Protein Alignment Nup358 and npp-9

DIOPT Version :9

• Sequence 1: NP_001247302.1
• Gene: Nup358 / 43041
• FlyBaseID: FBgn0039302
• Length: 2718
• Species: Drosophila melanogaster
• Sequence 2: NP_001370159.1
• Gene: npp-9 / 175443
• WormBaseID: WBGene00003795
• Length: 884
• Species: Caenorhabditis elegans
• Alignment Length: 987
• Identity: 269/987 - (27%)
• Similarity: 402/987 - (40%)
• Gaps: 255/987 - (25%)

  Fly  1305 DPRPDFKPII-PLPDEVEVRTGEEGEDIKFTSRAKLFRYVDKEWKERGTGVIKI----------- 1357
            |.:|:...|: .:.|..::.|      ::|.|   |.:.:|....|..|||.::
 Worm     3 DQKPNMGRIVASVVDVQQLMT------MQFDS---LIKSMDSLKIEHQTGVTQLRDDIRRSEDRF 58

  Fly  1358 ---LCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDKDKKSLLWAANDFADEQVTLERF 1419
               |.|.:|...:.|   ::.|::.  ||:.|        :|.:....:........:|    :.
 Worm    59 QKQLSDLSTNHGKEL---ERLHQII--HTLLA--------RDANPLGSMIPPQQLQQQQ----QM 106

  Fly  1420 LVRFKTGELAEEFRVAFTKASEA-----------AKSKETVKPT-VNTAEKGSTATAP-AAFKSF 1471
            |:      |..:..:|..:|::|           |:::..|... :|.|:.....|.| .|..:.
 Worm   107 LI------LQRQMEMAHVQAAQAQAHAHAQAQAQAQAQSQVMANLLNAAKPAIPVTQPLVATTAQ 165

  Fly  1472 VTSTPAANSLINKPQEQTKTQPNPDPPATAAKSLFGTLSVSAAPATSAPASATPFASFSFTPNGS 1536
            ..||..|:.:|     ..||.| |:.....||..|.|    ..||. .|..||...||..|...:
 Worm   166 AKSTVPASGVI-----APKTSP-PEVVIPPAKPTFST----PTPAV-VPKPATTGFSFGGTNPAT 219

  Fly  1537 SGFG--TSTASPFGNLSFGTASAVGSGNNTTLFTTALIKDNTVQGKTLQQESQLNKSNSSDAEEE 1599
            |.||  ..||||                    ......||:                ...:.:|:
 Worm   220 SIFGKKPETASP--------------------VVVPAAKDD----------------EDEEHDED 248

  Fly  1600 YVPTAQFVPVIALPDIVEVVTGEENEDVLFEHRAKLLRWDKEANEWKERGLGNMKLLRDRTDPNK 1664
            |.|..:|.|||.|||:|||.||||.|..:|.:|:||..:..|..||||||.|.:|:|.:: |...
 Worm   249 YEPEGEFKPVIPLPDLVEVKTGEEGEQTMFCNRSKLYIYANETKEWKERGTGELKVLYNK-DKKS 312

  Fly  1665 VRLLMRREQVH------------------------KLCCNQRLLPETKFTYATNCKAAVTWGAQD 1705
            .|::|||:||.                        |:|.|..:|.........:.:.|.||..:|
 Worm   313 WRVVMRRDQVTISEETLPSNIENGTEELCWNIQVLKVCANFPILGSMTIQQMKSNEKAYTWFCED 377

  Fly  1706 YSDEELTTALLAVRFKSQDICQQFLEAVQKA------QQSIGNEPKKEEVPSAAGEKE------- 1757
            :|:::.....|:.||.:.||..:|....:||      ..:.|....||..|:|..:||
 Worm   378 FSEDQPAHVKLSARFANVDIAGEFKTLFEKAVAEAKSSSNAGKTIDKEIKPAAEVKKEVKQEVVI 442

  Fly  1758 ----KPIK-GFGDAFKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLT 1817
                ||.: ||||.||||.|||.|..||.....|::.|..|...||.:|  |:..:....::...
 Worm   443 PSNNKPEETGFGDQFKPKPGSWECPGCYVTCKADEIECACCGTSKDGSV--KEKNIFSKPSILQP 505

  Fly  1818 TSSSNKFSFGFASSATL-----------------PATGGFSFGGATQPK---------------- 1849
            ...:.|.:|||.:||..                 |:|....|||.| ||
 Worm   506 APGTPKVTFGFGASAPAKEPLAQTSQFGGSLSGSPSTSSSIFGGGT-PKGTSVFGGGAANTPTFS 569

  Fly  1850 -EKPAVAV-----------VTASASAPTSVQTAALGFGKSSMTSGFGDAFKPAVGSWSCSACYVN 1902
             .|||.||           ..||.::|.:..|.    |.|....|.......|..:.:.|..:..
 Worm   570 FNKPAAAVNATTPSFNFNNPAASTASPATSTTP----GNSLFGGGLSKTESTASSTTTPSFMFAK 630

  Fly  1903 NPGESLYCSACDAPK-----------NDTVPQKEKSLGSGLNLPPTSKFSFGF---GAA-AAGDK 1952
            | .||.:      ||           :.|.|.|::.  :..:..|.|.|..||   ||. ||...
 Worm   631 N-SESAF------PKPTFSFGKQQTPSTTAPAKQEE--NKQSETPKSVFGSGFTSGGATFAALSA 686

  Fly  1953 DQAGDGATFNFAAMP------AAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDNDSQEV 2011
            :.|..|:.|:.|.:.      ||....:..||.:.|.:.|         ::|:...||.|:..:
 Worm   687 NSAKSGSIFDAANVKKAQEELAAQKKASIFGSKNTTLNTT---------SATSHDGDETNEDGD- 741

  Fly  2012 EEEENNTYFSPVIPLPDKIDVKTGEEDEELLYVHKAKLYR----LNESDWKERGLGDVKILRHRQ 2072
            .|.|....|.|||||||.::|||||||||:::..:.|||:    |.|:  |||||||:|:|:...
 Worm   742 GEYEPEVEFKPVIPLPDLVEVKTGEEDEEVMFSARCKLYKYYSDLKEN--KERGLGDIKLLKSND 804

  Fly  2073 TKKLRVVMRREQVFKICLNHVLNENVVYREKTE--TSWMFAVHDFSEGESVLER--FTLRFKNKE 2133
             .|.|:|||||||.|:|.|..:.:::....|..  ....|...||||..|..:.  ||.:||::.
 Worm   805 -NKYRIVMRREQVHKLCANFRIEKSMKLSPKPNLPNVLTFMCQDFSEDASNADPAIFTAKFKDEA 868

  Fly  2134 VAQGFMEAIKNA 2145
            .|..|..|:::|
 Worm   869 TAGAFKTAVQDA 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	TPR	<14..128	CDD:223533
		TPR repeat	58..90	CDD:276809
		Atrophin-1	<1030..1308	CDD:331285	1/2 (50%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	23/131 (18%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	43/146 (29%)
		RanBP2-type Zn finger	1774..1793	CDD:275376	6/18 (33%)
		Nucleoporin_FG2	1806..>1986	CDD:330420	54/245 (22%)
		RanBP2-type Zn finger	1833..1861	CDD:275375	14/72 (19%)
		zf-RanBP	1891..1917	CDD:279035	4/25 (16%)
		RanBP2-type Zn finger	1894..1913	CDD:275376	4/18 (22%)
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	48/120 (40%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995
npp-9	NP_001370159.1	Herpes_BLLF1	<147..>233	CDD:282904	32/116 (28%)
		RanBD	255..408	CDD:197549	51/153 (33%)
		ZnF_RBZ	462..486	CDD:197784	9/23 (39%)
		RanBP2-type Zn finger	464..483	CDD:275376	6/18 (33%)
		Nucleoporin_FG2	547..>723	CDD:406391	45/189 (24%)
		RanBD	750..880	CDD:197549	57/132 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166879
Domainoid	1	1.000	92	1.000	Domainoid score	I4829
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111047at33208
OrthoFinder	1	1.000	-	-		FOG0000925
OrthoInspector	1	1.000	-	-		oto18330
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3834
SonicParanoid	1	1.000	-	-		X2180
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980