DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Pcdhga1

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_291062.1	Gene:	Pcdhga1 / 93709	MGIID:	1935212	Length:	931	Species:	Mus musculus

Alignment Length:	894	Identity:	213/894 - (23%)
Similarity:	349/894 - (39%)	Gaps:	199/894 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LEGGGSAESFLATEDLAVGSIIGKLRINGDANAETGD-----INLSLREKNAPVEIHPGTKELAL 92
            ||.|.....:...|:...||.:|.  |..|...||.:     |.:..|.::....::|.:..|..
Mouse    24 LEAGAGNIRYSVPEETDKGSFVGS--IAKDLGLETRELMERGIRIVSRGRSQLFSLNPRSGSLVT 86

  Fly    93 SVELDKEGV---RGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVT 154
            :..:|:|.:   ..|..:..|::     ..|...::|:.|.:.|:|||.||:......|.:||:|
Mouse    87 AGRIDREELCAQSTPCVVSFNIL-----MEDEMKLLPIEVEIIDINDNTPQFQLEELELKMSEIT 146

  Fly   155 VPGTRILQGARAEDADQPGPFSTVEYQVLPGP-YSEYVQF--LNPLEGTLVLKKALDYEQLQNFT 216
            .||||| .....:|.| .|..|...||:...| :|..||.  ..|.:..:||::.||.|:.....
Mouse   147 TPGTRI-PLPLGQDLD-VGINSLQSYQLSANPHFSLDVQQGPEGPQQPEMVLQRPLDREKDAVHY 209

  Fly   217 VKLRAQDQGTPPRHSDTL-LRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQD 280
            :.|.|.|.|: |.||.|| :.|.:.|.:|..|.|.:..|...:|.:...|...::   :.|.|.|
Mouse   210 LVLTASDGGS-PIHSGTLQIHVQVVDVNDNPPAFTKAEYHVSVPENVPLGTRLLK---VNATDPD 270

  Fly   281 EGICAPIQYTI--VQSQDAKYFRIHPHNGAISLLTPIGYAD---------VANGATLVVKATQI- 333
            ||....:.|:.  |.....:.|::..:.|.:|...|:.:.:         ..:||.|:.:|..:
Mouse   271 EGANGRVTYSFHKVDHSVVRKFQLDAYTGELSNKEPLDFEEYKVYPMEIQAQDGAGLMARAKVLV 335

  Fly   334 ------DNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNRIL--ALPTNKPGKH 390
                  ||.....:|:|..|.|.:....:|:|.:.      :.:..|..|..:  ::|.|.|.|.
Mouse   336 TVLDVNDNAPEVGITSVTNTVPENFPPGTTIALIS------VHDQDADNNGHITCSIPGNLPFKL 394

  Fly   391 LKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMT---NSTAELTLEVIDVND 452
            .|.|      ..::      .||..:.||.|:.::|...:.|||..|   ::.|.::|.|.|:||
Mouse   395 EKLV------DNYY------RLVTERTLDREQSSRHNITITATDQGTPPLSTQAHISLLVTDIND 447

  Fly   453 WEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDK-------LELSLRG-QHAGLF 509
            ..|.|.:..|...:|:::.:       |..|..|:|.|.|.|:.       :|.:::| ..:..|
Mouse   448 NPPVFEQDSYSVYIPENNPR-------GASIFSVKAQDADHNENALVTYALVEDTIQGVPLSSYF 505

  Fly   510 EIDS-TGNIYMRPEQLQSLNES---TVHLIAIATDTGVPPRSTSVPVSVTM--------EGL--T 560
            .|:| ||.:|    .|||.:..   .:.|..:|.|:|.|..|::|.:|:.|        |.|  .
Mouse   506 SINSDTGVVY----ALQSFDYEQFRDLQLRVMAHDSGNPQLSSNVSLSLFMIDQNDNAPEILYPV 566

  Fly   561 LARSGWNSNMLGMFGMIMGLFLMIIVA----------LSCYIVRSKKQGKSASSGLGLGRNR--- 612
            |...|.....|.......|..:..:||          ||..::::.:.| ..|.||..|..|
Mouse   567 LPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNSWLSYRLLKASEPG-LFSVGLHTGEVRTAR 630

  Fly   613 -------------VHSQAHSSVSSANLVTH---------EKLAGNGN-GNGASVTSGGVS----- 649
                         |..|.|.....:..||.         :.||..|: |..|......::
Mouse   631 ALLERDALKQSLVVAVQDHGQPPLSTTVTFTIAVADSIPDLLADLGSMGTPADPQDSDLTLYLVV 695

  Fly   650 -----------------VLHMKHGGNITMANPMNNGLHHVASGASSSMALGSSAALLE---RERE 694
                             ||.::|..:..:.....|||  ....||:.:.:....|.|:   ||..
Mouse   696 AVAVVSCIFLAFVIVLLVLKLRHWYSSRLLQTEANGL--TGLPASNFVGVDGVHAFLQTYSREIS 758

  Fly   695 RERDRERQ-----RESYAATVRIFLPGIVSRASANGQLF-------EEDEIEHDSLQTENNN--- 744
            ...|..:.     :.:||.|       ::|..|...|.|       .||:.|..|.|...|.
Mouse   759 LTADSRKSHLIFPQPNYADT-------LISHESCEKQEFLSAPQSLLEDKEEIFSQQAPPNTDWR 816

  Fly   745 ----RKVAATGVASGGVTTISTTPANAGSN-------LLSATDAM-GSS 781
                ::...:|..:|..|  .|.|.|....       |.||::|. |||
Mouse   817 FSQAQRPGTSGSQNGDET--GTWPNNQFDTEMLQAMILASASEAADGSS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	21/98 (21%)
		Cadherin_repeat	145..244	CDD:206637	36/102 (35%)
		Cadherin_repeat	253..347	CDD:206637	22/111 (20%)
		Cadherin_repeat	365..452	CDD:206637	22/91 (24%)
		Cadherin_repeat	461..555	CDD:206637	28/105 (27%)
Pcdhga1	NP_291062.1	Cadherin_2	31..112	CDD:285466	16/87 (18%)
		Cadherin_repeat	137..238	CDD:206637	36/103 (35%)
		Cadherin_repeat	246..343	CDD:206637	18/99 (18%)
		Cadherin_repeat	355..448	CDD:206637	27/110 (25%)
		Cadherin_repeat	456..558	CDD:206637	29/112 (26%)
		Cadherin_repeat	579..666	CDD:206637	16/87 (18%)
		Cadherin_C_2	688..772	CDD:293101	13/85 (15%)
		Cadherin_tail	808..>904	CDD:292596	15/58 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050