DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdhgb7

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_291057.1	Gene:	Pcdhgb7 / 93704	MGIID:	1935199	Length:	929	Species:	Mus musculus

Alignment Length:	669	Identity:	158/669 - (23%)
Similarity:	251/669 - (37%)	Gaps:	207/669 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GSAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNAPVEIHPGTKELALSVELDKEGV 101
            |....:...|:|..||::|||         ..|:.||:.|.:|. ::....::|..||:.:...:
Mouse    30 GQPVRYSIPEELDRGSVVGKL---------AKDLGLSVLEVSAR-KLRVSAEKLHFSVDSESGDL 84

  Fly   102 RGPSSIYVNVICIRRHSTD---------PSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPG 157
            .....|....||..|...:         |..:..|.|.:.||||:|||:......|.:||...||
Mouse    85 LVKDRIDREQICKGRRKCELQLEAVLENPLNIFHVVVEIEDVNDHAPQFPKDEINLEISESDSPG 149

  Fly   158 TR-ILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEGT----LVLKKALDYEQLQNFTV 217
            .| ||:.|:..|.   |..|..:||:.|..|...:...|| :|:    |.|:|.||.|......:
Mouse   150 ARTILESAKDLDI---GMNSLSKYQLSPNDYFLLLVKDNP-DGSKYPELELQKMLDREAESTHHL 210

  Fly   218 KLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEG 282
            .|.|.|.|.|||...|.||:.:.||:|..|.|.::.|...:|.|..||...:|   |||:|||||
Mouse   211 MLTAVDGGDPPRTGTTQLRIRVVDANDNRPVFSQDVYRVRLPEDLPPGTTVLR---LKAMDQDEG 272

  Fly   283 ICAPIQYTIVQSQDAKYFRIHPHNGAISLLTPIGYADVANGATLVVKATQIDNPDRYALTTVQLT 347
            |.|...|:                          :..|||.|             :::|
Mouse   273 INAEFTYS--------------------------FLGVANKA-------------QFSL------ 292

  Fly   348 RPGSHSDLSTLAFVQKRFVMRIREDTAVGNRILALPTNKPGKHLKYVIPDPVNSQFFSVGSLGEL 412
                                                             ||:.         |::
Mouse   293 -------------------------------------------------DPIT---------GDI 299

  Fly   413 VLAKPLDYEKMTKHEFQVLATD-GMTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRAD 476
            |..:.||:|::.::...|.|.| |..:|..::.:||:|.||..|       |.::...|.|...|
Mouse   300 VTRQSLDFEEVEQYTIDVEAKDRGSLSSQCKVIIEVLDENDNRP-------EIIITSLSDQISED 357

  Fly   477 SFEGVLIG--KVEAADGDRNDKLELSLRGQHAGLFEIDSTGNIYMR--------PEQLQSLNEST 531
            |..|.::.  ||...|...|.::..||.|.:.  |:|.|:.|.|.:        .||....|
Mouse   358 SPSGTVVALFKVRDRDSGENAEVMCSLSGNNP--FKIHSSSNNYYKLVTDSILDREQTPGYN--- 417

  Fly   532 VHLIAIATDTGVPPRSTSVPVSVTM------------------------EGLTLAR-SGWNSNML 571
              :...|||.|.||.|:|..:::.:                        .|.::.: ..|:.: :
Mouse   418 --VTITATDRGKPPLSSSTTITLNVADVNDNAPVFQQQAYLINVAENNQPGTSITQVKAWDPD-V 479

  Fly   572 GMFGMIMGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNR--VHSQA---HSSVSSANLVTHEK 631
            |..|::           |..|:.|..:.|:.||.:.:.::.  |::|.   |..:.|..|....:
Mouse   480 GSNGLV-----------SYSIIASDLEPKALSSFVSVNQDSGVVYAQRAFDHEQIRSFQLTLQAR 533

  Fly   632 LAGNGNGNGASVTSGGVSV 650
                  ..|:...|..||:
Mouse   534 ------DQGSPALSANVSM 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	25/99 (25%)
		Cadherin_repeat	145..244	CDD:206637	37/103 (36%)
		Cadherin_repeat	253..347	CDD:206637	22/93 (24%)
		Cadherin_repeat	365..452	CDD:206637	15/87 (17%)
		Cadherin_repeat	461..555	CDD:206637	29/103 (28%)
Pcdhgb7	NP_291057.1	Cadherin_2	32..112	CDD:285466	19/89 (21%)
		Cadherin_repeat	137..238	CDD:206637	37/104 (36%)
		Cadherin_repeat	246..341	CDD:206637	38/200 (19%)
		Cadherin_repeat	353..446	CDD:206637	27/99 (27%)
		Cadherin_repeat	455..556	CDD:206637	19/110 (17%)
		Cadherin_repeat	576..660	CDD:206637
		Cadherin_C_2	685..765	CDD:293101
		Cadherin_tail	806..>902	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050