DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup358 and Ranbp1

DIOPT Version :9

Sequence 1:	NP_001247302.1	Gene:	Nup358 / 43041	FlyBaseID:	FBgn0039302	Length:	2718	Species:	Drosophila melanogaster
Sequence 2:	NP_035369.2	Gene:	Ranbp1 / 19385	MGIID:	96269	Length:	203	Species:	Mus musculus

Alignment Length:	172	Identity:	71/172 - (41%)
Similarity:	98/172 - (56%)	Gaps:	16/172 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1298 DTS---ADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFTSRAKLFRYVDK----EWKERGTGVI 1355
            |||   ||:.:..|.|:||:.||:: |::|.||.|:..|..||||||:..:    ||||||||.:
Mouse    12 DTSTENADESNHDPQFEPIVSLPEQ-EIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDV 75

  Fly  1356 KILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAAN---DFADEQVTLE 1417
            |:|..|..|..|:|||||:|.|:||||.||..:.:. .|...|:   .|..|   |||||....|
Mouse    76 KLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELK-PNAGSDR---AWVWNTHADFADECPKPE 136

  Fly  1418 RFLVRFKTGELAEEFRVAFTKASEAAKSKETVKPTVN-TAEK 1458
            ...:||...|.|::|:..|.:..:..:.:|...|..| .|||
Mouse   137 LLAIRFLNAENAQKFKTKFEECRKEIEEREKKGPGKNDNAEK 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285	5/12 (42%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	53/124 (43%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993
		RanBP2-type Zn finger	1774..1793	CDD:275376
		Nucleoporin_FG2	1806..>1986	CDD:330420
		RanBP2-type Zn finger	1833..1861	CDD:275375
		zf-RanBP	1891..1917	CDD:279035
		RanBP2-type Zn finger	1894..1913	CDD:275376
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
Ranbp1	NP_035369.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		9/20 (45%)
		RanBD_RanBP1	24..160	CDD:270000	60/140 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..203		6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849655
Domainoid	1	1.000	105	1.000	Domainoid score	I6633
eggNOG	1	0.900	-	-		E1_COG5171
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.664386	Normalized mean entropy	S1079
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000925
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3834
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720