVYKIQLAEITSEKHKIHEHLKTSAEQHQ 1292

  Fly   623 Q-----------LQHGLEAVRGVNGPKADAIIIFQLGKIL-------------------NSRSDR 657
            :           ||   |..|.....:|.....|:..|:.                   .::.:|
Human  1293 RTLSAYQQRVTALQ---EECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQER 1354

  Fly   658 SSLEARIDTL--------------------YRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQ 702
            ..||..||.|                    .:.....|..:||:.::..|         |..|
Human  1355 EHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETV---------SKEA-- 1408

  Fly   703 DLQSLAEEAVTYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSE 767
               .|.|:..:..||.|....::.|.:.::...:..:....:.:..|..||..|...|.:.:.|:
Human  1409 ---ELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSK 1470

  Fly   768 RRRECLQKTQKLIKNDDKHPLIAAMHRHQQD----RNSRGIDNSFGSP--DVH----NNSSAYED 822
            ...:..|     :||:   |...:....||.    |..|..|    .|  |:|    ......|.
Human  1471 MEAQLFQ-----LKNE---PTTRSPVSSQQSLKNLRERRNTD----LPLLDMHTVTREEGEGMET 1523

  Fly   823 AEDDFYSHAAFSANRSRRQLEVTPVT----PIVMAQ-PSQEMEQAVKQISKSL----CVLKDDVS 878
            .:.:..|.|: :..:|..||..:|.|    |:..|: ..:|:.|.:...:||.    .:|::..:
Human  1524 TDTESVSSAS-TYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEA 1587

  Fly   879 VGMEAMRQDIKVLTEKFTGLE 899
            .....|.| ||:|..:...||
Human  1588 TNAILMEQ-IKLLKSEIRRLE 1607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533	26/135 (19%)
		TPR repeat	58..90	CDD:276809	7/42 (17%)
		Atrophin-1	<1030..1308	CDD:331285
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
GCC2	XP_006712933.1	Smc	44..956	CDD:224117	69/323 (21%)
		SMC_prok_B	703..1481	CDD:274008	172/924 (19%)
		Rab_bind	1551..1615	CDD:293309	14/58 (24%)
		GRIP	1617..1659	CDD:279767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40852
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900