DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and pcdh20

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001338645.1	Gene:	pcdh20 / 568796	ZFINID:	ZDB-GENE-091204-115	Length:	833	Species:	Danio rerio

Alignment Length:	795	Identity:	181/795 - (22%)
Similarity:	283/795 - (35%)	Gaps:	217/795 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NKATLGAILDSRCYLEGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLREKNAPVEI 83
            |..||..:|...|..:....|..|...|:...|..||.|..|..|....      |.|:.  :.:
Zfish     2 NWKTLQWVLLLACAGQIHSLALRFSVLEEQEAGLKIGTLSTNYSAPYRL------LNERY--IRV 58

  Fly    84 HPGTKELALSVELDKEGV----RGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGT 144
            ...|.:|.....||:|.:    :.....::|...:..|..    |:|:.:.|.|:|||||.:...
Zfish    59 DEITGDLFTKDRLDRETLCPSHQDGECTFLNTAVVSPHLD----VVPMVIVVNDINDNAPVFERN 119

  Fly   145 PYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEGT--------- 200
            ...|.:.|.|..||..|...:|:|.|.... ..:.|.               |||:
Zfish   120 EIPLRIPEDTSIGTTFLLDDQAQDKDTANN-GLIHYH---------------LEGSNGFFGIRQE 168

  Fly   201 -----LVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRES-YSAEIP 259
                 |:::|.||.|...|:.:.|.|.|:|:.|..:...|.|.:||.||..|:|..:| ..|.:|
Zfish   169 DYGLELIVQKELDRETQDNYFLVLVAVDRGSMPLSATANLSVTVTDVDDNCPEFDDDSPIKAIVP 233

  Fly   260 ADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQ--SQDAK-YFRIHPHNGAISLLTPIGYADVA 321
            ..|..|....:   |||.|:|.|..|.|.::..:  |..|| .|.:..|.|.|||...: :.|..
Zfish   234 GLGIKGTAVAQ---LKATDKDLGQNAQITFSFSRQISDRAKTLFYMDRHTGLISLAVDV-HTDSP 294

  Fly   322 NGATLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFV--QKRFVMRIR-------------E 371
            ....|.|.|.....|...|..||.:....|......:.||  .|..|:.::             |
Zfish   295 EEHMLKVFANGPLCPPAQAQVTVYIQPMVSSEPTIKIRFVTEHKNQVIMLQENEPPTVLALLELE 359

  Fly   372 DTAVGNRILALPT---------------------------------------------------- 384
            ||:.....|:|.|
Zfish   360 DTSSDKGTLSLETDSMPFSLKQQAGSYLLSTSKALDFELCGEYDVTVVISDPHGARLHGREVIKV 424

  Fly   385 ------------------------NKPGKH-LKYVIPDPVNSQFFSV------GS-------LGE 411
                                    ||||:. ||....|..:.||..|      ||       .|.
Zfish   425 VVQDLNDNAPKFEQTRYETDIKENNKPGEFLLKVQATDADSHQFGKVEYRITNGSPFRIQEETGV 489

  Fly   412 LVLAKPLDYEKMTKHEFQVLATDG---MTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQS 473
            :::.:|||.|:...:...|||.||   ...:.|.:.:.|:|:||..|.|...|:.|.| ..||..
Zfish   490 ILVTEPLDREQQGTYILTVLAQDGGDPSQEAFAIVFVNVLDMNDNPPAFPTPHFYFFV-SESLPH 553

  Fly   474 RADSFEGVLIGKV---EAADGDRNDKLELSLRGQHAGLFEIDSTGNIYMRPEQLQSLNESTVHLI 535
            .:.      :|||   :|.|||....::|.:....|. |.||.:..:.....::....:....|:
Zfish   554 LSQ------VGKVTVSDADDGDNGRIVDLRILNDKAP-FVIDMSQGMLRSTGEVDREKQDRYELL 611

  Fly   536 AIATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGMIMGLFLMIIVALSCYIVRSKKQGK 600
            .:|.|.|.|..||:|.::|.:|.:       |.|...:        |:....|||..:....|..
Zfish   612 VVAVDGGSPVLSTTVKMTVFVEDI-------NDNQPQV--------LLPSSNLSCLTISPATQAG 661

  Fly   601 SASSGLGLGRNRVHSQAHSSVSSANLVTHEKLAGNGNGNGASVTSGGVSVLHM-----KHGGNIT 660
            |..:       ::::....|..::: :|::.:|..             ..|..     :|.||||
Zfish   662 SMIT-------KIYAIDEDSGMNSD-ITYQIIASE-------------PALQSPFQIDQHSGNIT 705

  Fly   661 MANPMNN---GLHHV 672
            :...:..   |:||:
Zfish   706 LVQHLRGEDYGMHHL 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	21/94 (22%)
		Cadherin_repeat	145..244	CDD:206637	28/112 (25%)
		Cadherin_repeat	253..347	CDD:206637	30/97 (31%)
		Cadherin_repeat	365..452	CDD:206637	32/192 (17%)
		Cadherin_repeat	461..555	CDD:206637	25/96 (26%)
pcdh20	NP_001338645.1	E_set	22..>77	CDD:324323	16/62 (26%)
		Cadherin_repeat	120..218	CDD:206637	29/113 (26%)
		Cadherin_repeat	239..320	CDD:206637	26/84 (31%)
		Cadherin_repeat	341..432	CDD:206637	7/90 (8%)
		Cadherin_repeat	441..534	CDD:206637	26/92 (28%)
		Cadherin_repeat	542..638	CDD:206637	28/110 (25%)
		Cadherin_repeat	652..743	CDD:206637	14/90 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4620
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050