Protein Alignment Nup358 and ranbp2

DIOPT Version :10

• Sequence 1: NP_001247302.1
• Gene: Nup358 / 43041
• FlyBaseID: FBgn0039302
• Length: 2718
• Species: Drosophila melanogaster
• Sequence 2: XP_073768430.1
• Gene: ranbp2 / 100317326
• ZFINID: ZDB-GENE-081104-93
• Length: 2746
• Species: Danio rerio
• Alignment Length: 3105
• Identity: 690/3105 - (22%)
• Similarity: 1048/3105 - (33%)
• Gaps: 1187/3105 - (38%)

  Fly   240 WRFWH-------FALHTLDRLVQLSLEGSGLADSSKQLFRLDQYLFKFSTSIERSGDAPQRDLHQ 297
            |.|.|       .||:|.|.|.::.||
Zfish    13 WSFDHALQTLKNTALNTQDELAEVFLE-------------------------------------- 39

  Fly   298 ACIDHFTGQLLLHAVTLIFKREVLANKNKWMSTLRSALPLLLLGYQVRPIDDSSTNQWIKHCDAE 362
                 ...||.|.|.||:.|| ....:.:|.:....|....|:.||..
Zfish    40 -----MRAQLYLSAGTLLLKR-AEQRELQWRAVQDLAALCYLVAYQAP----------------- 81

  Fly   363 QKQLIQMWRPQGAF--RCAQLGRTLLGCLDRSQMEIKNDRENAEFDENKNSGNSMPGLFADSEEL 425
                    ||:|..  ..|..|...|.|.:|                ..::|:.:..|.|:.|:|
Zfish    82 --------RPRGRLLQGDAAPGPLQLLCCER----------------QSHAGHMLLNLHAEPEQL 122

  Fly   426 LASAHQQCLDKSWRSQIYQQLFTHAEHK----LKD----TSSHLVRNLRLQLPLFEWPNLAHIEN 482
            |.:..:...::|...::...||..|:|:    ..|    ||.|         |    |:..|:..
Zfish   123 LENLLENFGNRSVPVRLLDTLFNTADHQHTFLCSDHTHITSPH---------P----PSAQHLAQ 174

  Fly   483 YELQALVLPPHSLAQHVYLALGTDPNKLGDA------------PRVVFYEGFQRDVKQNLNYCGQ 535
            .:...:......|.|.|:|||..   :|.:.            ||:..       ....|:....
Zfish   175 VDRGCVQQCAGDLQQLVWLALQW---RLMEQTVDLQQWLKLLFPRLPL-------ETSKLDTSAP 229

  Fly   536 DSISQVDVDLYLYATTIQTRRKLQIQREVYDSSNLGNRNAAARPHMMPFANLVGQLGAPEQSNWW 600
            :|:..:|:::::.........:|| :.|...|:          |..:|.. |:..|....|..||
Zfish   230 ESLCLLDLEVFVSGVVFTCEAQLQ-ECECVSSA----------PRCLPLP-LMKLLSTARQREWW 282

  Fly   601 DLVVRLNSNQLITEGNRAEQRAQLQHGLEAVRGVN-------------------GPKADA----- 641
            |.|..| .::....|:.|:.|..:||||..:||..                   |.:.::
Zfish   283 DAVYNL-IHKRAQPGSSAKLRMVVQHGLGMLRGAEKHGLQPALLVHWARHLAAAGERTNSYYEQR 346

  Fly   642 -----------IIIFQLGKILNSRSDRSSLEARIDTLYRQGFSILRHQHNQQMESYVRVFKYGSA 695
                       :::..|.||.|.||....||..        |...|.:..|..|  |...:...:
Zfish   347 DYAGRSVHYWKLLLPLLEKICNKRSIPEPLEPL--------FPHFRSRDIQAAE--VCALQQEVS 401

  Fly   696 GSTAAWQDLQSLAEEAVTYFSEKMFRIGQ-------YEQFLDEV-RGLH----------LPMAYF 742
            .|.|...|::...|||:... |::..:|.       |::.::|. .||.          |....:
Zfish   402 LSAAVLLDIEGSTEEAIAQL-EQINTVGSDWQLAKIYQRLVEEAGNGLEETQGRCTNFLLQFQKY 465

  Fly   743 LQSEACHHLEESSKLPRTSRDRYSERRRECLQKTQKLIKNDDKHPLIAAMHRHQQDRNSRGIDNS 807
            |........|:..:|| ...:...:..:|..|:.::........|......|...........::
Zfish   466 LMKICQASTEDMERLP-VGMEEVLDLLKEVSQQLEEDGVEQQVEPQQVEFPRTSSPGRPAEAQHA 529

  Fly   808 FGSPDVHNNSSAYEDAEDDFYSHAAFSANRSRRQLEVTPVTPIVMAQPSQEMEQAVKQISKSLCV 872
            .|:|                 |.|..||:.:||. ..:|.||     |....:|  |.:.:.||
Zfish   530 LGTP-----------------SPAKSSASPARRP-TFSPKTP-----PHWAEDQ--KSLLQMLC- 568

  Fly   873 LKDDVSVGMEAMRQDIKVLTEKFTGLEDLLKKIKISSRDTPTRDVDPAAALGLDDLFIIEDALAE 937
                  ..:||::.::          .||
Zfish   569 ------QQVEALKNEV----------HDL------------------------------------ 581

  Fly   938 HQQQQQHQQQQSHNQGAIHPVVPNPYTSGF-----YNGMPNTPSAQERFLQGPYG----SPMFN- 992
                   :|..:.:.|:.:.:.|. .|.||     ::|:|.|.|.     .||.|    ||.:|
Zfish   582 -------RQNPADSTGSSYRIYPE-NTEGFPAAQTFHGVPLTVST-----TGPSGYYSQSPAYNS 633

  Fly   993 -------------------------QNQMYNYYAAQAQAQAQAQFLRTPPAPGSIPPPNMFGPRN 1032
                                     |..||:|          .|...|||...:  |..|: |:.
Zfish   634 QYLLRPAANVTPTKGPVYGMNRLPPQQHMYSY----------QQQTHTPPLQST--PACMY-PQE 685

  Fly  1033 PNFGLPSMFPPPTVPSVAPYIDAMGNFTQPPPSLIPPPAQPAAPPAPLNILESKPVVALPTPGFF 1097
            ..||.|..|..|....::||.:.....:.|.|::.|                     .||.||:|
Zfish   686 QVFGAPIRFESPATSLLSPYSEEYYAHSVPQPTVNP---------------------TLPEPGYF 729

  Fly  1098 NTTTPVFGASPIQVPQSK--------PLTVPTVPIPSTAPAPPIAGTVNPPATTAVPPPVHIPQV 1154
            ..........|.:..:||        |...|.|     :..|...|.:..|:|:.
Zfish   730 TKPNAAASMQPSRSSESKTEARTSLGPQFTPEV-----SKVPHFGGVIVAPSTST---------- 779

  Fly  1155 APSVPAQPPAPAPVSVPSMFNRALNNQPVEKEPPANVVITSSDPLPKPTTASVQPTLSVTIPAQH 1219
                       ...|....||...      |....:...:||.   :..:.|:...|:..||.:
Zfish   780 -----------TTTSTAFKFNSNF------KSNDGDFTFSSSQ---RKNSESLLGLLTSDIPPK- 823

  Fly  1220 IKPSLVQAPEQPAQSAQPAQPSVSGVGS-----LSFNFGSKS------SESPFSFKTQVAK---- 1269
                 ...|.:|.||.:  |..|...||     .||..||:|      :..|||| |..||
Zfish   824 -----TDGPSEPKQSHE--QTGVFTFGSKNATGFSFTDGSQSKMNIFGNTDPFSF-TSGAKPVLG 880

  Fly  1270 AAAEKQKEQEEAEQNQSGATDPNKTLPQDTSADDYDPRPDFKPIIPLPDEVEVRTGEEGEDIKFT 1334
            ||.||           ||.:|.:     .|..::.:..|.|:||:||||:|:|:||||.|:..|.
Zfish   881 AAEEK-----------SGDSDND-----STHVEEDEDGPHFEPIVPLPDKVDVKTGEEEEEEMFC 929

  Fly  1335 SRAKLFRY-VD-KEWKERGTGVIKILCDKATGVSRVLMRRDQTHKVCANHTITADITINVANQDK 1397
            .||||||: .| |||||||.|.||||..|.:|..|:||||:|..|:||||.||||:.:. .|...
Zfish   930 KRAKLFRFDADTKEWKERGIGSIKILKHKTSGKVRLLMRREQVLKICANHYITADMALK-PNAGS 993

  Fly  1398 DKKSLLWAANDFADEQVTLERFLVRFKTGELAEEFRVAFTKASE--------AAKSKETVKPTVN 1454
            | ||.:|.|.|:|||....|:..:||||.:.|..|:|.|.:|.:        ..|:.|.:||.:.
Zfish   994 D-KSWVWYAMDYADEMPKTEQLAIRFKTADDAALFKVKFEEAQKFISAQGPLLEKTSELLKPPIA 1057

  Fly  1455 TAE----------------------------------------KGSTA----------------- 1462
            :.|                                        ||..|
Zfish  1058 SKESDLKIRFSKKEGEWDCETCCVRNAPASAVCVACGSPAPSAKGKPAEQIKSSALPKPLVASKE 1122

  Fly  1463 ----------------------TAPAAFKSFVTSTPAANSLINKPQEQTKTQPNPDP-------- 1497
                                  .:||:......|:||. |...||.||.|:..:..|
Zfish  1123 SELKIRFSKKDGEWDCETCCVRNSPASVACVACSSPAP-SAKGKPAEQIKSSVSLAPPAKVFSFG 1186

  Fly  1498 -PATAAKSL---------------------FGTLSVSAAP--------ATSAPA------SATPF 1526
             ||.:|||.                     ||:.:.:..|        ..|.||      ..:|.
Zfish  1187 LPADSAKSTSFTDGSTKGSAFGSQIPASFSFGSSNAAVTPLGFASQTDKKSIPADTKQNTKVSPT 1251

  Fly  1527 ASFSFTPNGSSGFG---------------------------------TSTASPFG---------- 1548
            .:||.||...|.|.                                 |..|:.||
Zfish  1252 PAFSLTPGFGSQFAKKDGQWDCDCCLVRNDASATECVSCNTPCSTPKTGLAAMFGKKAGQWDCDA 1316

  Fly  1549 -----------------------------------NLSFGTAS----AVGSGNNTTL-----FTT 1569
                                               :.|||::|    |.|..::.|.     |.|
Zfish  1317 CLVRNEGESSHCVSCQTANPNMKSKTSSAPSSSTFSFSFGSSSSQPAATGFKSSFTAGPAFQFGT 1381

  Fly  1570 ALIKDNTVQGKTLQQESQLNKSNSS---------------------------------------- 1594
            :..|.::...|.....:|.:||:||
Zfish  1382 STEKSSSEGFKFASSSTQADKSSSSSNFSFSMPAPGEGFKFGITEPQTKASDTQPQTSSASDLLK 1446

  Fly  1595 ----------------------------------------------------------------- 1594
                                                                             
Zfish  1447 NIAELHKEKEKEAIQSSSDDSADTSAHDDNPLISGKADTFSFADLAKSSKEGFQFGQQDPSFRGF 1511

  Fly  1595 ------------------DAEEEYVPT-----AQFVPVIALPDIVEVVTGEENEDVLFEHRAKLL 1636
                              |.|:|...|     .||.||:.:||.|::|||||:|.:|:..|.||.
Zfish  1512 AGAGQQLFTVLPKPDTSADQEDEMYRTEENDDIQFEPVVQMPDKVDLVTGEEDEKILYSQRVKLF 1576

  Fly  1637 RWDKEANEWKERGLGNMKLLRDRTDPNKVRLLMRREQVHKLCCNQRLLPETKFTYATNCKAAVTW 1701
            |:|.|.::|||||:||:|||::..: .|:|:|||||||.|:|.|..:..............|..|
Zfish  1577 RFDPETSQWKERGVGNLKLLKNNQN-GKLRVLMRREQVLKVCANHWITTTMNLKPLAGSDRAWMW 1640

  Fly  1702 GAQDYSDEELTTALLAVRFKSQDICQQFLEAVQKAQQSIGNEPKKEEVPSAAGEKEKPIKGFGDA 1766
            .|.|:||.:.....||.:||:.::.::|.:..::.|:.:.:.|           .:.|.|
Zfish  1641 LASDFSDGDARLEQLAAKFKTPELAEEFKQRFEECQRLLLDIP-----------LQTPHK----- 1689

  Fly  1767 FKPKAGSWNCQACYTNNGQDQLYCLACQEPKDATVPPKQSGLDQGNALNLTTSSSNKFSFGFASS 1831
                         ..|.|:........:|.|        |||....:. ||..|..:     .||
Zfish  1690 -------------LVNTGRTAHLIQKAEEMK--------SGLKDLKSF-LTPQSKEE-----ESS 1727

  Fly  1832 ATLPATGGFSFGGATQPKEKPAVAVVTASASAPTSVQTAALGFGKSSMTSGFGDAF-KPAVGSWS 1895
            .|..:|.                :|:....|..||   .||.:....:..|...:: ||
Zfish  1728 VTADSTS----------------SVIVKLDSETTS---TALEWDNYDLREGALKSYTKP------ 1767

  Fly  1896 CSACYVNNPGESLYCSACDAP-KNDTVPQKEKSLGSGLNLPPTSKFSFGFGAAAAGDKDQAGDGA 1959
                           ||.||. :.|||   .|||             |.||.:..|
Zfish  1768 ---------------SASDASVQPDTV---AKSL-------------FRFGESTTG--------- 1792

  Fly  1960 TFNFAAMPAAVAPTTSIGSSSFTFSMTKPKPDQQQPNSTAAKEDEDNDSQEVEEEENNTYFSPVI 2024
             |:|:..|              ..|.:|......|..::...:||.:.||  |||.:..||.||:
Zfish  1793 -FSFSFQP--------------ILSPSKSPCKLNQSQASVGTDDEQDTSQ--EEERDGQYFEPVV 1840

  Fly  2025 PLPDKIDVKTGEEDEELLYVHKAKLYRLNE--SDWKERGLGDVKILRHRQTKKLRVVMRREQVFK 2087
            |:||.::|.||||||::|:.|:|||||.::  |.|||||:||:|||:|.:||::|:||||:||.|
Zfish  1841 PMPDLVEVSTGEEDEQVLFSHRAKLYRYDKTLSQWKERGIGDLKILQHYETKRVRLVMRRDQVLK 1905

  Fly  2088 ICLNHVLNENVVYR--EKTETSWMFAVHDFSEGESVLERFTLRFKNKEVAQGFMEAIKNA----- 2145
            :|.||.::.::...  :..|.:|:::..||:||:..:|:..:|||.::.|..|.:..:.|
Zfish  1906 LCANHWIDSSMKLEPMKGAEKAWIWSAFDFAEGQGKVEQLAVRFKLQDTASIFRDVFEEAKTALD 1970

  Fly  2146 ----------------------------LNETAK-----------------PIE-DSPVVGSV-- 2162
                                        |.||.|                 |.| .:||..:|
Zfish  1971 RDTLLNPRSAREASFIQESICGQAAVAVLEETTKEPSGLPEHSSPKPERTPPAEFSTPVSKTVVS 2035

  Fly  2163 -------SQSTEANKPSQKNDGA------AKSRGGESEVLDVGKTSSVRPTTHEVIPPLPMTLPL 2214
                   |.|.:....|.|.:.|      |....|||.:.....|||...|        |.:||.
Zfish  2036 PPKFVFGSDSVQKIFGSPKENSAVSPVRTADEDSGESRLKTSAVTSSQAGT--------PFSLPT 2092

  Fly  2215 LTLPQPLAKPN-----------DYQTPATILFKGSSL---------------------SRNNSSA 2247
            .:|...|.|.|           .::..|....|..|:                     :|..:..
Zfish  2093 KSLDFRLFKDNPMAFWTCTSDAQFEAQACPSLKQKSVQDLYNDDDDDDDLEVIFERQPTREQADL 2157

  Fly  2248 SEASKTPSSAFIFGSTDKSEPGKDAGPLANLQKLASGEGQGNVLGSIFRSGSSNENSSDGSVKFF 2312
            :.:...|.:.|.:    |:.||          ..:..|.......|..||........|......
Zfish  2158 AASLLLPHTFFCY----KNRPG----------YTSEEEEDDEDFESAVRSLQGQLYEDDHECVLV 2208

  Fly  2313 FGGGNKAAEQQKKD------------SSESVFGGNKADSQSPATQEAPKLAFGGIAAPVFGDANP 2365
            :.....|.|:|:..            ||:|.....:|:..|..|| |..|....:......||:.
Zfish  2209 WEKRASADEEQRARRLLLPPTFLCGVSSDSDLEPERAEDSSTHTQ-ADTLTQTQVRLDPSHDASV 2272

  Fly  2366 FGGHKVNLQKSDGKEEPKSIIGGTPLLFGGSNAFGIPKIETQSPAKDFVFGSAPAFGQMATFSFT 2430
            .....:.|||:| :..|..:
Zfish  2273 ASSSTMELQKTD-RSSPIDL--------------------------------------------- 2291

  Fly  2431 AAKNEKEKDITSNNTTDLKAEGKEKKELVPETTSTFADLAKTGSTFADLASN--PGGT------- 2486
            :.|...|... |.:|..|.........|.|...|:.||.:.|..|.||.:|:  |.||
Zfish  2292 STKRSSESSF-SADTAHLTPADPSGTVLTPTDPSSSADPSGTSLTPADPSSSAEPSGTSLTPADP 2355

  Fly  2487 --------------------FADLANKTGNDFA------NLSANSQGTTVGFNKSAGGGFYNLTH 2525
                                ||||| ||..:||      |.|.::.|..| |..:|...    ||
Zfish  2356 SSTTEPSGIFFGSATASPFSFADLA-KTSGEFAFGKKDENFSWSNAGAAV-FGAAARAE----TH 2414

  Fly  2526 QNAFKNFESPQATEECDDDGDATTDDNYDP-HYDAIVELPDEIVVTTGEENETKLFGERAKLYRY 2589
            :             :.||:||.....:.|. |::.||.|| |:.|.:|||:|..||.||.:|||:
Zfish  2415 R-------------DDDDEGDDDEAPHSDEIHFEPIVSLP-EVEVRSGEEDEEILFKERCRLYRW 2465

  Fly  2590 DAESKQWKERGVGEIKVLEHPELQTFRLIMRQEQIHKLVLNMNISASLQMDYMNAQMKSFLWAGY 2654
            |.:.:|||||||||:|:|.||:.:::||:||:||:.|:..|..||:.:.:.:||:...:.:|...
Zfish  2466 DRDLQQWKERGVGELKILFHPQKKSYRLLMRREQVLKVCANHTISSGITLTHMNSSANALVWTAT 2530

  Fly  2655 NYAVDAEGKVDTEGVLERLACRFAKEEIASEF---LNTVNSCIKRAKALQ 2701
            :|| :.:|||      |:||.:|...::|..|   ......|:.:|.:.|
Zfish  2531 DYA-EGDGKV------EQLAVKFKSADLAQSFRRVFEDCQRCVSQADSAQ 2573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup358	NP_001247302.1	LapB	<30..204	CDD:442196
		TPR repeat	58..90	CDD:276809
		PHA03247	<1030..1308	CDD:223021	64/300 (21%)
		RanBD1_RanBP2_insect-like	1324..1442	CDD:269992	62/127 (49%)
		RanBD2_RanBP2_insect-like	1620..1737	CDD:269993	45/116 (39%)
		ZnF_RBZ	1772..1796	CDD:197784	2/23 (9%)
		RanBP2-type Zn finger	1774..1793	CDD:275376	2/18 (11%)
		Nucleoporin_FG2	1806..>1985	CDD:435043	36/180 (20%)
		RanBP2-type Zn finger	1833..1861	CDD:275375	3/27 (11%)
		zf-RanBP	1891..1917	CDD:395516	4/26 (15%)
		RanBP2-type Zn finger	1894..1913	CDD:275376	1/18 (6%)
		RanBD3_RanBP2_insect-like	2034..2148	CDD:269994	52/150 (35%)
		RanBD4_RanBP2_insect-like	2571..2694	CDD:269995	49/125 (39%)
ranbp2	XP_073768430.1	None