DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sil1 and Hspbp1

DIOPT Version :9

Sequence 1:	NP_651356.1	Gene:	Sil1 / 43034	FlyBaseID:	FBgn0039296	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001347558.1	Gene:	Hspbp1 / 66245	MGIID:	1913495	Length:	357	Species:	Mus musculus

Alignment Length:	338	Identity:	71/338 - (21%)
Similarity:	128/338 - (37%)	Gaps:	52/338 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 EPLALDYKPDIIEESIRRVKEQKKSYAELRKAYKEFQKNFRTDGELIVQLIDQFRNFSR-TP--- 155
            ||   |..|:.:.|..|:..::..|.|            ||...|.:.|:.:..|..|: ||
Mouse    57 EP---DPPPEPMSEERRQWLQEAMSAA------------FRGQREEVEQMKNCLRVLSQATPAMA 106

  Fly   156 ----LESEMRSKLDCLENLEYLLHQIDNALMFIDNGGLDDVLLPIVVNDTSTSLRVSAMRVLGSL 216
                |.::.:.:...||.|..|...:|||..|....|: .:|:...:...:..||..|.:::|:.
Mouse   107 GEAELATDQQEREGALELLADLCENMDNAADFCQLSGM-HLLVGRYLEAGAAGLRWRAAQLIGTC 170

  Fly   217 ASNNPKAQIKVFEKNFGSHLAQILTSSGNVGEISAALHAFGALLRKFPLAQQRVLSTSGTQALIK 281
            :.|....|.:|........|.::|...........||.|...|:|:......:.|...|...|::
Mouse   171 SQNVAAIQEQVLGLGALRKLLRLLDRDSCDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMR 235

  Fly   282 VLQSPDVELRSKAKVVTLISDLVLEKRSVLDVSKDDPEASSTMAQYVLLDFESWLKTPGYCAAVD 346
            .:|....:|  |.|...|:.:|::          ..||...|:....::.....|....:....:
Mouse   236 AMQQQVQKL--KVKSAFLLQNLLV----------GHPEHKGTLCSMGMVQQLVALVRTEHSPFHE 288

  Fly   347 TVLTKEFLLLLEQPEVVEQFATALETTEDMCTSTWSQSSGLRHALLTVRNRYANSTDEYRLEVSQ 411
            .||.....|:.:.|:.|.:........|::          |||....::.|     :||:.|: :
Mouse   289 HVLGALCSLVTDFPQGVRECREPELGLEEL----------LRHRCQLLQQR-----EEYQEEL-E 337

  Fly   412 ILAKLCERLFNKP 424
            ...||.:..|:.|
Mouse   338 FCEKLLQTCFSSP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sil1	NP_651356.1	SIL1	167..>326	CDD:374797	36/158 (23%)
Hspbp1	NP_001347558.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		4/13 (31%)
		Fes1	43..137	CDD:369996	24/94 (26%)
		ARM 1	130..172		10/42 (24%)
		armadillo repeat	135..172	CDD:293788	8/37 (22%)
		ARM 2	175..215		8/39 (21%)
		armadillo repeat	178..213	CDD:293788	7/34 (21%)
		ARM 3	218..257		9/40 (23%)
		armadillo repeat	231..255	CDD:293788	6/25 (24%)
		ARM 4	260..299		7/38 (18%)
		armadillo repeat	263..299	CDD:293788	5/35 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R442
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840