DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nup358 and RGPD5

DIOPT Version :9

Sequence 1:NP_001247302.1 Gene:Nup358 / 43041 FlyBaseID:FBgn0039302 Length:2718 Species:Drosophila melanogaster
Sequence 2:XP_006712857.2 Gene:RGPD5 / 84220 HGNCID:32418 Length:1791 Species:Homo sapiens


Alignment Length:2352 Identity:509/2352 - (21%)
Similarity:840/2352 - (35%) Gaps:762/2352 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 EVDAHVHKMLGKLQPG-------RERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRD-DAVGHN 63
            :.|...|..| :|.|.       ..:.:||...|:||.:.:||..|.:|:..|:.|:: |...|.
Human    27 DADTSHHGQL-RLSPAPGMGPRVTVKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHR 90

  Fly    64 MIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITE-CARYWLDQANSL 127
            .:...|..  ..:..:|::.|:||::::|.|.::|:...|||.|.:   :|: .|:||:::|..|
Human    91 FLGLLYEL--EENTEKAVECYRRSVELNPTQKDLVLKIAELLCKND---VTDGRAKYWVERAAKL 150

  Fly   128 DLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEK 192
             ..|:..::.|:.:  |.|..||       || .|.|..|:..||..||.||::.|:|:..|...
Human   151 -FPGSPAIYKLKEQ--LLDCEGE-------DG-WNKLFDLIQSELYVRPDDVHVNIRLVELYRST 204

  Fly   193 MKIDQAF--------NYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHT 249
            .::..|.        |.||::.||..:|..|:.:.|      |..::..:..|.:|:    |.:|
Human   205 KRLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEY------LESLQCLESDKSDWQ----ATNT 259

  Fly   250 -----LDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLL 309
                 ...|:.|:|....:.::.:.|...|..|....:|:  .|:    |...|......|...:
Human   260 DLLLAYANLMLLTLSTRDVQENRELLESFDSALQSAKSSL--GGN----DELSATFLEMKGHFYM 318

  Fly   310 HAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQG 374
            :|.:|:.|.....|..:|.:....|....|:.:||.                         ||:.
Human   319 YAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVP-------------------------RPKI 358

  Fly   375 AFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWR 439
            ..|..:.|:.||              |....|....||:.:..|....::.|....:...:|..:
Human   359 KLREGKAGQNLL--------------EMMACDRLSQSGHMLLSLSRGKQDFLKEVVETFANKIGQ 409

  Fly   440 SQIYQQLFTHAEHKLKDTS---SHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYL 501
            |.:|..||  :....||||   |..:..:.:|     .|.|..:..|::.|:.....|| ||: .
Human   410 SALYDALF--SSQSPKDTSFLGSDDIGKIDVQ-----EPELEDLARYDVGAIRAHNGSL-QHL-T 465

  Fly   502 ALGTDPNKLGDAPRVVFYEGFQRDVKQ----------NLNYCGQDSISQVDVDLYL----YATTI 552
            .||...|.|...|      |.::.:||          .|.....:||..:|::::|    |.:.:
Human   466 WLGLQWNSLPALP------GIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHL 524

  Fly   553 QTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNR 617
            |.:.|.......|            :|..:||. :..||....|.:|||.|..|...:.: .||.
Human   525 QLKEKCNSHHSSY------------QPLCLPFP-VCKQLCTERQKSWWDAVCTLIHRKAV-PGNL 575

  Fly   618 AE-----------QRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNS---------RS------- 655
            |:           .|||.:|||:....|:..|    .:.:.|..|||         ||       
Human   576 AKLRLLVQHEINTLRAQEKHGLQPALLVHWAK----YLQKTGSGLNSFYGQLEYIGRSVHYWKKV 636

  Fly   656 -------DRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQD-LQSLAEEAV 712
                   .::|:...||.|:       :|.|:..:::...|.....|..|.|..| :....|:||
Human   637 LPLLKIIKKNSIPEPIDPLF-------KHFHSVDIQASEIVEYEEDAHITFAMLDAVNGNIEDAV 694

  Fly   713 TYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRREC---LQ 774
            |.|          |.....|...:|.:.:..::|   .:|..:..|        |.:.||   |.
Human   695 TAF----------ESIKSVVSYWNLALIFHRKAE---DIENDALSP--------EEQEECRNYLT 738

  Fly   775 KTQ----KLIKNDDKH-----PLIAAMHRHQQDRNS---RGIDNSFGSPDVHNNSSAYEDAEDDF 827
            ||:    |:|.:.|.:     .|...:...:|..||   ...|.|.|.|...|.|....|:|   
Human   739 KTRDYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSE--- 800

  Fly   828 YSHAAFSANR----SRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMRQDI 888
            ..|:..|..:    ..:..:.:|.||   .:.:::....:..|.:.           :||:::: 
Human   801 IKHSTPSPTKYSLSPSKSYKYSPETP---PRWTEDRNSLLNMICQQ-----------VEAIKKE- 850

  Fly   889 KVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQG 953
                         ::::|::|..:.:|...|....|.|.                          
Human   851 -------------MQELKLNSSKSASRHRWPTENYGPDS-------------------------- 876

  Fly   954 AIHPVVPNPYT-SGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLRTPP 1017
                 ||:.|. |..::|.|.|.:.     .||  |..::|:..||           :|:|..|.
Human   877 -----VPDGYQGSQTFHGAPLTVAT-----TGP--SVYYSQSPAYN-----------SQYLLRPA 918

  Fly  1018 APGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNI 1082
            |                                                                
Human   919 A---------------------------------------------------------------- 919

  Fly  1083 LESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTAVPP 1147
                            ..||..|:|..:...:|    ....||.:|......             
Human   920 ----------------NVTPTKGSSNTEFKSTK----EGFSIPVSADGFKFG------------- 951

  Fly  1148 PVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLS 1212
                                :|.|       .||..::|          .||...|....|    
Human   952 --------------------ISEP-------GNQEKKRE----------KPLENDTGFQAQ---- 975

  Fly  1213 VTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSK-------SSESPFSFKTQVAKA 1270
             .|..:.....::........:......|.||.|   |.||.|       |......|.::..|.
Human   976 -DISGRKKGRGVIFGQTSSTFTFADVAKSTSGEG---FQFGKKDLNFKGFSGAGEKLFSSRYGKM 1036

  Fly  1271 AAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTS 1335
            |         .:.|.||..:.:....:...:||.    .|:|::.:|::||:.||||||.:.::.
Human  1037 A---------NKANTSGDFEKDDDAYKTEDSDDI----HFEPVVQMPEKVELVTGEEGEKVLYSQ 1088

  Fly  1336 RAKLFRYVD---KEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDK 1397
            ..||||: |   ::|||||.|.:|||.::..|..|:||||:|..||||||.||.  |:|:.....
Human  1089 GVKLFRF-DAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITT--TMNLKPLSG 1150

  Fly  1398 DKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTK------------------ASEAAK 1444
            ..::.:|:|:||:|....|||...:|||.||||||:..|.:                  ...|||
Human  1151 SDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAK 1215

  Fly  1445 SKETVKPTVNTAEKGSTATAPAAFKSFVTS----------------TPAANSLINKPQEQTKTQP 1493
                   .:..||:..:....  ||:|:|:                ...|:....||..: .|.|
Human  1216 -------LIQRAEEMKSGLKD--FKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNAE-NTGP 1270

  Fly  1494 -----NPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFG 1553
                 |.|....|......:.||.|:|..|:|.....|.           |..||..  .|.||.
Human  1271 TLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFR-----------FDESTTG--SNFSFK 1322

  Fly  1554 TASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSS-DAEEEYVPTAQ-------FVPVI 1610
            :|.::.                       :..::||:|.:| ..:||.|.|.:       |.||:
Human  1323 SALSLS-----------------------KSPAKLNQSGTSVGTDEESVVTQEEERDGQYFEPVV 1364

  Fly  1611 ALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVH 1675
            .|||:|||.:|||||.|:|.|||::.|:||:..:|||||:|::|:|:: .|..:||::|||:||.
Human  1365 PLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQN-YDNKQVRIVMRRDQVL 1428

  Fly  1676 KLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSI 1740
            |||.|.|:.|:.........:....|.|.|::|.|.....||||||.||:...|.:...:|:.: 
Human  1429 KLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTA- 1492

  Fly  1741 GNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQ 1805
                                                                  :.||:.:.|  
Human  1493 ------------------------------------------------------QEKDSLITP-- 1501

  Fly  1806 SGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTA 1870
                     :::.||:                          |:|.|...:..|.....|..:|.
Human  1502 ---------HVSRSST--------------------------PRESPCGKIAVAILEETTRERTD 1531

  Fly  1871 ALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLP 1935
            .:.          ||....|     .|...|::..|:...:....||...|.:..|.:.|.....
Human  1532 VIQ----------GDDVADA-----ASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSSEKSK 1581

  Fly  1936 PTSKFSFGFGAAAAGDKDQAGDGATFNF---AAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNS 1997
            |     |.||.::|       .|:.|.|   |.:.:..:.|:|:..|. :.|..:||..:...||
Human  1582 P-----FVFGNSSA-------TGSLFGFSFNAPLKSNNSETSSVAQSG-SESKVEPKKCELSKNS 1633

  Fly  1998 TAAKEDED---NDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNESDWKE 2059
            ...:..:.   |.|.....||::..::          .||.|::..|               |  
Human  1634 DIEQSSDSKVKNLSASFPTEESSINYT----------FKTPEKEPPL---------------W-- 1671

  Fly  2060 RGLGDVKILRHRQTKKLRVVMRREQVFKIC--LNHVLNE----NVVYREKTETSWMFAVHDFSEG 2118
                      |.:..|..:|.:.....|..  ||.:|.|    |.|..|:.:..           
Human  1672 ----------HAEFTKEELVQKLRSTTKSADHLNGLLREIEATNAVLMEQIKLL----------- 1715

  Fly  2119 ESVLERFTLRFKNKEVAQGFMEAIKNALNE--TAKPIEDS----PVVGSVSQSTEANK------P 2171
            :|.:.|.. |.:.:|.:...:|.:||.|.:  ..||..:.    ||:.::.|.:...|      .
Human  1716 KSEIRRLE-RNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVA 1779

  Fly  2172 SQKNDGAAKSRG 2183
            ..:.:.|::|.|
Human  1780 QDEEENASRSSG 1791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup358NP_001247302.1 TPR <14..128 CDD:223533 33/122 (27%)
TPR repeat 58..90 CDD:276809 7/31 (23%)
Atrophin-1 <1030..1308 CDD:331285 35/284 (12%)
RanBD1_RanBP2_insect-like 1324..1442 CDD:269992 55/138 (40%)
RanBD2_RanBP2_insect-like 1620..1737 CDD:269993 49/116 (42%)
RanBP2-type Zn finger 1774..1793 CDD:275376 0/18 (0%)
Nucleoporin_FG2 1806..>1986 CDD:330420 32/182 (18%)
RanBP2-type Zn finger 1833..1861 CDD:275375 4/27 (15%)
zf-RanBP 1891..1917 CDD:279035 3/25 (12%)
RanBP2-type Zn finger 1894..1913 CDD:275376 3/18 (17%)
RanBD3_RanBP2_insect-like 2034..2148 CDD:269994 23/119 (19%)
RanBD4_RanBP2_insect-like 2571..2694 CDD:269995
RGPD5XP_006712857.2 TPR_11 85..152 CDD:290150 20/72 (28%)
TPR repeat 85..115 CDD:276809 7/31 (23%)
TPR_1 86..118 CDD:278916 6/33 (18%)
YRB1 1001..1193 CDD:227499 77/210 (37%)
RanBD2_RanBP2-like 1077..1193 CDD:269998 55/118 (47%)
RanBD3_RanBP2-like 1374..1490 CDD:270204 49/116 (42%)
Rab_bind 1667..1731 CDD:293309 17/102 (17%)
GRIP 1733..1775 CDD:279767 10/41 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 138 1.000 Domainoid score I4839
eggNOG 1 0.900 - - E1_COG5171
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 524 1.000 Inparanoid score I1253
Isobase 1 0.950 - 0.664386 Normalized mean entropy S1079
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D111047at33208
OrthoFinder 1 1.000 - - FOG0000925
OrthoInspector 1 1.000 - - otm40852
orthoMCL 1 0.900 - - OOG6_104909
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2180
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.680

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