DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhb5

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_444360.1	Gene:	Pcdhb5 / 93876	MGIID:	2136739	Length:	792	Species:	Mus musculus

Alignment Length:	579	Identity:	143/579 - (24%)
Similarity:	231/579 - (39%)	Gaps:	133/579 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SFLA--TEDLAVGSIIGKL-----RINGD-------ANAETGDINLSLREKNAPVEIHPGTKELA 91
            ||:|  .:||.:|:  |:|     |:..|       .::||||  |.||||
Mouse    42 SFVAHLAKDLGLGA--GELAARSARVVSDHDKQQFILDSETGD--LLLREK-------------- 88

  Fly    92 LSVELDKEGVRG---PSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEV 153
                ||:|.:.|   |..::..|...:     |.......:.:.|:|||:|::......|.:.|.
Mouse    89 ----LDREELCGSVDPCVLHFQVFLEK-----PVQFFQGELLIQDINDNSPEFPDKELLLKILEN 144

  Fly   154 TVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEG----TLVLKKALDYEQLQN 214
            :.|||| .....|:|.| .|.....:|.|.|..:. :|...|..||    .||..:|||.|:...
Mouse   145 SQPGTR-FSLKLAQDLD-VGSNGLQQYTVNPNSHF-HVLTRNNSEGKKYPELVQDRALDREEQAE 206

  Fly   215 FTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAV-- 277
            .::.|.|.|.|:|||....|:|::|.|.:|..|:|....|..::.....|      ..|:..|
Mouse   207 LSLILTALDGGSPPRSGTALVRILIMDINDNAPEFVNNPYEVQVLESSPP------DSPVLTVFA 265

  Fly   278 -DQDEGICAPIQYTIVQSQD--AKYFRIHPHNGAISLLTPIGY---------ADVANGATLVVKA 330
             |.|.|....:.|.:.|:.|  .|.|.|:...|.|.|.|.:.:         .:..:|..|..|.
Mouse   266 QDADAGNFGRVSYGLFQASDEIQKTFSINEFTGEIRLKTKLDFEKTKSYHVEIEATDGGGLSGKG 330

  Fly   331 TQI-------DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILALPTNKPG 388
            :.:       ||.....::::..:.| .:|..:.:|.::    :|.|:....|..|.::     .
Mouse   331 SVVIEVLDVNDNAPELTISSLTSSVP-ENSPETVVAIIR----IRDRDSGENGKMICSI-----S 385

  Fly   389 KHLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD-GMTNSTAE--LTLEVIDV 450
            .|:.::: .|....|::      ||...|||.|...::...:..:| |....|.:  :|::|.|:
Mouse   386 DHVPFIL-KPSYKNFYT------LVTESPLDRESRAEYNITITVSDLGTPRLTTQHTITVKVSDI 443

  Fly   451 NDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGD--RNDKLELSLRGQHAGLFEIDS 513
            ||..|.|.:|.|...|       |.::...:.||.:.|.|.|  .|..:..||...|.....:.|
Mouse   444 NDNAPAFSQTSYTMFV-------RENNSPALHIGTISATDSDSGSNAHITYSLLPPHDQQLALHS 501

  Fly   514 TGNIYMRPEQLQSLNESTVHLIAI----------------ATDTGVPPRSTSVPVSVTM 556
                      |.|:|.....|.|:                |||.|.|..|:...|.|.:
Mouse   502 ----------LISINADNGQLFALSALDYEALQGFEFYVGATDRGSPELSSQALVRVVV 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/105 (24%)
		Cadherin_repeat	145..244	CDD:206637	34/102 (33%)
		Cadherin_repeat	253..347	CDD:206637	22/114 (19%)
		Cadherin_repeat	365..452	CDD:206637	19/89 (21%)
		Cadherin_repeat	461..555	CDD:206637	25/111 (23%)
Pcdhb5	NP_444360.1	Cadherin_2	29..111	CDD:285466	25/90 (28%)
		Cadherin_repeat	139..237	CDD:206637	34/100 (34%)
		Cadherin_repeat	245..342	CDD:206637	20/102 (20%)
		Cadherin_repeat	354..446	CDD:206637	23/108 (21%)
		Cadherin_repeat	454..556	CDD:206637	26/114 (23%)
		Cadherin_repeat	575..663	CDD:206637
		Cadherin_C_2	687..769	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050