DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sil1 and CG10973

DIOPT Version :9

Sequence 1:	NP_651356.1	Gene:	Sil1 / 43034	FlyBaseID:	FBgn0039296	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001034002.1	Gene:	CG10973 / 39447	FlyBaseID:	FBgn0036306	Length:	306	Species:	Drosophila melanogaster

Alignment Length:	275	Identity:	69/275 - (25%)
Similarity:	114/275 - (41%)	Gaps:	55/275 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 LESEMRSKLDCLENLEYL---LHQIDNALMFIDNGGLDDVLLPIVVNDTSTSLRVSAMRVLGSLA 217
            |.||..|..|.:|:|:.:   :..||||:..:..||...:|..|..:|  :.:|.||:..:..:|
  Fly    67 LNSEESSTDDQIESLDVIRSHIDDIDNAITLVKLGGTATLLRYITHSD--SEVRESALNTVAEVA 129

  Fly   218 SNNPKAQIKVFEKNFGSHLAQILTSSGNVGEISAALHAFGALLRKFPLAQQRVLSTSGTQALIKV 282
            .||...|..:....|...||:.|:.| |...:..:|:|..:|:|.|...........|.::||..
  Fly   130 QNNVFCQNALINDKFLPALAKNLSHS-NPNTVRCSLYAISSLIRNFQPGYDEFKRIKGIRSLIPC 193

  Fly   283 LQSPDVELRSKAKVVTLISDLVLEKRSVLDVSKDDPEASSTMAQYVLLDFESWLKTPGYCAAVDT 347
            |:|.:..:  ..|...||:.|...::||.|                                 |.
  Fly   194 LKSTNTNV--YVKTAFLIASLTSIEKSVRD---------------------------------DF 223

  Fly   348 VLTKEFLLLLEQPEVVEQFATALETTEDMCTSTWSQSSGLRHALLTVRNRYANSTDEYRLEVSQI 412
            |..:.|.:|:|..:.|:.|....|||. ...|:.|:.|.|:   |:...|     :|...::.||
  Fly   224 VKEEVFPVLVENLKPVDDFDIKQETTL-FALSSLSRESELK---LSTEKR-----EEILSKLQQI 279

  Fly   413 LAK-----LCERLFN 422
            ::|     .||.:.|
  Fly   280 ISKNKQSETCEDMVN 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sil1	NP_651356.1	SIL1	167..>326	CDD:374797	41/161 (25%)
CG10973	NP_001034002.1	Fes1	13..94	CDD:285773	9/26 (35%)
		ARM	<92..172	CDD:237987	24/82 (29%)
		armadillo repeat	97..128	CDD:293788	8/32 (25%)
		HEAT_2	<104..171	CDD:290374	18/69 (26%)
		armadillo repeat	136..172	CDD:293788	10/36 (28%)
		ARM	138..258	CDD:237987	34/156 (22%)
		armadillo repeat	178..209	CDD:293788	6/32 (19%)
		HEAT repeat	227..257	CDD:293787	9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R442
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870