DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb18

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_444373.1	Gene:	Pcdhb18 / 93889	MGIID:	2136756	Length:	792	Species:	Mus musculus

Alignment Length:	779	Identity:	178/779 - (22%)
Similarity:	291/779 - (37%)	Gaps:	200/779 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILDSRCYLEGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDINL---SLREKNAPV------ 81
            :|...|.  .|.....:..||:...||.:..|         ..|:.|   :|..|...|
Mouse    19 LLGGLCL--AGSELGRYSVTEETERGSFVANL---------AKDLGLGVEALAAKRTRVVCDDNK 72

  Fly    82 -----EIHPGTKELALSVELDKEGVRGPSS---IYVNVICIRRHSTDPSFVIPVNVRVTDVNDNA 138
                 :.|.|  :|..:.:||:|.:.||:.   :|..::     ..:|..:....:|:.|:||::
Mouse    73 QHLFLDSHTG--DLLTNEKLDREKLCGPTEPCMLYFQIL-----MDNPFQIYRAELRILDINDHS 130

  Fly   139 PQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEG---- 199
            |.:......|.:.|.|..|| ..:..||:|:| .|......|.:.|..:. ::...|..||
Mouse   131 PIFQDKKMILKILENTAVGT-TFRLERAQDSD-GGRNGIQNYTISPNTFF-HITVHNSDEGMIYP 192

  Fly   200 TLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRP 264
            .|||.||||:|....|::.|.|.|.|:|||.....:.:::.|.:|..|:|.:|.|..:.|.:...
Mouse   193 ELVLDKALDWEGQPEFSLTLTALDGGSPPRSGTATIHILVLDINDNAPQFPQELYEIQAPENSPI 257

  Fly   265 GELRMRPEPLKAVDQDEGICAPIQYTIVQ-SQDAK-YFRIHPHNGAISLLTPIGY---------A 318
            |.:.::   :...|.|.|:.|.|.|:... |:|.: .|:|:|.:|.|:|...:.|         .
Mouse   258 GLVVIK---VTGEDVDSGVNAEISYSFFDASEDIRATFQINPFSGEITLKALLDYEFIKSYKLNV 319

  Fly   319 DVANGATLVVKATQI-------DNPDRYALTTVQ------------------------------- 345
            ...:|..|..:.|.:       ||.....::::.
Mouse   320 QAVDGGGLSARCTVLVRVLDVNDNAPELIMSSLVNEVVENSPETVLAVFRINDRDSGENGKMVCH 384

  Fly   346 -------LTRPG-------------------------SHSDLST--------------------L 358
                   |.:|.                         :.|||.|                    .
Mouse   385 IQENLPFLLKPSVDNFYILMTEGALDRESRAEYNITITVSDLGTPRLTTQHTIRVQVSDINDNAP 449

  Fly   359 AFVQKRFVMRIREDTAVGNRI--LALPTNKPGK--HLKYVIPDPVNSQFFSVGSL-------GEL 412
            ||.|..:.:.:||:.:....|  ::...:..|.  |:.|.:. |......::.||       |:|
Mouse   450 AFNQTSYTLFVRENNSPAMHIGTISATDSDAGSNAHITYSLL-PTQDLQMTLTSLVSINADNGQL 513

  Fly   413 VLAKPLDYEKMTKHEFQVLATDGMT---NSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSR 474
            ...|.||||.:...||.|.|||..:   :|.|.:.:.|:|.||..|...........|.:.|..|
Mouse   514 FAIKALDYEALQAFEFHVGATDRGSPELSSQALVRVVVLDDNDNAPFVLYPMQNASAPYTELLPR 578

  Fly   475 ADSFEGVLIGKVEAADGDRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LI 535
            . :..|.|:.||.|.|.|......||   |:....|||.: ...|..:|..:|.|..:...| |:
Mouse   579 T-AEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSV-WAHNGEVRTTRLLSERDVPKHRLL 641

  Fly   536 AIATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGM----------IMGLFLMIIVA--- 587
            .:..|.|.||||.||.:.|      |...|::...|.:..:          ::.|:|:|.:|
Mouse   642 LLVKDNGDPPRSASVTLQV------LLVDGFSQPYLPLPEVAHNPTQGEEDVLTLYLVIALASVS 700

  Fly   588 ----LSCYI---VRSKKQGKSASSGLGLGRNRVHSQAH------SSVSSANLVTHEKLAGNGNG 638
                ||..:   ||..::.::||.| |......|...|      :...|.|......|.|..:|
Mouse   701 SLFLLSVLLFVGVRLCRRARAASLG-GCSVPEGHFPGHLVDVSGTGTLSQNYQYEVCLMGGSSG 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	22/107 (21%)
		Cadherin_repeat	145..244	CDD:206637	32/102 (31%)
		Cadherin_repeat	253..347	CDD:206637	23/149 (15%)
		Cadherin_repeat	365..452	CDD:206637	26/100 (26%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
Pcdhb18	NP_444373.1	Cadherin_2	32..112	CDD:285466	19/95 (20%)
		Cadherin_repeat	140..238	CDD:206637	32/100 (32%)
		Cadherin_repeat	247..343	CDD:206637	21/98 (21%)
		Cadherin_repeat	355..447	CDD:206637	6/91 (7%)
		Cadherin_repeat	455..557	CDD:206637	27/102 (26%)
		Cadherin_repeat	571..664	CDD:206637	32/100 (32%)
		Cadherin_C_2	688..771	CDD:293101	19/77 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050