Protein Alignment Nup358 and GCC185

DIOPT Version :9

• Sequence 1: NP_001247302.1
• Gene: Nup358 / 43041
• FlyBaseID: FBgn0039302
• Length: 2718
• Species: Drosophila melanogaster
• Sequence 2: NP_001097755.1
• Gene: GCC185 / 41459
• FlyBaseID: FBgn0037979
• Length: 1135
• Species: Drosophila melanogaster
• Alignment Length: 1090
• Identity: 196/1090 - (17%)
• Similarity: 354/1090 - (32%)
• Gaps: 374/1090 - (34%)

  Fly     1 MFTTRKEVDAHVHKMLGKLQPGRERDIKGL-------------AVARLYMKVQEYPKAI---EYL 49
            :|.|:.:...::.|::.|.:..::|.::.|             .:.|.::|.||:.:.:   ..|
  Fly   364 LFQTKLDQMQNLVKVIAKERDNQQRKLQELEAICIELRQHNEDLLTRYHLKEQEHGELLTEMREL 428

  Fly    50 NGYLRVRDDAVGHNMIATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASIT 114
            |..|:.|.||:         |||.  :..||....||.::.....|:.........:|:..:.:.
  Fly   429 NEALKGRGDAI---------SRLQ--EQHEAEVKRQRDLEAQLSNSQQAAQEKLQKIKQLQSRVE 482

  Fly   115 ECARYWLDQANSLDLSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDV 179
            |     |:|||                   ||:..:...||       |:         :|.:::
  Fly   483 E-----LEQAN-------------------ADAQSDVLSTS-------TI---------SRAEEL 507

  Fly   180 NIRIQLLRSYVEKMKIDQAFNYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWH 244
            :...:|...|.||....:|....||.:|:.:  |.|.|| .||...:..::|..|
  Fly   508 SRLRELDEGYEEKYHKLRAIAAKLKKKLQEQ--TQQLNE-MEQSGALKEELEAIK---------- 559

  Fly   245 FALHTLDRLVQLSLEGS-GLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLL 308
                    |.|..|:.. ..|.:..|..:..:.: |.|:.:....:|.::.|.:.     :.:|.
  Fly   560 --------LAQAQLQQDLNAARAENQKLKSKEKV-KHSSVLNLEIEAAEKSLSEV-----SAKLT 610

  Fly   309 LHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQ 373
            ..:..|...:|.||:|...:..||..:.:|          :.:.|....| ..|.|:.|
  Fly   611 AKSSELEAVKESLASKENTIVQLRKEIAIL----------EEAKNGEAAH-SLELKEQI------ 658

  Fly   374 GAFRCAQLGRTLLGCLDRSQMEIK---NDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLD 435
                            ||.|:::|   :.::.| ..:||:..:.:       |:....|.|..|.
  Fly   659 ----------------DRMQVQVKDAVHSKQQA-LTQNKDLEHGV-------EQAKLEAEQLRLQ 699

  Fly   436 KSWRSQIYQQLFTHAEHKL----KDTSSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLA 496
            .|..:|.|:.....|..:|    ::...||....||:
  Fly   700 LSESAQQYESKLNTATQQLLSQTQELEMHLAEQKRLE---------------------------- 736

  Fly   497 QHVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQDSISQVDVDLYLYATTIQTRRKLQIQ 561
                       ..|.:|.|.:      .|::  :.|                     |..||:.|
  Fly   737 -----------TALRNAERAL------EDLR--VEY---------------------TEYKLKAQ 761

  Fly   562 REVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGN--RAEQRAQL 624
            ..:..:.|.|:..                    ||....:||....|.:.:...|  ||.:.|||
  Fly   762 SVLRKNQNKGSNR--------------------EQELEEELVALRESERNLRASNDGRAARLAQL 806

  Fly   625 QHGLEAVRGVNGPKADAIIIFQLGKILNSRSDRSSLEARIDTLYRQGFSILRHQHNQQMESYVRV 689
            ...:|.:|..|..             |..||  ..|.:.:|.|.:|
  Fly   807 DSQIEELRQDNTD-------------LQKRS--KELVSLVDELRQQ------------------- 837

  Fly   690 FKYGSAGSTAAWQDLQSLAEEAVTYFSEKMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEES 754
                        .||.||..:....|...:.:  |:.|.:||:             :|.|.|:.:
  Fly   838 ------------NDLLSLENQRQLQFQHDLMQ--QHRQQVDEL-------------DAGHQLQLT 875

  Fly   755 SKLPRTSRDRYSERRRECLQKTQKLIKNDDKHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSA 819
                         :.:|.|::.||:..|..:|...:|          ..:|.   ||:.......
  Fly   876 -------------QVQEQLEEAQKMQANVSQHTTASA----------ASVDT---SPEQAKIDYL 914

  Fly   820 YEDAEDDFYSHAA------FSANR-----SRRQLEVTPVTPIVMAQPSQEMEQAVKQIS---KSL 870
            ..|.|.....||.      .:|.|     |||..:..|:..::....:|.....|..||   :|:
  Fly   915 LMDHETGLDGHAGDVSLAQLAAQRKISTASRRSHDFMPLDELLNTSMNQITSDTVTTISNFGRSV 979

  Fly   871 CVLKDDVSVGMEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFII---E 932
            ...:|:.:  ..|.|.|..|.:.:....::     ::|.:::..:.:....|....||..:   .
  Fly   980 SQQEDEEA--EMAARGDFSVQSAQLQATKE-----RLSIQESRVKHLTALLAENEQDLAKLTQMN 1037

  Fly   933 DALAE---HQQQQQHQQQQSHNQGAIHPVVPNPYTSGFYNGMPNTPSAQERFLQGPYGSPMF--- 991
            |.|.|   .|::.:.::|..||         :.|....:.......:..||....|..:.:.
  Fly  1038 DMLKEELRRQERSEEREQHMHN---------SEYLKNVFLKFLTLNNVDERQRLVPVLNTILRLS 1093

  Fly   992 -NQNQMYNYYA------AQAQAQAQAQFLRTPPAPGSIPPPNMFGPRNPN 1034
             |:.:|.|..|      |...:::...||......||        |.|.|
  Fly  1094 RNEMEMLNCVAKGQKVSADGSSRSWTGFLTAWSGGGS--------PNNNN 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533	28/129 (22%)
		TPR repeat	58..90	CDD:276809	9/31 (29%)
		Atrophin-1	<1030..1308	CDD:331285	3/5 (60%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
GCC185	NP_001097755.1	SMC_prok_B	35..813	CDD:274008	118/655 (18%)
		TMPIT	458..>548	CDD:285135	26/132 (20%)
		GRIP	1058..1100	CDD:279767	7/50 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900