DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhga2

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_291063.1	Gene:	Pcdhga2 / 93710	MGIID:	1935214	Length:	931	Species:	Mus musculus

Alignment Length:	601	Identity:	158/601 - (26%)
Similarity:	248/601 - (41%)	Gaps:	119/601 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ATLGAILDSR-----CYL-----EGGGSAESFLATEDLAVGSIIGK----LRINGDANAETGDIN 71
            |||..:..||     |.|     |.......:...|::..||.:|.    |.:...|..|.| :.
Mouse     2 ATLQKLPQSRMLVLLCALWAALWEAKAGQIRYSVPEEIDKGSFVGSIAKDLGLEPQALEERG-VR 65

  Fly    72 LSLREKNAPVEIHPGTKELALSVELDKEGV---RGPSSIYVNVICIRRHSTDPSFVIPVNVRVTD 133
            :..|.|:....::|.:..|..:..:|:|.:   ..|..:..|::.     .|...:..|.|.|||
Mouse    66 IVSRGKSQLFALNPRSGSLVTAGRIDREELCAQSTPCLVNFNLLL-----EDKLTIYSVEVEVTD 125

  Fly   134 VNDNAPQWIGTPYTLTLSEVTVPGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY---------- 187
            ||||||::......|.:||.|.||.|| |:.  |.||| .|..:..:|::....:
Mouse   126 VNDNAPRFGVEDPELKISETTTPGFRIPLKS--AHDAD-VGENTLQKYKLNSNDHFSLDVRTGAD 187

  Fly   188 -SEYVQFLNPLEGTLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQR 251
             ::|.:        |||::|||.|:.....:.|.|.|.|.|.|.....:||.:.||:|..|.|.:
Mouse   188 GNKYPE--------LVLERALDREEEAVHHLVLVASDGGNPVRSGTCRIRVKVLDANDNAPAFTQ 244

  Fly   252 ESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQD----AKYFRIHPHNGAISLL 312
            ..|...:|.:...|   .|...:.|.|.|||..|  |.|..|..|    ...|.:...:|.|::.
Mouse   245 AEYRVRVPENTPVG---TRILTVTATDADEGYNA--QVTYFQEHDPGETTDAFELKSTSGDITIT 304

  Fly   313 TPIGY---------ADVANGATLVVKATQI-------DNPDRYALTTVQLTRPGSHSDLSTLAFV 361
            ..:.|         .:..:|..|:.:...|       ||...:.:|:...:.| ..:.|.|:.
Mouse   305 KSLDYEKAKFHEIDIEAQDGPGLLTRTKVIVTVLDVNDNAPEFYMTSATASVP-EDAPLGTVI-- 366

  Fly   362 QKRFVMRIREDTAVGNRIL--ALPTNKPGKHLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMT 424
               .:..:.:..:..|.::  :||...|.|..:            ||.|...||..:.||.|:.:
Mouse   367 ---ALFNVHDRDSGQNAVVTCSLPEMLPFKLER------------SVDSYYRLVTTRALDREQFS 416

  Fly   425 KHEFQVLATDG---MTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKV 486
            .:...|.|.||   ..::.|.|.|:|.|:||..|.|....|...:|:::.:       |..|..|
Mouse   417 FYNITVSAKDGGSPSLSTDAHLLLQVADINDNPPSFPRRVYSAYIPENNPR-------GTSIFSV 474

  Fly   487 EAADGDRNDK-------LELSLRGQHAGLF-EIDS-TGNIY-MRP---EQLQSLNESTVHLIAIA 538
            .|:|.|.||.       .|.|.:|.....: .|:| ||.:| :|.   ||.|.|     .|..||
Mouse   475 LASDPDSNDNAHVTYSLAEDSFQGAPLSSYVSINSDTGVLYALRSFDYEQFQDL-----QLWVIA 534

  Fly   539 TDTGVPPRSTSVPVSV 554
            .|:|.||.|::|.:|:
Mouse   535 ADSGNPPLSSNVSLSL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	24/97 (25%)
		Cadherin_repeat	145..244	CDD:206637	33/110 (30%)
		Cadherin_repeat	253..347	CDD:206637	24/113 (21%)
		Cadherin_repeat	365..452	CDD:206637	22/91 (24%)
		Cadherin_repeat	461..555	CDD:206637	33/107 (31%)
Pcdhga2	NP_291063.1	Cadherin_2	30..112	CDD:285466	16/87 (18%)
		Cadherin_repeat	139..238	CDD:206637	33/109 (30%)
		Cadherin_repeat	246..343	CDD:206637	21/101 (21%)
		Cadherin_repeat	353..448	CDD:206637	26/112 (23%)
		Cadherin_repeat	456..558	CDD:206637	33/107 (31%)
		Cadherin_repeat	579..666	CDD:206637
		Cadherin_C_2	688..772	CDD:293101
		Cadherin_tail	808..>904	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050