DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb19

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_444374.2	Gene:	Pcdhb19 / 93890	MGIID:	2136757	Length:	801	Species:	Mus musculus

Alignment Length:	736	Identity:	180/736 - (24%)
Similarity:	284/736 - (38%)	Gaps:	194/736 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SRCYLEGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNA------------PV 81
            |:.:.|.|    .....|::..|:::|.|         ..|:.|.:.|.:|            |:
Mouse    24 SQAHSEAG----RLSVVEEMLSGALVGNL---------VKDLGLQVDELSAREAQVASSDNKLPL 75

  Fly    82 EIHPGTKELALSVELDKEGVRG---PSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIG 143
            :::..|.:|.||..||:|.:.|   |..::..|:.     .:|..::...::|||||||:|.::.
Mouse    76 QLNINTGDLLLSEPLDREELCGSTEPCVLHFQVLL-----KNPLKILQAELQVTDVNDNSPVFLE 135

  Fly   144 TPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEG----TLVLK 204
            ....|.:.|.:..|...|..: |.|.| .|..:...|::....:......:|| :|    .|||.
Mouse   136 KEMVLEIPENSPVGAVFLLES-AIDLD-VGINAVKSYEISQNSHFHVTMRVNP-DGRKYPELVLD 197

  Fly   205 KALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRM 269
            ||||||:.....:.|.|.|.|||||....|:||.:.|.:|.:|:|....|...:|.:...|.|.:
Mouse   198 KALDYEEQHELRLILTALDGGTPPRSGTALVRVEVIDINDNSPEFDHMFYEVTVPENSMLGSLLI 262

  Fly   270 RPEPLKAVDQDEGICAPIQYTIVQSQD--AKYFRIHPHNGAISLLTPIGYAD--VANGATLVVKA 330
               ...|.|.|.||...:.|....:.:  .|.|.|:.|:|.|.|.   ||.|  .....::::||
Mouse   263 ---TASAWDLDSGINGEVSYAFSHASEDIRKTFAINEHSGEIRLK---GYLDFETTESYSIIIKA 321

  Fly   331 T-------------QI----DN-------------PDRYALTTVQL----------------TRP 349
            |             |:    ||             |:..|.|.|.:                |.|
Mouse   322 TDRGGLFGKSTVRIQVMDVNDNFPEIIVSSFISPIPENTAETLVMIFSIRDKDSGENGKMVCTIP 386

  Fly   350 G----------------------------------SHSDLST--------------------LAF 360
            .                                  |.:||.|                    .||
Mouse   387 EGLPFVLKSSIENYYHLETDGALDRESIAEYNITISVTDLGTPRLTTQHTIIVQVADINDNAPAF 451

  Fly   361 VQKRFVMRIREDTAVGNRI--LALPTNKPGK--HLKYVIPDPVNSQFFSVGSL-------GELVL 414
            .|..:.|...|:.:....|  ::...:..|.  |:.|.:....:.| .::.||       |:|..
Mouse   452 TQTSYTMFFHENNSPALHIGTISATDSDAGSNAHITYSLMSAQDLQ-MALSSLISINADNGQLFA 515

  Fly   415 AKPLDYEKMTKHEFQVLATD---GMTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRAD 476
            .:.||||.:...||||.|||   ...:|.|.:.:.|:|.||..|...........|.:.|..||
Mouse   516 LRALDYEVLQAFEFQVGATDRGSPALSSQALVRVVVLDDNDNAPFVLYPMQNASAPCTELLPRA- 579

  Fly   477 SFEGVLIGKVEAADGDRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LIAI 537
            :..|.|:.||.|.|.|......||   |:....|||.: ...|..:|..:|.|..::..| |:.:
Mouse   580 AEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSV-WAHNGEVRTTRLLSERDAPKHRLLLL 643

  Fly   538 ATDTGVPPRSTSVPVSV-TMEGLT--------LARSGWNSN------MLGMFGMIMGLFL---MI 584
            ..|.|.||||.||.:.| .::|.:        :||:..:..      ::.....:..|||   |:
Mouse   644 VKDNGDPPRSASVTLHVLVVDGFSQPYLPLPEVARNPAHEEDALTLYLVTALASVSSLFLLSVML 708

  Fly   585 IVALSCYIVRSKKQGKSASSG 605
            .|.     ||..::.::||.|
Mouse   709 FVG-----VRLCRRARAASLG 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/105 (24%)
		Cadherin_repeat	145..244	CDD:206637	33/102 (32%)
		Cadherin_repeat	253..347	CDD:206637	30/143 (21%)
		Cadherin_repeat	365..452	CDD:206637	26/100 (26%)
		Cadherin_repeat	461..555	CDD:206637	32/98 (33%)
Pcdhb19	NP_444374.2	Cadherin_2	32..112	CDD:285466	19/93 (20%)
		Cadherin_repeat	137..238	CDD:206637	33/103 (32%)
		Cadherin_repeat	247..343	CDD:206637	24/101 (24%)
		Cadherin_repeat	356..447	CDD:206637	10/90 (11%)
		Cadherin_repeat	455..557	CDD:206637	27/102 (26%)
		Cadherin_repeat	576..664	CDD:206637	30/89 (34%)
		Cadherin_C_2	687..769	CDD:293101	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050