DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb15

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_444370.1	Gene:	Pcdhb15 / 93886	MGIID:	2136750	Length:	786	Species:	Mus musculus

Alignment Length:	564	Identity:	153/564 - (27%)
Similarity:	249/564 - (44%)	Gaps:	103/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SFLA--TEDLAVGSIIGKL-----RINGDANAETGDINLSLREKNAPVEIHPGTKELALSVELDK 98
            :|||  .:||.:|  :|:|     ||..|.|  |..:.||           |.|.||.|:.:||:
Mouse    43 TFLANLAKDLGLG--LGELSAREARIVSDQN--TRFLLLS-----------PLTGELILNEKLDR 92

  Fly    99 EGVRGPSS--IYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRIL 161
            |.:.||:.  :....:.:.|    |..:....:.:.|:|||:|.::.....|.:||.|.||..:|
Mouse    93 EELCGPTEPCVLTFQLLLER----PFQIYRAALHIKDINDNSPVFLDKEILLKISESTTPGATLL 153

  Fly   162 QGARAEDADQPGPFSTVEYQVLPGPY--------SEYVQFLNPLEGTLVLKKALDYEQLQNFTVK 218
            . .||:||| .|..|...|.:.|..|        .|     .|:...|||.|.||.|::..||:.
Mouse   154 L-ERAQDAD-VGTNSLSNYTISPNDYFHIHVHDGGE-----GPIIPELVLDKMLDREEIPEFTLT 211

  Fly   219 LRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGI 283
            |.|.|.|:|||....|:::::.|.:|.:|:|.:..|..:.|.:...|.|.:   .:.|.|.|.|.
Mouse   212 LTALDGGSPPRSGTALVQILVLDINDNSPQFVQSLYKVQSPENTPVGSLVV---AVSARDLDTGS 273

  Fly   284 CAPIQYTIVQSQD--AKYFRIHPHNGAISLLTPIGY---------------ADVANGATLVVKAT 331
            ...|.||...:.:  .:.|:|:..:|.:.|...:.|               ..::....:||:..
Mouse   274 YGQIDYTFFYATERILQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGGGLSGKCAVVVEVM 338

  Fly   332 QI-DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILALPTNKPGKHLKYVI 395
            .: |||..:.|::  |..|...:...|:..|   |.:|.|:....|..:.::..:.|     :|:
Mouse   339 DVNDNPPEFLLSS--LNSPIPENSQETVVAV---FKIRDRDSGNNGKTLCSIANDLP-----FVL 393

  Fly   396 PDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD-GMTNSTAE--LTLEVIDVNDWEPRF 457
            ...|.: |::      ||..||||.|..|::...:..|| |:...|.:  :|::|.|:||..|.|
Mouse   394 KPSVEN-FYT------LVTEKPLDRESNTEYNITITVTDMGIPRLTTQHTITVQVSDINDNAPTF 451

  Fly   458 RETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGD--RNDKLELSLRGQHAGLFEIDS------- 513
            .:|.|...|       |.::...:.||.:.|.|.|  .|..:..|||..|.....:||
Mouse   452 TQTSYTMFV-------RENNSPALHIGTISATDSDSGSNAHITYSLRLPHDPQLALDSLISINAD 509

  Fly   514 TGNIY-MRPEQLQSLNESTVHLIAIATDTGVPPRSTSVPVSVTM 556
            .|.:: :|....::|.....|:.||  |.|.|..|:...|.|.:
Mouse   510 NGQLFALRALDYEALQAFEFHVGAI--DQGSPALSSQALVRVVI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	26/97 (27%)
		Cadherin_repeat	145..244	CDD:206637	37/106 (35%)
		Cadherin_repeat	253..347	CDD:206637	22/111 (20%)
		Cadherin_repeat	365..452	CDD:206637	23/89 (26%)
		Cadherin_repeat	461..555	CDD:206637	26/103 (25%)
Pcdhb15	NP_444370.1	Cadherin_2	30..111	CDD:285466	25/82 (30%)
		Cadherin_repeat	140..238	CDD:206637	37/104 (36%)
		Cadherin_repeat	247..343	CDD:206637	18/98 (18%)
		Cadherin_repeat	356..447	CDD:206637	26/105 (25%)
		Cadherin_repeat	455..557	CDD:206637	27/106 (25%)
		Cadherin_repeat	571..664	CDD:206637
		Cadherin_C_2	686..769	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960