DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb17

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_444372.2	Gene:	Pcdhb17 / 93888	MGIID:	2136754	Length:	799	Species:	Mus musculus

Alignment Length:	797	Identity:	180/797 - (22%)
Similarity:	299/797 - (37%)	Gaps:	183/797 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GGSAE--SFLATEDLAVGSIIGKLRINGDANAETGDIN-----LSLREKNAPVEIHPGTKELALS 93
            |..||  .:...|:...||.:..|  ..|...:..:|:     :..:|....::::..:.:|.::
Mouse    25 GAGAELGPYSIEEETERGSFVANL--GKDLGVDLAEISNRRARIISQENKEHLQLNLQSGDLLIN 87

  Fly    94 VELDKEGVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGT 158
            .:||:|.:.||  |...|:..:....:|..|....:||.|:||.:|.:......|
Mouse    88 EKLDREELCGP--IEPCVLHFQVLMENPLEVFQAELRVMDINDYSPVFSEREMIL---------- 140

  Fly   159 RILQGARAEDA-------DQPGPFSTVEYQVLPGPYSEYVQFLNPLEG----TLVLKKALDYEQL 212
            |||:.:...|.       |.....:.::...|.......|...|..:|    .|||:|.||.|:.
Mouse   141 RILENSALGDTFPLNNALDSDVAINNIQTYRLSSNSHFLVVTRNRSDGRKYPELVLEKELDREEE 205

  Fly   213 QNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAV 277
            ....:.|.|.|.|.|||.....:.:.:.|.:|..||||:.:|..:||.:...|.|.:   .:.|.
Mouse   206 PELRLTLTALDGGAPPRSGTAQVLIEVVDINDNAPKFQQPTYRVQIPENSPTGSLVL---TVSAN 267

  Fly   278 DQDEGICAPIQYTIVQ-SQD-AKYFRIHPHNGAISLLTPIGYADV---------------ANGAT 325
            |.|.|....:.|.:.| |:| :|...::|..|.|.|...:.:..:               :...|
Mouse   268 DLDSGDYGKVLYALSQPSEDISKTLEVNPVTGEIRLRKEVDFETIPSYEVDIKATDGGGLSGKCT 332

  Fly   326 LVVKATQI-DN-----------------PDR---------------------------------- 338
            |::|...: ||                 ||.
Mouse   333 LLLKVVDVNDNAPEVMLSALTSPVPENSPDEVVAVFSVKDPDSANNGKMIASIEEDLPFLLKSSG 397

  Fly   339 ---YALTTVQ-LTRPGSH--------SDLST--------------------LAFVQKRFVMRIRE 371
               |.|.|.: |.|....        |||.|                    .||.|..:.:.:||
Mouse   398 KNFYTLVTKRALDREEREKYNITITVSDLGTPRLTTQHTITVQVSDTNDNAPAFNQTSYTLFVRE 462

  Fly   372 DTAVGNRI--LALPTNKPG--KHLKY-VIP--DP---VNSQFFSVGSLGELVLAKPLDYEKMTKH 426
            :.:....|  ::...:..|  .|:.| ::|  ||   ::|........|:|...:.||||.:...
Mouse   463 NNSPAMHIGTISATDSDAGSNSHISYSLLPSHDPQLALDSLISINADNGQLFALRALDYEALQAF 527

  Fly   427 EFQVLATD---GMTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEA 488
            ||.|.|.|   ...:|.|.:.:.|:|.||..|...........|.:.|..|| :..|.|:.||.|
Mouse   528 EFHVGAIDQGSPALSSQALVRVVVLDDNDNAPFVLYPMQNSSAPCTELLPRA-AEPGYLVTKVVA 591

  Fly   489 ADGDRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LIAIATDTGVPPRSTS 549
            .|.|......||   |:....|||.: ...|..:|..:|.|..:...| |:.:..|.|.||||.|
Mouse   592 VDRDSGQNAWLSFQLLKATEPGLFSV-WAHNGEVRTTRLLSERDVPKHRLVLLVKDNGDPPRSAS 655

  Fly   550 VPVSV-TMEGLT--------LARS-GWNSNMLGMF-----GMIMGLFLMIIVALSCYI-VRSKKQ 598
            |.:.| .::|.:        :||: ..:.:.|.::     ..:..|||:.::   .:: ||..::
Mouse   656 VTLHVLVVDGFSQPYLPLPEVARNPAHDEDALTLYLVIALASVSSLFLLSVL---LFVGVRLCRR 717

  Fly   599 GKSAS-SGLGLGRNRV--HSQAHSSVSSANLVTHEKLAGNGNGNGAS----VTSGGVSVLHMKHG 656
            .:||| ||..:....:  |......|.:.:......:...|:.:|.|    :.....|.|....|
Mouse   718 ARSASLSGYSVPEGHIPGHLVDVRGVGTLSQSYQYDVCLMGDSSGTSEFNFLKPVFPSSLDQCSG 782

  Fly   657 GNITMANPMNN--GLHH 671
            ..|...:.::|  |.||
Mouse   783 KEIEENSSLHNSFGFHH 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	21/95 (22%)
		Cadherin_repeat	145..244	CDD:206637	25/109 (23%)
		Cadherin_repeat	253..347	CDD:206637	28/166 (17%)
		Cadherin_repeat	365..452	CDD:206637	25/99 (25%)
		Cadherin_repeat	461..555	CDD:206637	32/98 (33%)
Pcdhb17	NP_444372.2	Cadherin_2	33..112	CDD:285466	15/82 (18%)
		Cadherin_repeat	137..238	CDD:206637	25/110 (23%)
		Cadherin_repeat	246..343	CDD:206637	21/99 (21%)
		Cadherin_repeat	356..447	CDD:206637	11/90 (12%)
		Cadherin_repeat	455..557	CDD:206637	26/101 (26%)
		Cadherin_repeat	576..664	CDD:206637	30/89 (34%)
		Cadherin_C_2	687..770	CDD:293101	16/85 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050