DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup358 and RANBP2

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	XP_005264059.1	Gene:	RANBP2 / 5903	HGNCID:	9848	Length:	3258	Species:	Homo sapiens

Alignment Length:	3557	Identity:	775/3557 - (21%)
Similarity:	1205/3557 - (33%)	Gaps:	1331/3557 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRD-DAVGHNM 64
            |..::.:|:.::..:.|.....|::.:||...|:||.:.:||..|.:|:..|:.|:: |...|..
Human     1 MRRSKADVERYIASVQGSTPSPRQKSMKGFYFAKLYYEAKEYDLAKKYICTYINVQERDPKAHRF 65

  Fly    65 IATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITE-CARYWLDQANSLD 128
            :...|......|  :|::.|:||::::|.|.::|:...|||.|.:   :|: .|:|||::|..|
Human    66 LGLLYELEENTD--KAVECYRRSVELNPTQKDLVLKIAELLCKND---VTDGRAKYWLERAAKL- 124

  Fly   129 LSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKM 193
            ..|:..::.|:.:  |.|..||       || .|.|..|:..||..||.||::.|:|:..|....
Human   125 FPGSPAIYKLKEQ--LLDCEGE-------DG-WNKLFDLIQSELYVRPDDVHVNIRLVEVYRSTK 179

  Fly   194 KIDQAF--------NYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHT- 249
            ::..|.        |.||::.||..:|..|:.:.|      |..::..:..|.:||    |.:|
Human   180 RLKDAVAHCHEAERNIALRSSLEWNSCVVQTLKEY------LESLQCLESDKSDWR----ATNTD 234

  Fly   250 ----LDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLH 310
                ...|:.|:|....:.:|.:.|...|..|    .|::..|.   .|...|......|...:|
Human   235 LLLAYANLMLLTLSTRDVQESRELLQSFDSAL----QSVKSLGG---NDELSATFLEMKGHFYMH 292

  Fly   311 AVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGA 375
            |.:|:.|....::..:|.:....|....|:.:||.                         ||:..
Human   293 AGSLLLKMGQHSSNVQWRALSELAALCYLIAFQVP-------------------------RPKIK 332

  Fly   376 FRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRS 440
            ....:.|:.||              |....|....||:.:..|....::.|....:...:||.:|
Human   333 LIKGEAGQNLL--------------EMMACDRLSQSGHMLLNLSRGKQDFLKEIVETFANKSGQS 383

  Fly   441 QIYQQLFTHAEHKLKDTS---SHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLA 502
            .:|..||  :....||||   |..:.|:.::     .|.|..:..|::.|:.....|| ||: ..
Human   384 ALYDALF--SSQSPKDTSFLGSDDIGNIDVR-----EPELEDLTRYDVGAIRAHNGSL-QHL-TW 439

  Fly   503 LGTDPNKLGDAPRVVFYEGFQRDVKQ----------NLNYCGQDSISQVDVDLYL----YATTIQ 553
            ||...|.|...|      |.::.:||          .|.....:||..:|::::|    |.:.:|
Human   440 LGLQWNSLPALP------GIRKWLKQLFHHLPHETSRLETNAPESICILDLEVFLLGVVYTSHLQ 498

  Fly   554 TRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRA 618
            .:.|.......|            :|..:|.. :..||....|.:|||.|..|...:.: .||.|
Human   499 LKEKCNSHHSSY------------QPLCLPLP-VCKQLCTERQKSWWDAVCTLIHRKAV-PGNVA 549

  Fly   619 EQRAQLQHGLEAVRG--VNGPKADAII-----IFQLGKILNSRSD-------------------- 656
            :.|..:||.:..:|.  .:|.:...::     :.:.|..|||..|
Human   550 KLRLLVQHEINTLRAQEKHGLQPALLVHWAECLQKTGSGLNSFYDQREYIGRSVHYWKKVLPLLK 614

  Fly   657 ----RSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQD-LQSLAEEAVTYFS 716
                ::|:...||.|:       :|.|:..:::...|.....|..|.|..| :....|:|||.|
Human   615 IIKKKNSIPEPIDPLF-------KHFHSVDIQASEIVEYEEDAHITFAILDAVNGNIEDAVTAF- 671

  Fly   717 EKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRREC---LQKTQ- 777
                     |.....|...:|.:.:..::|   .:|..:..|        |.:.||   |:||:
Human   672 ---------ESIKSVVSYWNLALIFHRKAE---DIENDALSP--------EEQEECKNYLRKTRD 716

  Fly   778 ---KLIKNDD----------------KHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDA 823
               |:|.:.|                |..|.:.|...:        |.|.|.|...|.|....|:
Human   717 YLIKIIDDSDSNLSVVKKLPVPLESVKEMLNSVMQELE--------DYSEGGPLYKNGSLRNADS 773

  Fly   824 EDDFYSHAAFSANR----SRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAM 884
            |   ..|:..|..|    ..:..:.:|.||...|:....:
Human   774 E---IKHSTPSPTRYSLSPSKSYKYSPKTPPRWAEDQNSL------------------------- 810

  Fly   885 RQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQS 949
               :|::.::...::..::::|::|.::.:....|....|.|.   :.|.         :|..|:
Human   811 ---LKMICQQVEAIKKEMQELKLNSSNSASPHRWPTENYGPDS---VPDG---------YQGSQT 860

  Fly   950 HNQGAIHPVVPNPYTSGFYNGMPNTPSAQERFLQGPYGS------PMFNQNQMYNYYAAQAQAQA 1008
            .:...:......|  |.:|:   .:|:...::|..|..:      |::..|::    ..|....|
Human   861 FHGAPLTVATTGP--SVYYS---QSPAYNSQYLLRPAANVTPTKGPVYGMNRL----PPQQHIYA 916

  Fly  1009 QAQFLRTPPAPGS---IPPPNMFGPRNPNFGLPSM-FPPPTVPSVAPYIDAMGNFTQPPPSLIPP 1069
            ..|.:.|||...|   :....|:||       |:: |..|....::|..|...|:.....|..||
Human   917 YPQQMHTPPVQSSSACMFSQEMYGP-------PALRFESPATGILSPRGDDYFNYNVQQTSTNPP 974

  Fly  1070 PAQPAAPPAPLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIA 1134
                                 ||.||:|  |.|     ||....|:.....|:....|....|:.
Human   975 ---------------------LPEPGYF--TKP-----PIAAHASRSAESKTIEFGKTNFVQPMP 1011

  Fly  1135 GTVNPPATTAVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNN----------QPVEKEPPA 1189
            |                ..:.||:|.|.....|  .|..||....:          |.|.:.|||
Human  1012 G----------------EGLRPSLPTQAHTTQP--TPFKFNSNFKSNDGDFTFSSPQVVTQPPPA 1058

  Fly  1190 NV--------VITSSDPLPKPTTASVQPTLSVTIP-AQHIKPSLVQAPEQPAQSAQPAQPSVSGV 1245
            ..        ::||..||.....:..:|     || .|.|         .|..:......:|||:
Human  1059 AYSNSESLLGLLTSDKPLQGDGYSGAKP-----IPGGQTI---------GPRNTFNFGSKNVSGI 1109

  Fly  1246 GSLSFNFGS--------KSSESPFSF----KTQVAKAAAEKQKEQEEAEQNQSGATDPNKTLPQD 1298
             |.:.|.||        :.|:..|:|    |:.......|...:..|.:...:
Human  1110 -SFTENMGSSQQKNSGFRRSDDMFTFHGPGKSVFGTPTLETANKNHETDGGSA------------ 1161

  Fly  1299 TSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRY--VDKEWKERGTGVIKILCDK 1361
             ..||.|..|.|:|::||||::||:||||.|:..|.:||||||:  ..|||||||.|.:|||..|
Human  1162 -HGDDDDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDVESKEWKERGIGNVKILRHK 1225

  Fly  1362 ATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERFLVRFKT- 1425
            .:|..|:||||:|..|:||||.|:.|:.: ..|...| :|.:|.|.|:|||....|:..:||||
Human  1226 TSGKIRLLMRREQVLKICANHYISPDMKL-TPNAGSD-RSFVWHALDYADELPKPEQLAIRFKTP 1288

  Fly  1426 ---------------------------------------------------GELAEEFRVA---- 1435
                                                               |.|..||:||
Human  1289 EEAALFKCKFEEAQSILKAPGTNVAMASNQAVRIVKEPTSHDNKDICKSDAGNLNFEFQVAKKEG 1353

  Fly  1436 ---------FTKASEAAK----------SKETV-------------------------------- 1449
                     ...||.|.|          :||.|
Human  1354 SWWHCNSCSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKKEGH 1418

  Fly  1450 ----------KPTV-------NTA---EKGSTATAPAAFK------------SF----------- 1471
                      :|||       ||.   :.||:....|:||            .|
Human  1419 WDCSICLVRNEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSVFSTKEGQW 1483

  Fly  1472 ----------------------------VTSTPAANSLINKPQEQTKTQ---------------- 1492
                                        .||.|...|......|.:||.
Human  1484 DCSACLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMFAKKEGQWD 1548

  Fly  1493 ------------------PNPDPPATA------AKSLFGTLSVSAAP------------------ 1515
                              .|||.|:.:      |...|||...|.||
Human  1549 CSSCLVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFEGMFTKKEGQWDCS 1613

  Fly  1516 ---------------------------ATSAPAS------------------------------- 1522
                                       |.|.|||
Human  1614 VCLVRNEASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRN 1678

  Fly  1523 -----------------------ATPFASFS---------------------------------- 1530
                                   :||.:|.:
Human  1679 EASATKCIACQNPGKQNQTTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATK 1743

  Fly  1531 ----------------FTPNGS-------SGF--------------------------------- 1539
                            .||..|       |||
Human  1744 CIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNESSSLKCVACDASK 1808

  Fly  1540 -----------------------------GT-------STASPFGN----LSFGTASAVGS---- 1560
                                         ||       ..||.|||    ..||......|
Human  1809 PTHKPIAEAPSAFTLGSEMKLHDSSGSQVGTGFKSNFSEKASKFGNTEQGFKFGHVDQENSPSFM 1873

  Fly  1561 ----------------------------------------------------------------- 1560

Human  1874 FQGSSNTEFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENGTGFQAQDISGQKNGRGVIF 1938

  Fly  1561 GNNTTLFTTA-LIKDNTVQG--------------------KTLQQESQLNKSNSS-------DA- 1596
            |..::.||.| |.|..:.:|                    .:.|.....||:|:|       ||
Human  1939 GQTSSTFTFADLAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQYGKMANKANTSGDFEKDDDAY 2003

  Fly  1597 EEEYVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTD 1661
            :.|......|.||:.:|:.||:|||||:|.||:..|.||.|:|.|.::||||||||:|:|::..:
Human  2004 KTEDSDDIHFEPVVQMPEKVELVTGEEDEKVLYSQRVKLFRFDAEVSQWKERGLGNLKILKNEVN 2068

  Fly  1662 PNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDIC 1726
             .|:|:|||||||.|:|.|..:.........:....|..|.|.|:||.:.....||.:||:.::.
Human  2069 -GKLRMLMRREQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELA 2132

  Fly  1727 QQFLEAVQKAQQSIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCL 1791
            ::|.:..::.|:.:.:.|.  :.|....:..:..|....|.:.|:|..:.:...||
Human  2133 EEFKQKFEECQRLLLDIPL--QTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTN--------- 2186

  Fly  1792 ACQEPKDATVPPKQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAV 1856
                             ||    ...|...||.|             |....||:....||
Human  2187 -----------------DQ----TKVTEEENKGS-------------GTGAAGASDTTIKP---- 2213

  Fly  1857 VTASASAPTSVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTV 1921
             ....:.||      |.:....:..   ||...:|.|.|..|
Human  2214 -NPENTGPT------LEWDNYDLRE---DALDDSVSSSSVHA----------------------- 2245

  Fly  1922 PQKEKSLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGATFNFAAMPAAVAPTTSIGSSSFTFSMT 1986
                    |.|...|..|..|.||.:..|          ||| :..:|::|:.|
Human  2246 --------SPLASSPVRKNLFRFGESTTG----------FNF-SFKSALSPSKS----------- 2280

  Fly  1987 KPKPDQQQPNSTAAKEDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYR 2051
               |.:...:.|:...||::|..: |||.:..||.||:||||.::|.:|||:|::::.|:|||||
Human  2281 ---PAKLNQSGTSVGTDEESDVTQ-EEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYR 2341

  Fly  2052 LNE--SDWKERGLGDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYR--EKTETSWMFAV 2112
            .::  ..|||||:||:|||::...|::|:||||:||.|:|.||.:..::..:  :.||..|::..
Human  2342 YDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMTLQNMKGTERVWLWTA 2406

  Fly  2113 HDFSEGESVLERFTLRFKNKEVAQGFMEAIKNA-------------------------------- 2145
            .||::||..:|...:|||.::||..|.:....|
Human  2407 CDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAV 2471

  Fly  2146 LNETAKPIED----------------------------SP---VVGSVSQ----STEANKPSQKN 2175
            |.||.:...|                            ||   |.||.|.    |:|.:||....
Human  2472 LEETTRERTDVIQGDDVADATSEVEVSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFG 2536

  Fly  2176 DGAA-------------KSRGGE-SEVLDVGKTSSVRPTTHEVIPPLPMTLPLLTLPQPLAKPND 2226
            :.:|             ||...| |.|...|..|.|.|...|                 |:|.:|
Human  2537 NSSATGSLFGFSFNAPLKSNNSETSSVAQSGSESKVEPKKCE-----------------LSKNSD 2584

  Fly  2227 YQTPATILFKG--SSLSRNNSSASEASKTPSSAFIFG-----------STDKSEPGKDA------ 2272
            .:..:....|.  :|.....||.:...|||...|.|.           ||..|:|...|
Human  2585 IEQSSDSKVKNLFASFPTEESSINYTFKTPEKGFNFSLFKSNPMAFWTSTPSSQPESKAKEKKKP 2649

  Fly  2273 ---------------GPLANLQKLA-------------------SGEGQGN---------VLGSI 2294
                           .|.|..:.||                   |.|.:.:         :.|.:
Human  2650 EDSPSDDDVLIVYELTPTAEQKALATKLKLPPTFFCYKNRPDYVSEEEEDDEDFETAVKKLNGKL 2714

  Fly  2295 FRSGSS-----NENSSDGSVKFFFGGGNKAAEQQKKDSSESVFGGNKADSQSPATQEAPKLAFGG 2354
            :..||.     .||::|...:.......|...::|.          |||     |.:.|...|.|
Human  2715 YLDGSEKCRPLEENTADNEKECIIVWEKKPTVEEKA----------KAD-----TLKLPPTFFCG 2764

  Fly  2355 IAAPVFGDANPFGGHKVNLQK----------SDGKEEPKSIIGGTPLLFGGSNAFGIPKIETQSP 2409
            :.:....|.......:..|||          |..|.:.:.|...|..::.|.....:|
Human  2765 VCSDTDEDNGNGEDFQSELQKVQEAQYFVTSSLQKSQTEEITSTTDSVYTGGTEVMVP------- 2822

  Fly  2410 AKDFVFGSAPAFGQMATFSFTAAKNEKEKDIT--------SNNTTDLKAEGKEKKELVPETTS-- 2464
                              ||  .|:|:...||        |:.|.|...:...:||:..::||
Human  2823 ------------------SF--CKSEEPDSITKSISSPSVSSETMDKPVDLSTRKEIDTDSTSQG 2867

  Fly  2465 -----TFADLAKTGSTFADLASNPGGTFADLANKTGNDFANLSANSQGTTVGFNKSAGGGFYNLT 2524
                 :|...:.||.:||||||:..|.||..:......:||..|...||.....:|||
Human  2868 ESKIVSFGFGSSTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGTQSVGTQSAG------- 2925

  Fly  2525 HQNAFKNFESPQATEECDDDGDATTDDNYDPHYDAIVELPDEIVVTTGEENETKLFGERAKLYRY 2589
                        ...|.:|..|.....|.|.|::.||.|| |:.|.:|||:|..||.|||||||:
Human  2926 ------------KVGEDEDGSDEEVVHNEDIHFEPIVSLP-EVEVKSGEEDEEILFKERAKLYRW 2977

  Fly  2590 DAESKQWKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGY 2654
            |.:..||||||||:||:|.|.....:|::||::|:.|:..|..|:.::::..:|....:.:|...
Human  2978 DRDVSQWKERGVGDIKILWHTMKNYYRILMRRDQVFKVCANHVITKTMELKPLNVSNNALVWTAS 3042

  Fly  2655 NYAVDAEGKVDTEGVLERLACRFAKEEIASEFLNTVNSCIKRAKALQ 2701
            :|| |.|.||      |:||.||..:|:|..|..|...|.:....||
Human  3043 DYA-DGEAKV------EQLAVRFKTKEVADCFKKTFEECQQNLMKLQ 3082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533	34/115 (30%)
		TPR repeat	58..90	CDD:276809	8/31 (26%)
		Atrophin-1	<1030..1308	CDD:331285	63/309 (20%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	60/184 (33%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	46/116 (40%)
		RanBP2-type Zn finger	1774..1793	CDD:275376	2/18 (11%)
		Nucleoporin_FG2	1806..>1986	CDD:330420	34/179 (19%)
		RanBP2-type Zn finger	1833..1861	CDD:275375	5/27 (19%)
		zf-RanBP	1891..1917	CDD:279035	4/25 (16%)
		RanBP2-type Zn finger	1894..1913	CDD:275376	2/18 (11%)
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	48/149 (32%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995	50/122 (41%)
RANBP2	XP_005264059.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4839
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1253
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46755
OrthoDB	1	1.010	-	-		D111047at33208
OrthoFinder	1	1.000	-	-		FOG0000925
OrthoInspector	1	1.000	-	-		otm40852
orthoMCL	1	0.900	-	-		OOG6_104909
Panther	1	1.100	-	-	LDO	PTHR23138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3834
SonicParanoid	1	1.000	-	-		X2180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870