DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup358 and Ranbp1

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	NP_001101794.1	Gene:	Ranbp1 / 360739	RGDID:	1310521	Length:	203	Species:	Rattus norvegicus

Alignment Length:	192	Identity:	69/192 - (35%)
Similarity:	105/192 - (54%)	Gaps:	26/192 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1999 AAK---EDEDNDSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRL-NESD--- 2056
            |||   ||.|..::..||..::..|.|::.||:: ::||.|||||.|:..:|||:|. :|:|
  Rat     3 AAKDSHEDHDTSTENAEESNHDPQFEPIVSLPEQ-EIKTLEEDEEELFKMRAKLFRFASENDLPE 66

  Fly  2057 WKERGLGDVKILRHRQTKKLRVVMRREQVFKICLNHVLNENVVYREK--TETSWMFAVH-DFSEG 2118
            |||||.||||:|:|::...:|::|||::..|||.||.:...:..:..  ::.:|::..| ||::.
  Rat    67 WKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADE 131

  Fly  2119 ESVLERFTLRFKNKEVAQGFMEAIKNALNETAKPIEDSPVVGSVSQSTEANKPSQKNDGAAK 2180
            ....|...:||.|.|.||.|    |....|..|.||:           ...|...|||.|.|
  Rat   132 CPKPELLAIRFLNAENAQKF----KTKFEECRKEIEE-----------REKKGPGKNDNAEK 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	46/120 (38%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
Ranbp1	NP_001101794.1	RanBD_RanBP1	24..160	CDD:270000	52/140 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000925
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740