DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup358 and RGPD8

DIOPT Version :9

Sequence 1:NP_001247302.1 Gene:Nup358 / 43041 FlyBaseID:FBgn0039302 Length:2718 Species:Drosophila melanogaster
Sequence 2:NP_001157935.1 Gene:RGPD8 / 727851 HGNCID:9849 Length:1765 Species:Homo sapiens


Alignment Length:2356 Identity:512/2356 - (21%)
Similarity:845/2356 - (35%) Gaps:773/2356 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRD-DAVGHNM 64
            |..::.:|:.:|..:||.....|::.:||...|:||.:.:||..|.:|:..|:.|:: |...|..
Human     1 MRRSKADVERYVASVLGLTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRF 65

  Fly    65 IATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITE-CARYWLDQANSLD 128
            :...|..  ..:..:|::.|:||::::|.|.::|:...|||.|.:   :|: .|:||:::|..| 
Human    66 LGLLYEL--EENTEKAVECYRRSVELNPTQKDLVLKIAELLCKND---VTDGRAKYWVERAAKL- 124

  Fly   129 LSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKM 193
            ..|:..::.|:.:  |.|..||       || .|.|..|:..||..||.||::.|:|:..|....
Human   125 FPGSPAIYKLKEQ--LLDCEGE-------DG-WNKLFDLIQSELYVRPDDVHVNIRLVELYRSTK 179

  Fly   194 KIDQAF--------NYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHT- 249
            ::..|.        |.||::.||..:|..|:.:.|      |..::..:..|.:||    |.:| 
Human   180 RLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEY------LESLQCLESDKSDWR----ATNTD 234

  Fly   250 ----LDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLH 310
                ...|:.|:|....:.::.:.|...|..|....:|:  .|:    |...|......|...::
Human   235 LLLAYANLMLLTLSTRDVQENRELLESFDSALQSAKSSL--GGN----DELSATFLEMKGHFYMY 293

  Fly   311 AVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGA 375
            |.:|:.|.....|..:|.:....|....|:.:||.                         ||:..
Human   294 AGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVP-------------------------RPKIK 333

  Fly   376 FRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRS 440
            .|..:.|:.||              |....|....||:.:..|....::.|....:...:|..:|
Human   334 LREGKAGQNLL--------------EMMACDRLSQSGHMLLSLSRGKQDFLKEVVETFANKIGQS 384

  Fly   441 QIYQQLFTHAEHKLKDTS---SHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLA 502
            .:|..||  :....||||   |..:..:.:|     .|.|..:..|::.|:.....|| ||: ..
Human   385 ALYDALF--SSQSPKDTSFLGSDDIGKIDVQ-----EPELEDLARYDVGAIRAHNGSL-QHL-TW 440

  Fly   503 LGTDPNKLGDAPRVVFYEGFQRDVKQ----------NLNYCGQDSISQVDVDLYL----YATTIQ 553
            ||...|.|...|      |.::.:||          .|.....:||..:|::::|    |.:.:|
Human   441 LGLQWNSLPALP------GIRKWLKQLFHRLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQ 499

  Fly   554 TRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRA 618
            .:.|.......|            :|..:||. :..||....|.:|||.|..|...:.: .||.|
Human   500 LKEKCNSHHSSY------------QPLCLPFP-VCKQLCTERQKSWWDAVCTLIHRKAV-PGNLA 550

  Fly   619 E-----------QRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNS---------RS-------- 655
            :           .|||.:|||:....|:..|    .:.:.|..|||         ||        
Human   551 KLRLLVQHEINTLRAQEKHGLQPALLVHWAK----YLQKTGSGLNSFYGQLEYIGRSVHYWKKVL 611

  Fly   656 ------DRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQD-LQSLAEEAVT 713
                  .::|:...||.|:       :|.|:..:::...|.....|..|.|..| :....|:|||
Human   612 PLLKIIKKNSIPEPIDPLF-------KHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVT 669

  Fly   714 YFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRREC---LQK 775
            .|          |.....|...:|.:.:..::|   .:|..:..|        |.:.||   |.|
Human   670 AF----------ESIKSVVSYWNLALIFHRKAE---DIENDALSP--------EEQEECRNYLTK 713

  Fly   776 TQ----KLIKNDDKH-----PLIAAMHRHQQDRNS---RGIDNSFGSPDVHNNSSAYEDAEDDFY 828
            |:    |:|.:.|.:     .|...:...:|..||   ...|.|.|.|...|.|....|:|   .
Human   714 TRDYLIKIIDDGDSNLSVVKKLPVPLESVKQMLNSVMQELEDYSEGGPLYKNGSLRNADSE---I 775

  Fly   829 SHAAFSANR----SRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMRQDIK 889
            .|:..|..:    ..:..:.:|.||   .:.:::....:..|.:.           :||::::  
Human   776 KHSTPSPTKYSLSPSKSYKYSPETP---PRWTEDRNSLLNMICQQ-----------VEAIKKE-- 824

  Fly   890 VLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQGA 954
                        ::::|::|..:.:|...|....|.|.                           
Human   825 ------------MQELKLNSSKSASRHRWPTENYGPDS--------------------------- 850

  Fly   955 IHPVVPNPYT-SGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLRTPPA 1018
                ||:.|. |..::|.|.|.:.     .||  |..::|:..||           :|:|..|.|
Human   851 ----VPDGYQGSQTFHGAPLTVAT-----TGP--SVYYSQSPAYN-----------SQYLLRPAA 893

  Fly  1019 PGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNIL 1083
                                                                             
Human   894 ----------------------------------------------------------------- 893

  Fly  1084 ESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTAVPPP 1148
                           ..||..|:|..:...:|    ....||.:|......              
Human   894 ---------------NVTPTKGSSNTEFKSTK----EGFSIPVSADGFKFG-------------- 925

  Fly  1149 VHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLSV 1213
                               :|.|       .||..::|          .||...|          
Human   926 -------------------ISEP-------GNQEKKRE----------KPLENDT---------- 944

  Fly  1214 TIPAQHIK-----PSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSK-------SSESPFSFKTQ 1266
            .:.||.|:     ..::........:......|.||.|   |.||.|       |......|.::
Human   945 GLQAQDIRGRKKGRGVIFGQTSSTFTFADVAKSTSGEG---FQFGKKDLNFKGFSGAGEKLFSSR 1006

  Fly  1267 VAKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDI 1331
            ..|.|         .:.|.||..:.:....:...:||.    .|:|::.:|::||:.||||||.:
Human  1007 YGKMA---------NKANTSGDFEKDDDAYKTEDSDDI----HFEPVVQMPEKVELVTGEEGEKV 1058

  Fly  1332 KFTSRAKLFRYVD---KEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVA 1393
            .::...||||: |   ::|||||.|.:|||.::..|..|:||||:|..||||||.||.  |:|:.
Human  1059 LYSQGVKLFRF-DAEVRQWKERGLGNLKILKNEVNGKLRMLMRREQVLKVCANHWITT--TMNLK 1120

  Fly  1394 NQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTK------------------AS 1440
            ......::.:|:|:||:|....|||...:|||.||||||:..|.:                  ..
Human  1121 PLSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTG 1185

  Fly  1441 EAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTS----------------TPAANSLINKPQEQT 1489
            .|||       .:..||:..:....  ||:|:|:                ...|:....||..: 
Human  1186 RAAK-------LIQRAEEMKSGLKD--FKTFLTNDQTKVTEEENKGSGTGVAGASDTTIKPNAE- 1240

  Fly  1490 KTQP-----NPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGN 1549
            .|.|     |.|....|......:.||.|:|..|:|.....|.           |..||..  .|
Human  1241 NTGPTLEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNLFR-----------FDESTTG--SN 1292

  Fly  1550 LSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSS-DAEEEYVPTAQ-------F 1606
            .||.:|.::.                       :..::||:|.:| ..:||.|.|.:       |
Human  1293 FSFKSALSLS-----------------------KSPAKLNQSGTSVGTDEESVVTQEEERDGQYF 1334

  Fly  1607 VPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRR 1671
            .||:.|||:|||.:|||||.|:|.|||::.|:||:..:|||||:|::|:|:: .|..:||::|||
Human  1335 EPVVPLPDLVEVSSGEENEQVVFSHRAEIYRYDKDVGQWKERGIGDIKILQN-YDNKQVRIVMRR 1398

  Fly  1672 EQVHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKA 1736
            :||.|||.|.|:.|:.........:....|.|.|::|.|.....||||||.||:...|.:...:|
Human  1399 DQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEA 1463

  Fly  1737 QQSIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATV 1801
            :.:                                                       :.||:.:
Human  1464 KTA-------------------------------------------------------QEKDSLI 1473

  Fly  1802 PPKQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTS 1866
            .|           :::.||:                          |:|.|...:..|.....|.
Human  1474 TP-----------HVSRSST--------------------------PRESPCGKIAVAVLEEITR 1501

  Fly  1867 VQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSG 1931
            .:|..:.          ||....|     .|...|::..|:...:....||...|.:..|.:.|.
Human  1502 ERTDVIQ----------GDDVADA-----ASEVEVSSTSETTTKAVVSPPKFVFVSESVKRIFSS 1551

  Fly  1932 LNLPPTSKFSFGFGAAAAGDKDQAGDGATFNF---AAMPAAVAPTTSIGSSSFTFSMTKPKPDQQ 1993
            ....|     |.||.::|       .|:.|.|   |.:.:..:.|:|:..|. :.|..:||..:.
Human  1552 EKSKP-----FAFGNSSA-------TGSLFGFSFNAPLKSNNSETSSVAQSG-SESKVEPKKCEL 1603

  Fly  1994 QPNSTAAKEDED---NDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNES 2055
            ..||...:..:.   |.|.....||::..::          .||.|::..|              
Human  1604 SKNSDIEQSSDSKVKNLSASFPTEESSINYT----------FKTPEKEPPL-------------- 1644

  Fly  2056 DWKERGLGDVKILRHRQTKKLRVVMRREQVFKIC--LNHVLNE----NVVYREKTETSWMFAVHD 2114
             |            |.:..|..:|.:.....|..  ||.:|.|    |.|..|:.:..       
Human  1645 -W------------HAEFTKEELVQKLRSTTKSADHLNGLLREIEATNAVLMEQIKLL------- 1689

  Fly  2115 FSEGESVLERFTLRFKNKEVAQGFMEAIKNAL-----------NETAKPI---------EDSPVV 2159
                :|.:.|.. |.:.:|.:...:|.:||.|           .|...|:         |:...:
Human  1690 ----KSEIRRLE-RNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKL 1749

  Fly  2160 GSVSQSTEANKPSQKN 2175
            .:|:|..|.| ||:.:
Human  1750 AAVAQDEEEN-PSRSS 1764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup358NP_001247302.1 TPR <14..128 CDD:223533 33/115 (29%)
TPR repeat 58..90 CDD:276809 7/31 (23%)
Atrophin-1 <1030..1308 CDD:331285 36/289 (12%)
RanBD1_RanBP2_insect-like 1324..1442 CDD:269992 55/138 (40%)
RanBD2_RanBP2_insect-like 1620..1737 CDD:269993 49/116 (42%)
RanBP2-type Zn finger 1774..1793 CDD:275376 0/18 (0%)
Nucleoporin_FG2 1806..>1986 CDD:330420 32/182 (18%)
RanBP2-type Zn finger 1833..1861 CDD:275375 4/27 (15%)
zf-RanBP 1891..1917 CDD:279035 3/25 (12%)
RanBP2-type Zn finger 1894..1913 CDD:275376 3/18 (17%)
RanBD3_RanBP2_insect-like 2034..2148 CDD:269994 23/130 (18%)
RanBD4_RanBP2_insect-like 2571..2694 CDD:269995
RGPD8NP_001157935.1 TPR 1 26..59 11/32 (34%)
TPR_11 59..126 CDD:290150 20/72 (28%)
TPR repeat 59..89 CDD:276809 7/31 (23%)
TPR 2 60..93 7/34 (21%)
TPR_1 60..92 CDD:278916 6/33 (18%)
TPR 3 648..681 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 760..804 10/49 (20%)
YRB1 975..1167 CDD:227499 77/210 (37%)
RanBD2_RanBP2-like 1051..1167 CDD:269998 55/118 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1216..1247 5/31 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1306..1330 8/23 (35%)
RanBD3_RanBP2-like 1348..1464 CDD:270204 49/116 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1621 9/41 (22%)
Rab_bind 1641..1705 CDD:293309 17/102 (17%)
GRIP 1707..1749 CDD:279767 7/41 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1746..1765 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 138 1.000 Domainoid score I4839
eggNOG 1 0.900 - - E1_COG5171
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 524 1.000 Inparanoid score I1253
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000925
OrthoInspector 1 1.000 - - otm40852
orthoMCL 1 0.900 - - OOG6_104909
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2180
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.720

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