DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup358 and RanBP3

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	NP_651178.1	Gene:	RanBP3 / 42804	FlyBaseID:	FBgn0039110	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	105/458 - (22%)
Similarity:	166/458 - (36%)	Gaps:	105/458 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1127 TAPAPPIAGTVNPPATTAVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKE----- 1186
            |..|..:.|.|..||..|.....:....:||...              :.||.|.|..:|
  Fly    19 TLKASRLGGAVLRPAVLANSSGSNNSSTSPSAGE--------------DSALLNNPFLRESKDDD 69

  Fly  1187 PPANVVITSS------------------DPLPKPTTASVQPTLSVTIPAQHIKPSL--------- 1224
            ....||.|.|                  |||.|..:..::.: |:...|::..|::
  Fly    70 DDEEVVATGSAAAESTGDKEDDDVDERPDPLTKLRSNGIERS-SMFAAAKNNMPNVQSSGFVFGQ 133

  Fly  1225 -----VQAPEQPAQSAQP----AQPSVSGVGSLSFNFGSKSSESPFSFKTQVAKAAAEKQKEQEE 1280
                 |.||.....:|:|    |..|||...:.|.:..:.||.:|..|.:.:..||...:..:..
  Fly   134 NVHERVVAPNAEQVTAEPDADTAASSVSAQEAASSSTAATSSSAPLLFSSVIQNAAQTTETSEAA 198

  Fly  1281 AEQNQSGATDPNKTLPQDTSADDY-----DPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLF 1340
            |..:...::..||...:..|..|.     :.|...:..    :|||..||||.|........|||
  Fly   199 ASSSICSSSSNNKESAEAKSLTDVAREYEESRAQKRKY----EEVETFTGEEDEINIIDVSCKLF 259

  Fly  1341 RYVDKEWKERGTGVIKILCDK-ATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLW 1404
            .:::..|:|||.|.:::...| ..|.|||:.|.....::..|..:.|.:....|:|    |||..
  Fly   260 AFLNSNWEERGRGSLRLNDAKDLRGDSRVVFRTSGNLRLLLNTKVWAAMVAERASQ----KSLRL 320

  Fly  1405 AANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASEAAKSKETVKPTVNTAEKGSTATAPAAFK 1469
            .|   .|....::.||...:..::|:..:         |.|:...|..|:..|:.|...|    |
  Fly   321 TA---IDNSGVVKIFLAMGRPADIAQLHK---------ALSERIAKRKVSHPEECSVEEA----K 369

  Fly  1470 SFVTSTPAANSLINKPQEQTKTQPNPDPPATAAKSLFGTLSVSA------------APATSAPAS 1522
            :.|.|..||:.     |.::.|..:.|..|....|  |.:|..|            .|.:||...
  Fly   370 NGVASEAAASL-----QPESTTHDDEDEDAAPGPS--GAISAEADSYGPSPKKVIVQPDSSADVP 427

  Fly  1523 ATP 1525
            ..|
  Fly   428 VPP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285	46/226 (20%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	31/118 (26%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
RanBP3	NP_651178.1	RanBD_RanBP3	243..352	CDD:270001	33/124 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23138
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940