DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup358 and RGPD1

DIOPT Version :9

Sequence 1:NP_001247302.1 Gene:Nup358 / 43041 FlyBaseID:FBgn0039302 Length:2718 Species:Drosophila melanogaster
Sequence 2:XP_016859592.1 Gene:RGPD1 / 400966 HGNCID:32414 Length:1805 Species:Homo sapiens


Alignment Length:2352 Identity:515/2352 - (21%)
Similarity:827/2352 - (35%) Gaps:802/2352 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GKLQP------------GRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRD-DAVGHNMIATC 68
            |.|.|            |.:..::|...|:||.:.:||..|.:|:..||.|:: |...|..:...
Human    49 GSLSPVIAPKKARPSETGSDDKLRGFYFAKLYYEAKEYDLAKKYVCTYLSVQERDPRAHRFLGLL 113

  Fly    69 YSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITE-CARYWLDQANSLDLSGN 132
            |..  ..:..:|::.|:||::::|.|.::|:...|||.|.:   :|: .|:||:::|..| ..|:
Human   114 YEL--EENTEKAVECYRRSLELNPPQKDLVLKIAELLCKND---VTDGRAKYWVERAAKL-FPGS 172

  Fly   133 KQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKMKIDQ 197
            ..::  :::.:|.|..||       || .|.|...:..||..||.||::.|:|:..|....::..
Human   173 PAIY--KLKEHLLDCEGE-------DG-WNKLFDWIQSELYVRPDDVHMNIRLVELYRSNKRLKD 227

  Fly   198 AF--------NYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWRFWHFALHT----- 249
            |.        |.||::.||..:|..|:.:.|      |..::..:..|.:||    |.:|     
Human   228 AVARCHEAERNIALRSSLEWNSCVVQTLKEY------LESLQCLESDKSDWR----ATNTDLLLA 282

  Fly   250 LDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTGQLLLHAVTL 314
            ...|:.|:|....:.:|.:.|...|..|....:|:  .|:    |...|......|...:||.:|
Human   283 YANLMLLTLSTRDVQESRELLESFDSALQSAKSSL--GGN----DELSATFLEMKGHFYMHAGSL 341

  Fly   315 IFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQMWRPQGAFRCA 379
            :.|.....|..:|.:....|....::.:||.                         ||:......
Human   342 LLKMGQHGNNVQWQALSELAALCYVIAFQVP-------------------------RPKIKLIKG 381

  Fly   380 QLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQCLDKSWRSQIYQ 444
            :.|:.||              |....|....||:.:..|....::.|....:...:||.:|.:|.
Human   382 EAGQNLL--------------EMMACDRLSQSGHMLLNLSRGKQDFLKEVVETFANKSGQSVLYN 432

  Fly   445 QLFTHAEHKLKDTS---SHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQHVYLALGTD 506
            .||  :....||||   |..:.|:.:|     .|.|..:..|::.|:.....|| ||: ..||..
Human   433 ALF--SSQSSKDTSFLGSDDIGNIDVQ-----EPELEDLARYDVGAIQAHNGSL-QHL-TWLGLQ 488

  Fly   507 PNKLGDAPRVVFYEGFQRDVKQNLNYCGQ----------DSISQVDVDLYL----YATTIQTRRK 557
            .|.|...|      |.::.:||..::..|          :||..:|::::|    |.:.:|.:.|
Human   489 WNSLPALP------GIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEK 547

  Fly   558 LQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLITEGNRAE--- 619
            .......|            :|..:|.. :..:|....|.:|||.|..|...:.: .||.||   
Human   548 CNSHHSSY------------QPLCLPLP-VCKRLCTERQKSWWDAVCTLIHRKAV-PGNSAELRL 598

  Fly   620 --------QRAQLQHGLEAVRGVNGPKADAIIIFQLGKILNSRSD-------------------- 656
                    .|||.:|||:....|:..|.    :.::|:.|||..|                    
Human   599 VVQHEINTLRAQEKHGLQPALLVHWAKC----LQKMGRGLNSSYDQQEYIGRSVHYWKKVLPLLK 659

  Fly   657 ---RSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSAGSTAAWQD-LQSLAEEAVTYFSE 717
               ::|:...||.|:       :|.|:..:::...|.....|..|.|..| :....|:|||.|  
Human   660 IIKKNSIPEPIDPLF-------KHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAF-- 715

  Fly   718 KMFRIGQYEQFLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRREC---LQKTQ-- 777
                    |.....|...:|.:.:..::|   .:|..:..|        |.:.||   |:||:  
Human   716 --------ESIKSVVSYWNLALIFHRKAE---DIENDAVFP--------EEQEECKNYLRKTRDY 761

  Fly   778 --KLIKNDD----------------KHPLIAAMHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDAE 824
              |:|.:.|                |..|.:.|...:        |.|.|.|...|.|....|:|
Human   762 LIKIIDDSDSNLSVVKKLPVPLESVKEMLKSVMQELE--------DYSEGGPLYKNGSLRNADSE 818

  Fly   825 DDFYSHAAFSANR----SRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCVLKDDVSVGMEAMR 885
               ..|:..|..:    ..:..:.:|.||...|:....:.       |.:|              
Human   819 ---IKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLR-------KMIC-------------- 859

  Fly   886 QDIKVLTEKFTGLEDLLKKIKISSRDT-PTRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQS 949
            |::|.:|:        |...|.:||.. ||.:..|.:                            
Human   860 QEVKAITK--------LNSSKSASRHRWPTENYGPDS---------------------------- 888

  Fly   950 HNQGAIHPVVPNPYT-SGFYNGMPNTPSAQERFLQGPYGSPMFNQNQMYNYYAAQAQAQAQAQFL 1013
                     ||:.|. |..::|.|.|.:.     .||  |..::|:..||           :|:|
Human   889 ---------VPDGYQGSQTFHGAPLTVAT-----TGP--SVYYSQSPAYN-----------SQYL 926

  Fly  1014 RTPPAPGSIPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPA 1078
            ..|.|  ::.|..  |..|..|.                 .....|:                  
Human   927 LRPAA--NVTPTK--GSSNTEFK-----------------STKEGFS------------------ 952

  Fly  1079 PLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATT 1143
                      :|:...||      .||.|                                    
Human   953 ----------IAVSADGF------KFGIS------------------------------------ 965

  Fly  1144 AVPPPVHIPQVAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQ 1208
                                                       .|.|....|..||...|....|
Human   966 -------------------------------------------EPGNQEKKSEKPLENDTGFQAQ 987

  Fly  1209 PTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLSFNFGSKSSE-SPFS------FKTQ 1266
                 .|..|.....::........:......|.||.|   |.||.|... ..||      |.:|
Human   988 -----DISGQKNGRGVIFGQTSSTFTFADVAKSTSGEG---FQFGKKDPNFKGFSGAGEKLFSSQ 1044

  Fly  1267 VAKAAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDI 1331
            ..|.|         .:.|.||..:.:....:...:||.    .|:|::.:|::||:.||||||.:
Human  1045 CGKMA---------NKANTSGDFEKDDDACKTEDSDDI----HFEPVVQMPEKVELVTGEEGEKV 1096

  Fly  1332 KFTSRAKLFRYVDKE---WKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVA 1393
            .::...||||: |.|   |||||.|.:|||.::..|..|:||||||..||||||.||.  |:|:.
Human  1097 LYSQGVKLFRF-DAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITT--TMNLK 1158

  Fly  1394 NQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTK------------------AS 1440
            ......::.:|.|:||:|....|||...:|||.||||||:..|.:                  ..
Human  1159 PLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTG 1223

  Fly  1441 EAAKSKETVKPTVNTAEKGSTATAPAAFKSFVTS--------------TPAANSLINKPQEQTKT 1491
            .|||       .:..||:..:....  ||:|:|:              |.||.:      ..|..
Human  1224 RAAK-------LIQRAEEMKSGLKD--FKTFLTNDQTKVTEEENKGSGTGAAGA------SDTTI 1273

  Fly  1492 QPNP------------DPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGSSGFGTSTA 1544
            :|||            |....|......:.||..:|..|:|.....|.    ....::||     
Human  1274 KPNPENTGPTLEWDNYDLREDALDDNVSSSSVHDSPLASSPVRKNIFR----FDESTTGF----- 1329

  Fly  1545 SPFGNLSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQ-FVP 1608
                |.||.:|.::...                ..|..|..:.:.....||..:|.....| |.|
Human  1330 ----NFSFKSALSLSKS----------------PAKLNQSGTSVGTDEESDVTQEEERDGQYFEP 1374

  Fly  1609 VIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQ 1673
            |:.|||:|||.:|||||.|:|.|||:|.|:||:..:|||||:|::|:|:: .|..:||::|||:|
Human  1375 VVPLPDLVEVSSGEENEQVVFSHRAELYRYDKDVGQWKERGIGDIKILQN-YDNKQVRIVMRRDQ 1438

  Fly  1674 VHKLCCNQRLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQ 1738
            |.|||.|.|:.|:.........:....|.|.|::|.|.....||||||.||:...|.:...:|:.
Human  1439 VLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKT 1503

  Fly  1739 SIGNEPKKEEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPP 1803
            :                                                       :.||:.:.|
Human  1504 A-------------------------------------------------------QEKDSLITP 1513

  Fly  1804 KQSGLDQGNALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQ 1868
                       :::.||:                          |:|.|...:..|.....|..:
Human  1514 -----------HVSRSST--------------------------PRESPCGKIAVAVLEETTRER 1541

  Fly  1869 TAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPK----NDTVPQ---KEK 1926
            |..:.          ||....|     .|...|::..|:...:....||    :::|.:   .||
Human  1542 TDVIQ----------GDDVADA-----ASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEK 1591

  Fly  1927 SLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGATFNF---AAMPAAVAPTTSIGSSSFTFSMTKP 1988
            |          :.|:||..:|.         |:.|.|   |.:.:..:.|:|:..|. :.|..:|
Human  1592 S----------NPFAFGNSSAT---------GSLFGFSFNAPLKSNDSETSSVAQSG-SESKVEP 1636

  Fly  1989 KPDQQQPNSTAAKEDEDNDSQ--------EVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVH 2045
            |..:...||..   ::.:||:        .:||...|..|            ||.|::..|    
Human  1637 KKCELSKNSDI---EQSSDSKVKNLSASFPMEESSINYTF------------KTPEKEPPL---- 1682

  Fly  2046 KAKLYRLNESDWKERGLGDVKILRHRQTKKLRVVMRREQVFKIC--LNHVLNENVVYREKTETSW 2108
                       |            |.:..|..:|.:.....|..  ||.:|.|       ||.:.
Human  1683 -----------W------------HAEFTKEELVQKLSSTTKSADQLNGLLRE-------TEATS 1717

  Fly  2109 MFAVHDFSEGESVLERFTLRFKNKEVAQGFMEAIKNALNE--TAKPIEDS----PVVGSVSQSTE 2167
            ...:......:|.:.|..   :|:|.:...:|.:||.|.:  ..||..:.    ||:.::.|.: 
Human  1718 AVLMEQIKLLKSEIRRLE---RNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLS- 1778

  Fly  2168 ANKPSQKNDGAA 2179
               |.:|...||
Human  1779 ---PEEKGKLAA 1787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup358NP_001247302.1 TPR <14..128 CDD:223533 34/124 (27%)
TPR repeat 58..90 CDD:276809 7/31 (23%)
Atrophin-1 <1030..1308 CDD:331285 37/284 (13%)
RanBD1_RanBP2_insect-like 1324..1442 CDD:269992 57/138 (41%)
RanBD2_RanBP2_insect-like 1620..1737 CDD:269993 50/116 (43%)
RanBP2-type Zn finger 1774..1793 CDD:275376 0/18 (0%)
Nucleoporin_FG2 1806..>1986 CDD:330420 32/189 (17%)
RanBP2-type Zn finger 1833..1861 CDD:275375 4/27 (15%)
zf-RanBP 1891..1917 CDD:279035 3/25 (12%)
RanBP2-type Zn finger 1894..1913 CDD:275376 3/18 (17%)
RanBD3_RanBP2_insect-like 2034..2148 CDD:269994 22/115 (19%)
RanBD4_RanBP2_insect-like 2571..2694 CDD:269995
RGPD1XP_016859592.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 138 1.000 Domainoid score I4839
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 524 1.000 Inparanoid score I1253
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D111047at33208
OrthoFinder 1 1.000 - - FOG0000925
OrthoInspector 1 1.000 - - otm40852
orthoMCL 1 0.900 - - OOG6_104909
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3834
SonicParanoid 1 1.000 - - X2180
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.900

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