DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad96Cb and Pcdhb9

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001102860.1	Gene:	Pcdhb9 / 680047	RGDID:	1596840	Length:	798	Species:	Rattus norvegicus

Alignment Length:	831	Identity:	186/831 - (22%)
Similarity:	312/831 - (37%)	Gaps:	228/831 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRINHQ---WIYYAILSLCWFNKATLGAILDSRCYLEGGGSAESFLA--TEDLAVGSIIGKL--- 57
            :.:|.|   :|:...|.|......|..:||:.   .|.|    ||:|  .:||.:|:  |:|
  Rat    12 IHLNRQVMLFIFMMALVLVCSEATTRYSILEE---TESG----SFVAHLAKDLGLGA--GELAAR 67

  Fly    58 --RINGD-------ANAETGDINLSLREK------------------------------------ 77
              |:..|       .:.||||  |.||||
  Rat    68 SARVVSDDYKQRLLLDPETGD--LILREKLDREELCGSLDPCVLPFQVSLEKPVQYFQGELLIQD 130

  Fly    78 ---------------NAPVEIHPGTK-ELALSVELD------------------------KEGVR 102
                           ..|....|||: .|.|:.:||                        .||.:
  Rat   131 INDHAPEFPDRELLLKIPENSQPGTRFSLKLAQDLDVGNNGLQEYRVSTNPHFHVLTRNNSEGKK 195

  Fly   103 GP-------------SSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVT 154
            .|             :.:.:.:|.:...|...|....|.:.:.|:|||||:::.:||.:.:.|..
  Rat   196 YPELVQDRALDREEQAELSLTLIALDGGSPPRSGTALVRILIIDINDNAPEFVNSPYEVQVLESC 260

  Fly   155 VPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQ---FLNPLEGTLVLKKALDYEQLQNFT 216
            .|.:.||. ..|.||| .|.|.:|.|.:...  |:.:|   .:|...|.:.|||.||:|:::::.
  Rat   261 PPDSPILT-VLARDAD-AGNFGSVSYGLFQA--SDEIQQTFSINETTGDMRLKKKLDFEKIKSYH 321

  Fly   217 VKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAV---- 277
            |::.|.|.|........::.|:  |.:|..|:....|.::.:|.:.        ||.:.::
  Rat   322 VEIEATDGGGLSGRGSVMIEVL--DVNDNAPELTISSLTSSVPENA--------PETIISIFRVG 376

  Fly   278 DQDEG-----ICAPIQ-------------YTIVQSQDAKYFRIHPHNGAISLLTPIGYADVANGA 324
            |:|.|     :|:..:             ||:|............:|..|| ::.:|...:....
  Rat   377 DRDSGENGKAVCSISENLPFILKSTFKNFYTLVTESPLDRESRAEYNITIS-VSDLGTPRLTTQH 440

  Fly   325 TLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTA----VGNRILALPTN 385
            |:.|:.:.|::                    :..||.|..:.|.:||:.:    :|........:
  Rat   441 TITVQVSDIND--------------------NAPAFTQTSYTMFVRENNSPALHIGTISATDADS 485

  Fly   386 KPGKHLKYVIPDPVNSQFFSVGSL------GELVLAKPLDYEKMTKHEFQVLATD---GMTNSTA 441
            ....|:.|.:..|.|.|...|..:      |:|...:.||||.:...||.|.|||   ...:|.|
  Rat   486 GSNAHITYSLLPPQNPQLALVSLISINADNGQLFALRALDYEALQAFEFYVGATDQGSPALSSQA 550

  Fly   442 ELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELS---LRG 503
            .:.:.|:|.||..|...........|.:.|..|| :..|.||.||.|.|.|......||   |:.
  Rat   551 LVHVMVLDDNDNAPFVLYPLQNASAPCTELLPRA-AEPGYLITKVVAVDCDSGQNAWLSFQLLKA 614

  Fly   504 QHAGLFEIDSTGNIYMRPEQLQSLNESTVH-LIAIATDTGVPPRSTSVPVSVTM-EGLT------ 560
            ...|||.: ...|..:|..:|.|..:...| |:.:..|.|.|.||.:|.:.|.: :|.:
  Rat   615 TEPGLFSV-WAHNGEVRTTRLLSERDVPKHRLLLLVKDNGDPARSATVTLHVLLVDGFSQPYLPL 678

  Fly   561 --LARSGWNSN-------MLGMFGMIMGLFLMIIVALSCYI-VRSKKQGKSASSGLGLGRNRVHS 615
              :||:....:       ::.....:..|||:.::   .:: ||..::|:..|.| |......|.
  Rat   679 PEVARNAVQEDDDALTLYLVIALASVSSLFLLSVL---LFVGVRLCRRGREVSLG-GCSIPDGHF 739

  Fly   616 QAH-SSVSSANLVT----HEKLAGNGNGNG------ASVTSGGVSVLHMKH 655
            ..| ..||.|..::    :|......:|.|      ..|.:.|:.::...|
  Rat   740 PGHLVDVSGAGTLSQSYQYEVCLRGDSGTGEFKFLKPMVPNAGIEIMESPH 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	33/191 (17%)
		Cadherin_repeat	145..244	CDD:206637	30/101 (30%)
		Cadherin_repeat	253..347	CDD:206637	18/115 (16%)
		Cadherin_repeat	365..452	CDD:206637	26/99 (26%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
Pcdhb9	NP_001102860.1	Cadherin_2	37..117	CDD:285466	23/90 (26%)
		Cadherin_repeat	145..243	CDD:206637	17/97 (18%)
		Cadherin_repeat	251..348	CDD:206637	30/102 (29%)
		Cadherin_repeat	360..452	CDD:206637	17/120 (14%)
		Cadherin_repeat	460..562	CDD:206637	27/101 (27%)
		Cadherin_repeat	581..669	CDD:206637	29/89 (33%)
		Cadherin_C_2	693..775	CDD:293101	17/85 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4545
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050