DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup358 and RANBP1

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	NP_001265568.1	Gene:	RANBP1 / 5902	HGNCID:	9847	Length:	278	Species:	Homo sapiens

Alignment Length:	209	Identity:	71/209 - (33%)
Similarity:	111/209 - (53%)	Gaps:	29/209 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  2002 EDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRL-NESD---WKERGL 2062
            ||.|..::..:|..::..|.|::.||:: ::||.|||||.|:..:|||:|. :|:|   |||||.
Human    86 EDHDTSTENTDESNHDPQFEPIVSLPEQ-EIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGT 149

  Fly  2063 GDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYREK--TETSWMFAVH-DFSEGESVLER 2124
            ||||:|:|::...:|::|||::..|||.||.:...:..:..  ::.:|::..| ||::.....|.
Human   150 GDVKLLKHKEKGAIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPEL 214

  Fly  2125 FTLRFKNKEVAQGFMEAIKNALNETAKPIEDSPVVGSVSQSTEANKPSQKNDGAAKSRGGESEVL 2189
            ..:||.|.|.||.|    |....|..|.||:          .|....|.|||.|.|       |.
Human   215 LAIRFLNAENAQKF----KTKFEECRKEIEE----------REKKAGSGKNDHAEK-------VA 258

  Fly  2190 DVGKTSSVRPTTHE 2203
            :..:..||:..|.|
Human   259 EKLEALSVKEETKE 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	46/120 (38%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
RANBP1	NP_001265568.1	RanBD_RanBP1	101..237	CDD:270000	52/140 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159286
Domainoid	1	1.000	105	1.000	Domainoid score	I6642
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.664386	Normalized mean entropy	S1079
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000925
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3834
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720