DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and Cdhr4

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001365320.1	Gene:	Cdhr4 / 69398	MGIID:	1916648	Length:	783	Species:	Mus musculus

Alignment Length:	621	Identity:	136/621 - (21%)
Similarity:	227/621 - (36%)	Gaps:	181/621 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNAPVEIHPGTKELALSVELDKEG-V 101
            :.|.....|.:..|:::..|.:.|...|:   ||::..:..:|...           .:|::| :
Mouse   133 AGEFIYVPETITPGALVYTLLLPGVQRAQ---INITSAQNPSPGPF-----------SIDEQGLL 183

  Fly   102 RGPSSIYVNVICIRRHSTDPSFVIPVN--------------VRVTDVNDNAPQWIGTPYTLTLSE 152
            |.||...       |.....:|.:.::              |:|.....:...::....::|:||
Mouse   184 RAPSQGL-------RGQAQKTFQLQISVSFEKNQSCRGMLTVKVLPAPSSQVSFLQKAQSITISE 241

  Fly   153 VTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEY--------VQFLNPL-----EGTLVLK 204
            ..|||:.:::       .|...|:.:...:.|.|...|        |:...||     :|.:|.|
Mouse   242 DLVPGSEVVR-------VQATGFNLLYEIISPRPSLFYSIGQADGVVRTTAPLDLARVQGAMVTK 299

  Fly   205 ---KALDYEQ-----LQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPAD 261
               :|.:..:     :.:.||.:||.:| .|||....||   :|                :||..
Mouse   300 LQVRAFERPRPWASAVFDLTVSVRAVNQ-WPPRCHPALL---VT----------------QIPET 344

  Fly   262 GRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQDAKYFRIH--PHNGAISLLTPIGYADVANGA 324
            ...|.:.   :.|..||.|.. ..|:.|.:         |.|  |.:.::.|...|
Mouse   345 SLVGTVL---DALTCVDPDSA-GRPLDYQL---------RFHSPPDSASLRLRDRI--------- 387

  Fly   325 TLVVKAT-QIDNP-----DRYALTTVQLTRPGSHSDLSTL-----------AFVQKRFVMRIRED 372
             |.|.|| ..|.|     ...::..|...:|...:::..|           |.|.:.|  |::||
Mouse   388 -LEVNATLDCDTPGACFQHSASILVVDGGQPQMTTEIPVLVMVTPVNEFSPACVPRTF--RVQED 449

  Fly   373 TA----VGNRILALPTNKPGKHLKYVIPDPVNSQFFSVGSL-GELVLAKPLDYEKMTKHEFQVLA 432
            |.    :|: |:....:.|...|:|.|....::  |:|..| |||.|..|||||:...::..:|.
Mouse   450 TGPHTLLGS-IVGTDMDYPRNSLEYYISGGPST--FAVDRLSGELHLLGPLDYEQQRLYKITILL 511

  Fly   433 TD--------GMTNSTAELTLEVIDVND----WEPRFRE-THYEFMVPKSSLQSRADSFEGVLIG 484
            .|        ...:.:..:|:||.||||    .||.|:| |.|..|         ..|.|   :.
Mouse   512 IDHSQDWDLNSHRSGSCTITIEVEDVNDHAPECEPPFQELTIYTPM---------GHSME---VT 564

  Fly   485 KVEAADGDRNDKLELS---LRGQHAGLFEIDSTGNIYMR-------PEQLQSLNESTVHLIAIAT 539
            ||.........:|.||   :.|.....|.:.....:|..       |||     ..|..|:....
Mouse   565 KVSCWIPQEPQRLTLSYSIVGGNSQSRFRLQGAILVYNDTVLGPPWPEQ-----PCTYELLIHVA 624

  Fly   540 DTG--VPPRSTSVPVSVTM---EGLTLARSGWNSNM 570
            |.|  :|..||:..:.|.:   :..|:|.|...|.:
Mouse   625 DVGPSIPHLSTTTTIIVHLVPWKASTVATSTHQSTV 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	17/105 (16%)
		Cadherin_repeat	145..244	CDD:206637	29/119 (24%)
		Cadherin_repeat	253..347	CDD:206637	21/101 (21%)
		Cadherin_repeat	365..452	CDD:206637	30/99 (30%)
		Cadherin_repeat	461..555	CDD:206637	22/105 (21%)
Cdhr4	NP_001365320.1	Cadherin_repeat	236..326	CDD:206637	22/96 (23%)
		Cadherin_repeat	338..434	CDD:206637	24/134 (18%)
		Cadherin_repeat	441..540	CDD:206637	31/103 (30%)
		Cadherin_repeat	555..644	CDD:206637	22/105 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100