DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdhgc3

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_291059.1	Gene:	Pcdhgc3 / 93706	MGIID:	1935201	Length:	934	Species:	Mus musculus

Alignment Length:	932	Identity:	212/932 - (22%)
Similarity:	333/932 - (35%)	Gaps:	272/932 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILDSRCYLEGGGSAESFLATEDLAVGSIIG-KLRINGDANAETGDINLSLREKNAPVEIHPGTKE 89
            ||:.|   |.|....:.:....|.:||:.. :||:...|:....::|..             |.|
Mouse    37 ILEER---ERGFPVGNVVTDLGLDLGSLSARRLRVVSGASRRFFEVNWE-------------TGE 85

  Fly    90 LALSVELDKEGVRG--PSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSE 152
            :.::..||:|.:.|  ||......:.:.    :|..:....|.|.|:|||.|.:......|.:||
Mouse    86 MFVNDRLDREELCGTLPSCTVTLELVVE----NPLELFSAEVVVQDINDNNPSFPTGEMKLEISE 146

  Fly   153 VTVPGTRI-LQGARAEDADQPGPFSTVEYQVLPGPYSEY--VQFLNPLEGT----LVLKKALDYE 210
            ...||||. |:.|...|.   |..|...|::   .::||  ::.....:||    |||::|||:|
Mouse   147 ALAPGTRFPLESAHDPDV---GSNSLQTYEL---SHNEYFALRVQTREDGTKYAELVLERALDWE 205

  Fly   211 QLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLK 275
            :..:..:.|.|.|.|||.|.:...:|:.:.||:|..|.|.:..|.|.:..|..||   .|...:.
Mouse   206 REPSVQLVLTALDGGTPARSATLPIRITVLDANDNAPAFNQSLYRARVREDAPPG---TRVAQVL 267

  Fly   276 AVDQDEGICAPIQYTI--------------------------VQSQDAKYFRIH----------- 303
            |.|.|||:...|.|:.                          :..:|.|...|:
Mouse   268 ATDLDEGLNGEIVYSFGSHNRAGVRELFALDLVTGVLTIKGRLDFEDTKLHEIYIQAKDKGANPE 332

  Fly   304 -------------------------------------------------PHNGAISLLTPIGY-- 317
                                                             ..||.::...|.|.
Mouse   333 GAHCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPF 397

  Fly   318 ---ADVANGATLVVKA--------------TQIDN--PDRYALTTVQL------TRPGSHSDLST 357
               :.:.|..||...|              |..|:  |...|||||::      ..|...|
Mouse   398 SLTSSLKNYFTLKTSAALDRETMPEYNLSITARDSGIPSLSALTTVKVQVSDINDNPPQSS---- 458

  Fly   358 LAFVQKRFVMRIREDTAVGNRILAL----PTNKPGKHLKYVIPDP-----VNSQFFSVG-SLGEL 412
                |..:.:.:.|:...|..||.|    |...|...|.:.:.:|     :.|::|::. ..|.|
Mouse   459 ----QSSYDVYVEENNLPGVPILNLSVWDPDAPPNARLSFFLLEPGAETGLVSRYFTINRDNGVL 519

  Fly   413 VLAKPLDYEKMTKHEFQVLA--TDGMTNSTA---ELTLEVIDVND-----WEPRFRETHYEFMVP 467
            ....|||||  .:.|||:.|  .||.|...|   .:.:.|.|.||     ..||..::..| |:|
Mouse   520 TTLVPLDYE--DQREFQLTAHINDGGTPVLATNISVNVFVTDRNDNAPQVLYPRPGQSSVE-MLP 581

  Fly   468 KSSLQSRADSFEGVLIGKVEA--ADGDRNDKLELSLRG-QHAGLFEID-STGNI-YMRPEQLQSL 527
            :.:.       .|.::.:|..  ||...|..|..||.| .:..||.:. .||.| ..||  :|..
Mouse   582 RGTA-------AGHVVSRVVGWDADAGHNAWLSYSLLGAPNQSLFAVGLHTGQISTARP--IQDT 637

  Fly   528 NESTVHLIAIATDTGVPPRST--SVPVSVTMEGLTLARSGW---------NSNMLGMFGMIMGLF 581
            :.....|..:.:|:|.|..||  ::.||||.|. ..||:.:         |.|:  .|.:::.|.
Mouse   638 DSPRQILTVLISDSGEPLLSTTATLTVSVTEES-PEARAEFPSGSAPREQNKNL--TFYLLLSLI 699

  Fly   582 LM----IIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANLVTHEKLAGNGNGNGAS 642
            |:    .:..|...|.:..|..:|        |:...:...|...:.....|           |.
Mouse   700 LVSVGFAVTVLGVIIFKVYKWKRS--------RDLYRAPVSSLYRTPGPSLH-----------AD 745

  Fly   643 VTSGGVSVLHMKHGGNITMANPMNNGLHHVASGASSSMA-----------------LGSSAALLE 690
            ...||:...|:.|...:|..:..::.|.. ..||:|.:|                 ||:.:|...
Mouse   746 AVRGGLMPPHLYHQVYLTTDSRRSDPLLK-KPGAASPLASRQNTLRSCDPVFYRQVLGAESAPPG 809

  Fly   691 RERERERD---RERQRESYAATVRIFLPGIVSRASANGQLFEEDEIEHDSLQTENNNRKVAATGV 752
            ::.....|   .:.||           ||  :..|.||.  |.....::...||.....:.|:
Mouse   810 QQAPPNTDWRFSQAQR-----------PG--TSGSQNGD--ETGTWPNNQFDTEMLQAMILAS-- 857

  Fly   753 ASGGVTTISTTPANAGSNLLSA 774
            ||......||....||:..|||
Mouse   858 ASEAADGSSTLGGGAGTMGLSA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	20/93 (22%)
		Cadherin_repeat	145..244	CDD:206637	34/105 (32%)
		Cadherin_repeat	253..347	CDD:206637	32/206 (16%)
		Cadherin_repeat	365..452	CDD:206637	28/101 (28%)
		Cadherin_repeat	461..555	CDD:206637	28/100 (28%)
Pcdhgc3	NP_291059.1	Cadherin_2	33..114	CDD:285466	20/96 (21%)
		Cadherin_repeat	139..240	CDD:206637	34/106 (32%)
		Cadherin_repeat	249..348	CDD:206637	16/101 (16%)
		Cadherin_repeat	361..453	CDD:206637	16/91 (18%)
		Cadherin_repeat	461..563	CDD:206637	29/103 (28%)
		Cadherin_repeat	580..667	CDD:206637	26/95 (27%)
		Cadherin_C_2	689..775	CDD:293101	18/107 (17%)
		Cadherin_tail	811..>907	CDD:292596	21/86 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050