DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb13

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_444368.1	Gene:	Pcdhb13 / 93884	MGIID:	2136748	Length:	796	Species:	Mus musculus

Alignment Length:	781	Identity:	183/781 - (23%)
Similarity:	296/781 - (37%)	Gaps:	182/781 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 WFNKATLGAILDSRCYLEGGGSAESFLATEDLAVGSIIGK------LRINGDANAETGDINLSLR 75
            |.....:..::.|....|.|..:..:...|:...|:.:..      ||: |:..|.  |..:..:
Mouse     7 WCKTRQVMVLITSMLLWEVGSGSIQYAMLEETESGTFVANLTKHLGLRV-GELAAR--DARVVFK 68

  Fly    76 EKNAPVEIHPGTKELALSVELDKEGVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQ 140
            .....:::.|.|::|.|:..||:|.:.|  |....|:..|....:|.......:||.|:||:||:
Mouse    69 GNRQYLQLDPQTQDLMLNENLDREELCG--STEPCVLSFRVLLKNPLQFYQAELRVIDINDHAPE 131

  Fly   141 WIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEG----TL 201
            :......|.:||:..|| :|.....|:|.| .|..|...|.|...|:. :|...|..:|    .|
Mouse   132 FPAREMLLKISEIAPPG-KIFPLKMAQDLD-TGSHSIQSYTVSDNPHF-HVLTRNRSDGKKFPEL 193

  Fly   202 VLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGE 266
            ||.||||.|:.....:||.|.|.|:|||...|.:::::.|.:|..|:|.:|.|..::|.:...|.
Mouse   194 VLDKALDREKQDQLRLKLTAVDGGSPPRSGTTEIQILVLDINDNTPEFAQELYEVQVPENSPIGS 258

  Fly   267 LRMRPEPLKAVDQDEGICAPIQYTIVQSQDA-KYFRIHPHNGAISLLTPIGY-------ADV--- 320
            |.:   .:.|.|.|.|....:.|.:.|..|. :.|.|:...|.|.|.:.:.:       .||
Mouse   259 LLI---TVSARDLDAGPFGEVSYGLSQDDDVNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEAL 320

  Fly   321 -ANGAT----LVVKATQI-DNPDRYALTTVQ---------------------------------- 345
             ..|.|    |||:...: ||.....|:::.
Mouse   321 DGGGLTGKCSLVVQVLDVNDNAPEVILSSLNSPIPENLPGIIVAVFSVSDADSGNNQQVMCSIDD 385

  Fly   346 ----LTRPGSH-------------------------SDLST--------------------LAFV 361
                |.||...                         :|:.|                    .||.
Mouse   386 NLPFLLRPSMENFYTLETDGALDRESRSEYNITITVTDMGTPRLTTQHNITVQVSDINDNAPAFT 450

  Fly   362 QKRFVMRIREDTAVGNRI--LALPTNKPGK--HLKYVIPDPVNSQFFSVGSL-------GELVLA 415
            |..:.:.:.|:.:....|  ::...:..|.  |:.|.:..|.:.| .::.||       |:|...
Mouse   451 QTSYTLFVHENNSPALHIGTISATDSDSGSNAHITYSLLLPQDKQ-LTLTSLVSINADNGQLFAL 514

  Fly   416 KPLDYEKMTKHEFQVLATD-GMTNSTAELTLEVI--DVNDWEPRFRETHYEFMVPKSSLQSRADS 477
            :.||||.:...||:|.||| |....::::.:.|:  |.||..|...........|.:.|..|| :
Mouse   515 RALDYEALQAFEFRVDATDQGSPALSSQVLVRVVVLDDNDNAPFVLYPMQNASAPCTELLPRA-A 578

  Fly   478 FEGVLIGKVEAADGDRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LIAIA 538
            ..|.|:.||.|.|.|......||   .:....|||.: ...|..:|..:|.|..:...| |:.:.
Mouse   579 EPGYLVTKVVAVDRDSGQNAWLSFQLFKATEPGLFSV-WAHNGEVRTTRLLSERDVPKHRLLLLV 642

  Fly   539 TDTGVPPRSTSVPVSVTM-----------------------EGLTLARSGWNSNMLGMFGMIMGL 580
            .|.|.||||.||.:.|.:                       :.|||       .::.....:..|
Mouse   643 KDNGEPPRSASVTLHVLLVDGFSQPYLPLPEVAQDSTEDAEDALTL-------YLVIALASVSSL 700

  Fly   581 FLMIIVALSCYI-VRSKKQGKSASSGLGLGRNRVHSQAH-SSVSSANLVT----HEKLAGNGNGN 639
            ||:.:|   .:: ||..|:.::||.| |......|...| ..||.|..::    :|.......|.
Mouse   701 FLLSVV---LFVGVRLCKKFRAASLG-GYSVPEGHFPGHLVDVSGAGTLSQSYQYEVCLRGDTGT 761

  Fly   640 G 640
            |
Mouse   762 G 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	23/96 (24%)
		Cadherin_repeat	145..244	CDD:206637	35/102 (34%)
		Cadherin_repeat	253..347	CDD:206637	26/148 (18%)
		Cadherin_repeat	365..452	CDD:206637	24/100 (24%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
Pcdhb13	NP_444368.1	Cadherin_2	30..111	CDD:285466	18/85 (21%)
		Cadherin_repeat	139..237	CDD:206637	35/100 (35%)
		Cadherin_repeat	246..341	CDD:206637	23/97 (24%)
		Cadherin_repeat	354..445	CDD:206637	5/90 (6%)
		Cadherin_repeat	453..555	CDD:206637	25/102 (25%)
		Cadherin_repeat	574..662	CDD:206637	29/89 (33%)
		Cadherin_C_2	686..765	CDD:293101	22/88 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050