DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup358 and nup61

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	NP_587937.2	Gene:	nup61 / 2539348	PomBaseID:	SPCC18B5.07c	Length:	549	Species:	Schizosaccharomyces pombe

Alignment Length:	687	Identity:	144/687 - (20%)
Similarity:	227/687 - (33%)	Gaps:	223/687 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1086 KPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAGTVNPPATTA-VPPPV 1149
            :|...:.:||.|..    ..|.|:.:|.|      |...           |...||.|| ....:
pombe    49 RPTSGVSSPGIFAN----LAAKPVSLPAS------TTQF-----------TFGKPAVTANNDSDI 92

  Fly  1150 H----------IPQVAPSVPAQPPAPAPVSVPSMFNR------ALNNQPVEKEPPANVVITSSDP 1198
            |          |..|..||...|..    ::..:|:.      ::..:|.|::|.:|.|::..:|
pombe    93 HLKKRGLNKSFIDAVIKSVDNNPFG----NLSPLFDEYRQHFSSIEKKPAEEQPTSNAVVSEVNP 153

  Fly  1199 LPKPTTASVQPTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQP----SVSGVGSLSFNFGSKSSES 1259
            ..:.:..|   :..||     .||:..:..::......|..|    |...:|| ||.|.|.:...
pombe   154 QQQKSQDS---SSFVT-----EKPASSEKEDKEKPLVPPGAPRFGFSAPALGS-SFQFNSSAFTP 209

  Fly  1260 PFSFKTQVAKAAAEKQKEQEEAEQNQ----SGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEV 1320
            ..||.   .|:|.|.:.:::|...||    :.||..|:
pombe   210 KGSFG---EKSATEAEAKEKETSSNQTATGTAATTTNQ--------------------------- 244

  Fly  1321 EVRTGEEGEDIKFTSRAKLFRYVDKEWKERGTGVIKILCDKATGVSRVLMRR-DQTHKVCANHTI 1384
                      ..|.:.|..|.:..|| .|....:..:.....|..|....:. .|||
pombe   245 ----------FSFNTAANPFAFAKKE-NEESKPLTPVFSFSTTMASADASKETKQTH-------- 290

  Fly  1385 TADITINVANQDKDKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASEAAKSKETV 1449
                      :.||.||                            ||     :|.|...||:..|
pombe   291 ----------ETKDSKS----------------------------EE-----SKPSNNEKSENAV 312

  Fly  1450 KPTV-NTAEKGSTATAPAAFKSFVTSTPAANSLINKPQEQTKTQPNPD--PPATAAKSL-FGTLS 1510
            :|.. ||.....|...|..|     .||........|....|...:.|  ||:.||... |||.:
pombe   313 EPAKGNTMSFSWTPDKPIKF-----DTPEKKFTFTNPLSSKKLPASSDVKPPSAAAVGFSFGTTT 372

  Fly  1511 ---VSAAPATSAPASATPFASFSFTPNGSSGFGTSTASPFGNLSFGTASAVGSGNNTTLFTTALI 1572
               ..|||.:|.|.|:||                              ::||:..:
pombe   373 NPFSFAAPKSSFPTSSTP------------------------------ASVGAEKS--------- 398

  Fly  1573 KDNTVQGKTLQQESQLNKSNSSDAEEEYVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLR 1637
             :.|..|...:||.:.|.::.:.:.:..|....              .||||||.:||.|||:.|
pombe   399 -EETSNGNKSEQEEKENGNDETRSNDSLVSGKG--------------KGEENEDSVFETRAKIYR 448

  Fly  1638 WDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTWG 1702
            :|..:..:.:.|:|.:|:..|| |....|:|.|.|...||..|.||..:.:::.|......|...
pombe   449 FDATSKSYSDIGIGPLKINVDR-DTGSARILARVEGSGKLLLNVRLCQDFEYSLAGKKDVKVPAA 512

  Fly  1703 AQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQS 1739
            :.|....|    :..:|.|.....::.|..:.:.:.|
pombe   513 STDGKSIE----MYLIRVKEPSTAEKLLAELNEKKVS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285	52/246 (21%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	19/118 (16%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	35/116 (30%)
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
nup61	NP_587937.2	NUP50	3..63	CDD:286055	4/17 (24%)
nup61	NP_587937.2	RanBD_NUP50	431..543	CDD:269991	35/116 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910