Protein Alignment Nup358 and RGPD3

DIOPT Version :10

• Sequence 1: NP_001247302.1
• Gene: Nup358 / 43041
• FlyBaseID: FBgn0039302
• Length: 2718
• Species: Drosophila melanogaster
• Sequence 2: XP_016860227.1
• Gene: RGPD3 / 653489
• HGNCID: 32416
• Length: 1766
• Species: Homo sapiens
• Alignment Length: 2272
• Identity: 501/2272 - (22%)
• Similarity: 808/2272 - (35%)
• Gaps: 695/2272 - (30%)

  Fly    48 YLNGYLRVRD-DAVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNA 111
            |:..|:.||: |...|..:...|..  ..:..:|::.|:||::::|.|.::|:...|||.|.:
Human    56 YICTYINVREMDPRAHRFLGLLYEL--EENTEKAVECYRRSVELNPTQKDLVLKIAELLCKND-- 116

  Fly   112 SITE-CARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQAR 175
             :|: .|.||:::|..| ..|:..::.|:.:  |.|..||       || .|.|..|:..||..|
Human   117 -VTDGRAEYWVERAAKL-FPGSPAIYKLKEQ--LLDCEGE-------DG-WNKLFDLIQSELYVR 169

  Fly   176 PQDVNIRIQLLRSYVEKMKIDQAF--------NYALKTELESKNCTSQSNEWYEQIWMVLFKIEM 232
            |.||::.|:|:..|....::..|.        |.||::.||..:|..|:.:.|      |..::.
Human   170 PDDVHVNIRLVELYRSTKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEY------LESLQC 228

  Fly   233 AKDVKKNWRFWHFALHT-----LDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQ 292
            .:..|.:||    |.:|     ...|:.|:|....:.:|.:.|...|..|....:|:  .|:
Human   229 LESDKSDWR----ATNTDLLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSL--GGN--- 284

  Fly   293 RDLHQACIDHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIK 357
             |...|......|...:||.:|:.|.....|..:|.:....|....|:.:||.
Human   285 -DELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQWRALSELAALCYLIAFQVP------------ 336

  Fly   358 HCDAEQKQLIQMWRPQGAFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADS 422
                         ||:......:.|:.||              |....|....||:.:..|....
Human   337 -------------RPKIKLIKGEAGQNLL--------------EMMACDRLSQSGHMLLNLSRGK 374

  Fly   423 EELLASAHQQCLDKSWRSQIYQQLFTHAEHKLKDTS---SHLVRNLRLQLPLFEWPNLAHIENYE 484
            ::.|....:...:||.:|.:|..||  :....||||   |..:.|:.:|     .|.|..:..|:
Human   375 QDFLKVVVETFANKSGQSALYDALF--SSQSPKDTSFLGSDDIGNIDVQ-----EPELEDLARYD 432

  Fly   485 LQALVLPPHSLAQHVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQ----------DSIS 539
            :.|:.....|| ||: ..||...|.|...|      |.::.:||..::..|          :||.
Human   433 VGAIRAHNGSL-QHL-TWLGLQWNSLPALP------GIRKWLKQLFHHLPQETSRLETNAPESIC 489

  Fly   540 QVDVDLYL----YATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWW 600
            .:|::::|    |.:.:|.:.|.......|            :|..:|.. :..||....|.:||
Human   490 ILDLEVFLLGVVYTSHLQLKEKCNSHHSSY------------QPLCLPLP-VCKQLCTERQKSWW 541

  Fly   601 DLVVRLNSNQLITEGNRAE-----------QRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNSR 654
            |.|..|...:.: .||.|:           .|||.:|||:....|:..|.    :.::|..|||.
Human   542 DAVCTLIHRKAV-PGNSAKLRLLVQHEINTLRAQEKHGLQPALLVHWAKC----LQKMGSGLNSF 601

  Fly   655 SDRSSLEARIDTLYRQGFSILR--HQHNQQMESYVRVFKYGSAGSTAAWQDLQSLAEEAVTYFSE 717
            .|:.....|....:::...:|:  .:.|...|....:||:..:      .|:|  |.|.|.|..:
Human   602 YDQREYIGRSVHYWKKVLPLLKIIKKKNSIPEPIDPLFKHFHS------VDIQ--ASEIVEYEED 658

  Fly   718 K--MFRI-----GQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYS-ERRREC-- 772
            .  .|.|     |..|..:.....:...::|:..:...|...|.     .:.|..| |.:.||
Human   659 AHVTFAILDAVNGNIEDAMTAFESIKSVVSYWNLALIFHRKAED-----IANDALSPEEQEECKN 718

  Fly   773 -LQKTQ----KLIKNDD-------KHPLIAAMHRHQQDRNSRGIDN-SFGSPDVHNNSSAYEDAE 824
             |:||:    |::.:.|       |.|:.....:.......:.::| |.|.|...|.|....|:|
Human   719 YLRKTRGYLIKILDDSDSNLSVVKKLPVPLESVKEMLKSVMQELENYSEGGPLYKNGSLRNADSE 783

  Fly   825 DDFYSHAAFSANR----SRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMR 885
               ..|:..|..:    ..:..:.:|.||...|:....:                     ::.:|
Human   784 ---IKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSL---------------------LKMIR 824

  Fly   886 QDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSH 950
            |::|.:.|:       ::::|::|                             .:...|.:..:.
Human   825 QEVKAIKEE-------MQELKLNS-----------------------------SKSASHHRWPTE 853

  Fly   951 NQGAIHPVVPNPYT-SGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFLR 1014
            |.|.  ..||:.|. |..::|.|.|.:.     .||  |..::|:..||           :|:|.
Human   854 NYGP--DSVPDGYQGSQTFHGAPLTVAT-----TGP--SVYYSQSPAYN-----------SQYLL 898

  Fly  1015 TPPAPGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAP 1079
            .|.|                                       |.|
Human   899 RPAA---------------------------------------NVT------------------- 905

  Fly  1080 LNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTA 1144
                        ||.|..||                       ...||.....|
Human   906 ------------PTKGSSNT-----------------------EFKSTKEGFSI----------- 924

  Fly  1145 VPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQP 1209
                                  |||... |...::.       |.|....|..||...|....|
Human   925 ----------------------PVSADG-FKFGISE-------PGNQEKKSEKPLENDTGLQAQ- 958

  Fly  1210 TLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSK-------SSESPFSFKTQV 1267
                .|..:.....::........:......|.||.|   |.||.|       |......|.:|.
Human   959 ----DISGRKKGRGVIFGQTSSTFTFADVAKSTSGEG---FQFGKKDLNFKGFSGAGEKLFSSQY 1016

  Fly  1268 AKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIK 1332
            .|.|         .:.|.||..:.:....:...:||.    .|:|::.:|::||:.||||||.:.
Human  1017 GKMA---------NKANTSGDFEKDDDAYKTEDSDDI----HFEPVVQMPEKVELVTGEEGEKVL 1068

  Fly  1333 FTSRAKLFRYVDKE---WKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVAN 1394
            ::...||||: |.|   |||||.|.:|||.::..|..|:||:|:|..||||||.||.  |:|:..
Human  1069 YSQGVKLFRF-DAEVSQWKERGLGNLKILKNEVNGKVRMLMQREQVLKVCANHWITT--TMNLKP 1130

  Fly  1395 QDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKA-------------------- 1439
            .....::.:|:|:||:|....|||...:|||.||||||:..|.:.
Human  1131 LSGSDRAWMWSASDFSDGDAKLERLAAKFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGR 1195

  Fly  1440 -----SEAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQP-----N 1494
                 ..|.:.|..:|..........|..|....|...|....|:....||..: .|.|     |
Human  1196 AAKLIQRAEEMKSGLKDFKTFLTNDQTKVAEEENKGSGTGAAGASDTTIKPNAE-NTGPTLEWDN 1259

  Fly  1495 PDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFGTASAVG 1559
            .|....|......:.||.|:|..|:|.....| .|..:..||            |.||.:|.::.
Human  1260 YDLREDALDDSVSSSSVHASPLASSPVRKNLF-HFDESTTGS------------NFSFKSALSLS 1311

  Fly  1560 SGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQ-FVPVIALPDIVEVVTGEE 1623
            ..                ..|..|..:.:.....||..:|.....| |.||:.|||:|||.:|||
Human  1312 KS----------------PAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEE 1360

  Fly  1624 NEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETK 1688
            ||.|:|.|||:..|:||:..:|||||:|::|:|:: .|...||:||||:||.|||.|.|:.|:..
Human  1361 NEQVVFSHRAEFYRYDKDVGQWKERGIGDIKILQN-YDNKHVRILMRRDQVLKLCANHRITPDMS 1424

  Fly  1689 FTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKKEEVPSAA 1753
            .......:....|.|.|::|.|.....||||||.||:...|.:...:|:.:
Human  1425 LQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTA-------------- 1475

  Fly  1754 GEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLTT 1818
                                                     :.||:.:.|           :::.
Human  1476 -----------------------------------------QEKDSLITP-----------HVSR 1488

  Fly  1819 SSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGKSSMTSGF 1883
            ||:                          |:|.|...:..|.....|..:|..:.
Human  1489 SST--------------------------PRESPCGKIAVAVLEETTRERTDVIQ---------- 1517

  Fly  1884 GDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLPPTSKFSFGFGAAA 1948
            ||....|     .|...|::..|:...:....||.....:..|.:.|.....|     |.||.::
Human  1518 GDDVADA-----ASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSKP-----FAFGNSS 1572

  Fly  1949 AGDKDQAGDGATFNF---AAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDED---ND 2007
            |       .|:.|.|   |.:.:..:.|:|:..|. :.|..:||..:...||...:..:.   |.
Human  1573 A-------TGSLFGFSFNAPLKSNNSETSSVAQSG-SESKVEPKKCELSKNSDIEQSSDSKVKNL 1629

  Fly  2008 SQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAK---LYRLNESDWKERGLGDVKILR 2069
            |.....||::..::          .||.|::..|.|....|   :.:|:.:         .|...
Human  1630 SASFPTEESSINYT----------FKTPEKEPPLWYAEFTKEELVQKLSST---------TKSAD 1675

  Fly  2070 HRQTKKLRVVMRREQVFKICLNHVLNE----NVVYREKTETSWMFAVHDFSEGESVLERFTLRFK 2130
            |                   ||.:|.|    |.|..|:.:..           :|.:.|.. |.:
Human  1676 H-------------------LNGLLREIEATNAVLMEQIKLL-----------KSEIRRLE-RNQ 1709

  Fly  2131 NKEVAQGFMEAIKNALNE--TAKPIEDS----PVVGSVSQ-STEANKPSQKNDGAAKSRGGE 2185
            .:||:...:|.:||.|.:  ..||..:.    ||:.::.| |.|     :|...||.::|.|
Human  1710 EQEVSAANVEHLKNVLLQFIFLKPGSERERLLPVINTMLQLSLE-----EKGKLAAVAQGEE 1766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	LapB	<30..204	CDD:442196	47/165 (28%)
		TPR repeat	58..90	CDD:276809	7/31 (23%)
		PHA03247	<1030..1308	CDD:223021	40/284 (14%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	55/145 (38%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	50/116 (43%)
		ZnF_RBZ	1772..1796	CDD:197784	0/23 (0%)
		RanBP2-type Zn finger	1774..1793	CDD:275376	0/18 (0%)
		Nucleoporin_FG2	1806..>1985	CDD:435043	30/181 (17%)
		RanBP2-type Zn finger	1833..1861	CDD:275375	4/27 (15%)
		zf-RanBP	1891..1917	CDD:395516	3/25 (12%)
		RanBP2-type Zn finger	1894..1913	CDD:275376	3/18 (17%)
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	24/120 (20%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
RGPD3	XP_016860227.1	LapB	<61..230	CDD:442196	52/190 (27%)
		TPR repeat	68..96	CDD:276809	6/29 (21%)
		TPR repeat	101..132	CDD:276809	11/33 (33%)
		RanBD2_RanBP2-like	1060..1176	CDD:269998	55/118 (47%)
		RanBD3_RanBP2-like	1357..1473	CDD:270204	50/116 (43%)
		Rab_bind	1650..1714	CDD:435531	17/103 (17%)
		GRIP	1715..1758	CDD:460221	12/47 (26%)