DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup358 and Ranbp2

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	NP_035370.2	Gene:	Ranbp2 / 19386	MGIID:	894323	Length:	3053	Species:	Mus musculus

Alignment Length:	3356	Identity:	765/3356 - (22%)
Similarity:	1223/3356 - (36%)	Gaps:	1134/3356 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTTRKEVDAHVHKMLGKLQPGRERDIKGLAVARLYMKVQEYPKAIEYLNGYLRVRD-DAVGHNM 64
            |..::.:|:.::..:.|.....||:.:||...|:||.:.:||..|.:|::.|:.|:: |...|..
Mouse     1 MRRSKADVERYIASVQGSAPSPREKSMKGFYFAKLYYEAKEYDLAKKYISTYINVQERDPKAHRF 65

  Fly    65 IATCYSRLNPPDVTEALQHYQRSIQIDPRQSEVVIDACELLVKENNASITE-CARYWLDQANSLD 128
            :...|.  ...::.:|::.|:||::::|.|.::|:...|||.|.:   :|: .|:||:::|..|
Mouse    66 LGLLYE--VEENIDKAVECYKRSVELNPTQKDLVLKIAELLCKND---VTDGRAKYWVERAAKL- 124

  Fly   129 LSGNKQVFNLRMRVNLADSNGERDDTSGGDGEQNTLEILMYKELQARPQDVNIRIQLLRSYVEKM 193
            ..|:..::.|:.:  |.|..||       || .|.|..|:..||.|||.|:::.|:|:..|....
Mouse   125 FPGSPAIYKLKEQ--LLDCKGE-------DG-WNKLFDLIQSELYARPDDIHVNIRLVELYRSNK 179

  Fly   194 KIDQAF--------NYALKTELESKNCTSQSNEWYEQIWMVLFKIEMAKDVKKNWR--------- 241
            ::..|.        |.||::.||...|..|:.:.|      |..::.....|..||
Mouse   180 RLKDAVAHCHEADRNTALRSSLEWNLCVVQTLKEY------LESLQCLDSDKSTWRATNKDLLLA 238

  Fly   242 FWHFALHTLD-RLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQACIDHFTG 305
            :.:..|.||. |.||   ||..|.:|      .|..|....:|:  .|:    |...|......|
Mouse   239 YANLMLLTLSTRDVQ---EGRELLES------FDSALQSVKSSV--GGN----DELSATFLETKG 288

  Fly   306 QLLLHAVTLIFKREVLANKN--KWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAEQKQLIQ 368
            ...:|..:|:.|   :..::  :|.:....|....|:.:||.
Mouse   289 HFYMHVGSLLLK---MGQQSDIQWRALSELAALCYLVAFQVP----------------------- 327

  Fly   369 MWRPQGAFRCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEELLASAHQQC 433
              ||:......:.|:.||              |....|....||:.:..|....::.|....:..
Mouse   328 --RPKVKLIKGEAGQNLL--------------ETMAHDRLSQSGHMLLNLSRGKQDFLKEVVESF 376

  Fly   434 LDKSWRSQIYQQLFTHAEHKLKD-TSSHLVRNLRLQLPLFEWPNLAHIENYELQALVLPPHSLAQ 497
            .:||.:|.:...||:....|.:. ..:..:.||..|:|  :..:||   .|:..|:.....|| |
Mouse   377 ANKSGQSALCDALFSSQSSKERSFLGNDDIGNLDGQVP--DPDDLA---RYDTGAVRAHNGSL-Q 435

  Fly   498 HVYLALGTDPNKLGDAPRVVFYEGFQRDVKQNLNYCGQ----------DSISQVDVDLYL----Y 548
            |: ..||...|.|...|.:      ::.:||..::..|          :||..:|::::|    |
Mouse   436 HL-TWLGLQWNSLSTLPAI------RKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVIY 493

  Fly   549 ATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWWDLVVRLNSNQLIT 613
            .:.:|.:.|.......|            :|..:|.. :..||....|..|||.|..|...:.:
Mouse   494 TSHLQLKEKCNSHHTSY------------QPLCLPLP-VCRQLCTERQKTWWDAVCTLIHRKAL- 544

  Fly   614 EGNRAEQRAQLQHGLEAVRG--VNGPKADAII-----IFQLGKILNSRSDRSSLEARIDTLYRQG 671
            .|..|:.|..:|..:.::||  .:|.:...::     :.:.|..|||..|:.....|....:|:.
Mouse   545 PGTSAKLRLLVQREINSLRGQEKHGLQPALLVHWAQSLQKTGSSLNSFYDQREYIGRSVHYWRKV 609

  Fly   672 FSILR--HQHNQQMESYVRVFKYGSAGSTAAWQDLQSLAEEAVTYFSEKMFRIGQYEQ------- 727
            ..:|:  .:.|...|....:||:..:      .|:|:         ||    ||:||:
Mouse   610 LPLLKMIRKKNSIPEPIDPLFKHFHS------VDIQA---------SE----IGEYEEDAHITFA 655

  Fly   728 FLDEVRGLHLPMAYFLQSEACHHLEESSKLPRTSRDRYSERRRECLQKTQKLIKNDDKH-PLIAA 791
            .||.|.|               ::|::                   ....:.|||...: .|...
Mouse   656 ILDAVNG---------------NIEDA-------------------MTAFESIKNVVSYWNLALI 686

  Fly   792 MHRHQQDRNSRGIDNSFGSPDVHNNSSAYEDAEDDFYSHAAFSANRSRRQLEVTPVTPIVMAQPS 856
            .||..:|     |:|...||:.......|.....|:.......::.:...::..|| |:
Mouse   687 FHRKAED-----IENDALSPEEQEECKNYLRKTRDYLIRILDDSDSNTSVVQKLPV-PL------ 739

  Fly   857 QEMEQAVKQISKSLCVLKDDVSVG--------MEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTP 913
                ::||::..|:....:|.|.|        ..:...::|..|...|.......|....|..||
Mouse   740 ----ESVKEMLNSVMQELEDYSEGGTLYKNGCWRSADSELKHSTPSPTKYSLSPSKSYKYSPKTP 800

  Fly   914 TRDVDPAAALGLDDLFIIEDALAEHQQQQQHQQQQSHNQGAIH--PVVP---NPYTSGF-----Y 968
            .|..:...:|    |.:|...:...:::.|..:..|:|..:.|  |..|   :|...|:     :
Mouse   801 PRWAEDQNSL----LKMICQQVEAIKKEMQELKLNSNNSASPHRWPAEPYGQDPAPDGYQGSQTF 861

  Fly   969 NGMPNT-------------PSAQERFLQGPYGS------PMFNQNQMYNYYAAQAQAQAQAQFLR 1014
            :|.|.|             |:...::|..|..:      |::..|::    ..|....|.:|.:.
Mouse   862 HGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRL----PPQQHIYAYSQQMH 922

  Fly  1015 TPPAPGS---IPPPNMFGPRNPNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAP 1076
            |||...|   :....|:||       |..|..|....::|..|...|:.....|..||
Mouse   923 TPPVQSSSACMFSQEMYGP-------PLRFESPATGILSPRGDDYFNYNVQQTSTNPP------- 973

  Fly  1077 PAPLNILESKPVVALPTPGFFNTTTPVFGASPIQVPQSKPLTVPTVPIPSTAPAPPIAG-TVNPP 1140
                          ||.||:|  |.|     |:....|:......:....:....|:.| .:.||
Mouse   974 --------------LPEPGYF--TKP-----PLVAHASRSAESKVIEFGKSNFVQPMQGEVIRPP 1017

  Fly  1141 ATTAVPPPVHIPQ-------------------VAPSVPAQPPAPAPVSVPSMFNRALNNQPVEKE 1186
            .||    |.|..|                   .:|.|.||||:.|..:..|:..
Mouse  1018 LTT----PAHTTQPTPFKFNSNFKSNDGDFTFSSPQVVAQPPSTAYSNSESLLG----------- 1067

  Fly  1187 PPANVVITSSDPLPKPTTASVQPTLSVTIPAQHIKPSLVQAPEQPAQSAQPAQPSVSGVGSLS-- 1249
                 ::||..||.....:.::|                                :||..|.|
Mouse  1068 -----LLTSDKPLQGDGYSGLKP--------------------------------ISGQASGSRN 1095

  Fly  1250 -FNFGSKS------------------SESPFSF----KTQVAKAAAEKQKEQEEAEQNQSGATDP 1291
             |:||||:                  |:..|:|    |:....||:|.        .|:|..||.
Mouse  1096 TFSFGSKNTLTENMGPNQQKNFGFHRSDDMFAFHGPGKSVFTTAASEL--------ANKSHETDG 1152

  Fly  1292 NKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRY--VDKEWKERGTGV 1354
            .     ....|:.|..|.|:|::||||::||:||||.|:..|.:||||||:  ..|||||||.|.
Mouse  1153 G-----SAHGDEEDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDGESKEWKERGIGN 1212

  Fly  1355 IKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERF 1419
            :|||..|.:|..|:||||:|..|:||||.|:.|:.: ..|...| :|.:|.|.|:|||....|:.
Mouse  1213 VKILRHKTSGKIRLLMRREQVLKICANHYISPDMKL-TPNAGSD-RSFVWHALDYADELPKPEQL 1275

  Fly  1420 LVRFKT----------------------------------------------------GELAEEF 1432
            .:||||                                                    |.|..||
Mouse  1276 AIRFKTPEEAALFKCKFEEAQNILKALGTNTSTAPNHTLRIVKESATQDNKDICKADGGNLNFEF 1340

  Fly  1433 RV-------------AFTKASEAAK-----------SKETVKPTV------------NTAEKGST 1461
            ::             :|..|:.|.|           :||.:.|.:            |..::.:|
Mouse  1341 QIVKKEGPYWNCNSCSFKNAATAKKCVSCQNTNPTSNKELLGPPLVENGFAPKTGLENAQDRFAT 1405

  Fly  1462 ATA----------------PAAFKSFV-TSTPAANSLI--------------------------- 1482
            .||                |...:... .:|.:|:|.:
Mouse  1406 MTANKEGHWDCSVCLVRNEPTVSRCIACQNTKSASSFVQTSFKFGQGDLPKSVDSDFRSVFSKKE 1470

  Fly  1483 ----------------------NKPQEQTK-------------------TQPNPDPP--ATAAKS 1504
                                  ..|.:|.|                   ...||..|  :||..|
Mouse  1471 GQWECSVCLVRNERSAKKCVACENPGKQFKEWHCSLCSVKNEAHAIKCVACNNPVTPSLSTAPPS 1535

  Fly  1505 L-FGTLSVS---------------------------AAPAT------------------SAPASA 1523
            . |||..:|                           .|.||                  |||||:
Mouse  1536 FKFGTSEMSKPFRIGFEGMFAKKEGQWDCSLCFVRNEASATHCIACQYPNKQNQPTSCVSAPASS 1600

  Fly  1524 ----TPFASF--------------------------------------------SFT------PN 1534
                :|.:.|                                            :||      .|
Mouse  1601 ETSRSPKSGFEGLFPKKEGEWECAVCSVQNESSSLKCVACEASKPTHKPHEAPSAFTVGSKSQSN 1665

  Fly  1535 GSSG--FGTSTAS----------------PFGNL------------------------------- 1550
            .|:|  .||...|                .||::
Mouse  1666 ESAGSQVGTEFKSNFPEKNFKVGISEQKFKFGHVDQEKTPSFAFQGGSNTEFKSIKDGFSFCIPV 1730

  Fly  1551 -----SFG------------------------------TASAVGSGNNTTLFTTA-LIKDNTVQG 1579
                 .||                              ..|.|..|..::.||.| |.|..:.:|
Mouse  1731 SADGFKFGIQEKGNQEKKSEKHLENDPSFQAHDTSGQKNGSGVVFGQTSSTFTFADLAKSTSREG 1795

  Fly  1580 ------------------KTLQQES--QLNKSN-SSDAEE-------EYVPTAQFVPVIALPDIV 1616
                              |....:|  ...|:| |||.|:       |......|.||:.:|:.|
Mouse  1796 FQFGKKDPNFKGFSGAGEKLFSSQSGKVAEKANTSSDLEKDDDAYKTEDSDDIHFEPVVQMPEKV 1860

  Fly  1617 EVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQ 1681
            |:|||||:|.||:..|.||.|:|.|.::||||||||:|:|::..: .|:|:|||||||.|:|.|.
Mouse  1861 ELVTGEEDEKVLYSQRVKLFRFDAEISQWKERGLGNLKILKNEVN-GKLRMLMRREQVLKVCANH 1924

  Fly  1682 RLLPETKFTYATNCKAAVTWGAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKK 1746
            .:.........:....|..|.|.|:||.:.....||.:||:.::.::|.:..::.|:.:.:.|.
Mouse  1925 WITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEECQRLLLDIPL- 1988

  Fly  1747 EEVPSAAGEKEKPIKGFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQG 1811
             :.|....:..:..|....|.:.|:|..:.:...||   ||:                 ...|:.
Mouse  1989 -QTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTN---DQV-----------------KVTDEE 2032

  Fly  1812 NALNLTTSSSNKFSFGFASSATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGK 1876
            ||               :|.|..|:...      |..|:.|       ..:.|      ||.:..
Mouse  2033 NA---------------SSGADAPSASD------TTAKQNP-------DNTGP------ALEWDN 2063

  Fly  1877 SSMTSGFGDAFKPAVGSWSCSACYVNNPGESLYCSACDAPKNDTVPQKEKSLGSGLNLPPTSKFS 1941
            ..:..   ||...:|.|.|..|                               |.|...|..|..
Mouse  2064 YDLRE---DALDDSVSSSSVHA-------------------------------SPLASSPVRKNL 2094

  Fly  1942 FGFGAAAAGDKDQAGDGATFNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDN 2006
            |.||.:..|          ||| :..:|::|:.|              |.:...:..:...||::
Mouse  2095 FRFGESTTG----------FNF-SFKSALSPSKS--------------PAKLNQSGASVGTDEES 2134

  Fly  2007 DSQEVEEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYRLNE--SDWKERGLGDVKILR 2069
            |..: |||.:..||.||:||||.::|.:|||:|::::.|:|||||.::  ..|||||:||:|||:
Mouse  2135 DVTQ-EEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQ 2198

  Fly  2070 HRQTKKLRVVMRREQVFKICLNHVLNENVVYR--EKTETSWMFAVHDFSEGESVLERFTLRFKNK 2132
            :...|::|:||||:||.|:|.||.:..::..:  :.||..|::...||::||..:|...:|||.:
Mouse  2199 NYDNKQVRIVMRRDQVLKLCANHRITPDMTLQTMKGTERVWVWTACDFADGERKIEHLAVRFKLQ 2263

  Fly  2133 EVAQGFMEAIKNALNETAKPIEDSPVVGSVSQ-STEANKPSQK----------NDGAAKSRGGES 2186
            :||..|.:....|  :||:. :||.:...||. ||....|..|          .:....::|  .
Mouse  2264 DVADSFKKIFDEA--KTAQE-KDSLITPHVSHLSTPRESPCGKIAIAVLEETTRERTDLTQG--D 2323

  Fly  2187 EVLD----VGKTSSVRPTTHEVI--PP-------------------------------------- 2207
            ||:|    .|:|||...||.:.:  ||
Mouse  2324 EVIDTTSEAGETSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFGFSFN 2388

  Fly  2208 -------LPMTLPLLTLPQPLAKPNDYQTPATILFKGSS---------LSRNNSSASEASKTPSS 2256
                   ..||..:.:..:...||:..:.|.....|.||         .|:.|||.|...|||..
Mouse  2389 APLKNSNSEMTSRVQSGSEGKVKPDKCELPQNSDIKQSSDGKVKNLSAFSKENSSTSYTFKTPEK 2453

  Fly  2257 AFIFGSTDKSEPGK-----------DAGPLANLQKLASGEGQGNVLGSIF-----RSGSSNENSS 2305
            |     .:||:|..           :..|....:.||    :..:|.|.|     |.|..:|...
Mouse  2454 A-----QEKSKPEDLPSDNDILIVYELTPTPEQKALA----EKLLLPSTFFCYKNRPGYVSEEEE 2509

  Fly  2306 DG----------SVKFFFGGGNKAAEQQKKDSSE----------SVFGGNKADSQSPATQEAPKL 2350
            |.          :.|.:.....|..|:...|:.:          :|....|||     |.:.|..
Mouse  2510 DDEDYEMAVKKLNGKLYLDDSEKPLEENLADNDKECVIVWEKKPTVEERAKAD-----TLKLPPT 2569

  Fly  2351 AFGGIAAPV---FGDANPFGG--HKV-NLQKSDGKEEPKSI----IGGTPLLFGGSNAFGIPKIE 2405
            .|.|:.:..   .|:...|..  .|| ..|||..::....:    ||.|.:    :|..|....|
Mouse  2570 FFCGVCSDTDEDNGNGEDFQSELRKVCEAQKSQNEKVTDRVGIEHIGETEV----TNPVGCKSEE 2630

  Fly  2406 TQSPAKDFVFGSAPAFGQMATFSFTAAKNEKEKDITSNNTTDLK--AEGKEKKELVPETTSTFAD 2468
            ..|..|.  ..|:|..|.|          :|..|:::...||::  ::|:.|..|       |..
Mouse  2631 PDSDTKH--SSSSPVSGTM----------DKPVDLSTRKETDMEFPSKGENKPVL-------FGF 2676

  Fly  2469 LAKTGSTFADLASNPGGTFADLANKTGNDFANLSANSQGTTVGFNKSAGGGFYNLTHQNAFKNFE 2533
            .:.||.:||||||:..|.||..:......:||..|...||
Mouse  2677 GSGTGLSFADLASSNSGDFAFGSKDKNFQWANTGAAVFGT------------------------- 2716

  Fly  2534 SPQATEECDDDGDATTDD---NYDPHYDAIVELPDEIVVTTGEENETKLFGERAKLYRYDAESKQ 2595
              |.|.:..:|.|.:.:|   |.|.|::.||.|| |:.|.:|||:|..||.|||||||:|.:..|
Mouse  2717 --QTTSKGGEDEDGSDEDVVHNEDIHFEPIVSLP-EVEVKSGEEDEEVLFKERAKLYRWDRDVSQ 2778

  Fly  2596 WKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGYNYAVDA 2660
            |||||:|:||:|.|...:.:|::||::|:.|:..|..|:.::::..:|....:.:|...:|| |.
Mouse  2779 WKERGIGDIKILWHTMKKYYRILMRRDQVFKVCANHVITKAMELKPLNVSNNALVWTASDYA-DG 2842

  Fly  2661 EGKVDTEGVLERLACRFAKEEIASEFLNTVNSCIKRAKALQ 2701
            |.||      |:||.||..:|:...|......|.:....||
Mouse  2843 EAKV------EQLAVRFKTKEMTESFKKKFEECQQNIIKLQ 2877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533	33/115 (29%)
		TPR repeat	58..90	CDD:276809	7/31 (23%)
		Atrophin-1	<1030..1308	CDD:331285	63/322 (20%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	58/184 (32%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	46/116 (40%)
		RanBP2-type Zn finger	1774..1793	CDD:275376	4/18 (22%)
		Nucleoporin_FG2	1806..>1986	CDD:330420	32/179 (18%)
		RanBP2-type Zn finger	1833..1861	CDD:275375	4/27 (15%)
		zf-RanBP	1891..1917	CDD:279035	4/25 (16%)
		RanBP2-type Zn finger	1894..1913	CDD:275376	2/18 (11%)
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	47/117 (40%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995	47/122 (39%)
Ranbp2	NP_035370.2	TPR 1	26..59		11/32 (34%)
		TPR_11	59..126	CDD:290150	20/72 (28%)
		TPR repeat	59..89	CDD:276809	7/31 (23%)
		TPR 2	60..93		7/34 (21%)
		TPR_1	60..92	CDD:278916	6/33 (18%)
		TPR 3	94..128		11/37 (30%)
		TPR 4	165..201		7/35 (20%)
		TPR 5	288..319		6/33 (18%)
		TPR 6	583..616		8/32 (25%)
		TPR 7	648..681		8/66 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..802		7/28 (25%)
		RCR	<839..925	CDD:304939	17/89 (19%)
		20 X 2 AA repeats of F-G. /evidence=ECO:0000305	1000..3035		507/2139 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1171		8/28 (29%)
		RanBD1_RanBP2-like	1180..1296	CDD:270203	52/117 (44%)
		zf-RanBP	1345..1374	CDD:279035	4/28 (14%)
		RanBP2-type Zn finger	1350..1369	CDD:275375	4/18 (22%)
		zf-RanBP	1410..1438	CDD:279035	2/27 (7%)
		RanBP2-type Zn finger	1414..1433	CDD:275375	1/18 (6%)
		zf-RanBP	1469..1498	CDD:279035	1/28 (4%)
		RanBP2-type Zn finger	1473..1492	CDD:275375	0/18 (0%)
		zf-RanBP	1499..1524	CDD:279035	1/24 (4%)
		RanBP2-type Zn finger	1502..1521	CDD:275375	0/18 (0%)
		zf-RanBP	1558..1587	CDD:279035	3/28 (11%)
		RanBP2-type Zn finger	1562..1581	CDD:275375	3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1587..1609		6/21 (29%)
		zf-RanBP	1617..1645	CDD:279035	0/27 (0%)
		RanBP2-type Zn finger	1621..1640	CDD:275375	0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1648..1675		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1772		0/27 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1819..1846		8/26 (31%)
		RanBD2_RanBP2-like	1864..1980	CDD:269998	46/116 (40%)
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:P49792	1984..2124		43/254 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2060		11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2111..2144		10/47 (21%)
		RanBD3_RanBP2-like	2161..2277	CDD:270204	47/117 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2316..2348		10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2394..2430		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2443..2463		9/24 (38%)
		IR1-M	2468..2529	CDD:288995	11/64 (17%)
		Interaction with sumoylated RANGAP1. /evidence=ECO:0000250	2468..2472		0/3 (0%)
		2 X 50 AA approximate repeats	2470..2596		25/134 (19%)
		Required for E3 SUMO-ligase activity. /evidence=ECO:0000250	2470..2545		14/78 (18%)
		Interaction with UBE2I. /evidence=ECO:0000250	2470..2522		10/55 (18%)
		Interaction with SUMO1. /evidence=ECO:0000250	2523..2596		15/77 (19%)
		IR1-M	2544..2602	CDD:288995	14/62 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2598..2666		19/83 (23%)
		RanBD4_RanBP2-like	2754..2870	CDD:269999	47/122 (39%)
		cyclophilin_ABH_like	2893..3051	CDD:238907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5398
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46755
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000925
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104909
Panther	1	1.100	-	-	LDO	PTHR23138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3834
SonicParanoid	1	1.000	-	-		X2180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.810