DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Cb and PCDHA3

DIOPT Version :9

Sequence 1:NP_001287524.1 Gene:Cad96Cb / 43033 FlyBaseID:FBgn0039294 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_061729.1 Gene:PCDHA3 / 56145 HGNCID:8669 Length:950 Species:Homo sapiens


Alignment Length:738 Identity:189/738 - (25%)
Similarity:305/738 - (41%) Gaps:148/738 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 EGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDI-----NLSLREKNAPVEIHPGTKELALS 93
            |.|.....:..:|:...|:.:|  ||..|...|..::     .::.:.....:|::.....|.::
Human    25 EVGSGQLHYSVSEEAKHGTFVG--RIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVN 87

  Fly    94 VELDKEGVRGPS---SIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTV 155
            ..:|:|.:.|.|   ||::.||..|     |..|..|.|.|.|:|||||.:......|.:||...
Human    88 SRIDREELCGRSAECSIHLEVIVDR-----PLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147

  Fly   156 PGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY--------SEYVQFLNPLEGTLVLKKALDYEQ 211
            ||:|. |:|  |.||| .|..|.:.|.:....|        .|.::.|.     |||||.|:.|.
Human   148 PGSRFSLEG--ASDAD-IGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLG-----LVLKKNLNRED 204

  Fly   212 LQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKA 276
            .....:.:.|.|.|.|.....|.|::.:.|.:|..|.|:|..|...:..:...|.|.:   .:.|
Human   205 TPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVV---TVNA 266

  Fly   277 VDQDEGICAPIQYTIVQSQDA---KYFRIHPHNGAISLLTPIGYADVANGATLVVKATQIDNPDR 338
            .|.|||:...|.|:......|   ..|.:.|.||.||:...|.:.: :....:.|:||...||..
Human   267 TDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEE-SKSYEIQVEATDKGNPPM 330

  Fly   339 YALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGN--RILALPTNKPGKH------LKYVI 395
            ....||.|.....:.::..|  |.:...:.:.||:.:..  .::::.....|.:      |...:
Human   331 SDHCTVLLEIVDINDNVPEL--VIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHV 393

  Fly   396 PDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS---TAELTLEVIDVNDWEPRF 457
            |..:.|.|.:..|   |||..|||.|.::.:|..|.|.||.:.|   ||.:::||.||||..|.|
Human   394 PFKLVSTFKNYYS---LVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF 455

  Fly   458 RETHYEFMVPKS--------SLQSR-ADSFEGVLI--GKVEAADGDRNDKLELSLRGQHAGLFEI 511
            .::.|...|.::        ::.:| ||:.|..|:  ..||...|:|.....:|:   ||     
Human   456 SQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV---HA----- 512

  Fly   512 DSTGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSV-------TMEGLTLARSGW 566
             .:|.:|    .||.|:...:.|:..   |.|.||||..::|.:.|       ....|.:.|.| 
Human   513 -ESGKVY----ALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVG- 571

  Fly   567 NSNMLGMFGMIMGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANL-VTHE 630
                 |:.|           |:|..:.||          :|.|......:|..:.|..|. :::|
Human   572 -----GIGG-----------AVSELVPRS----------VGAGHVVAKVRAVDADSGYNAWLSYE 610

  Fly   631 KLAGNGNGNGASVT------SGGVS----------------VLHMKHG-GNIT-----MANPMNN 667
            ...|.|   ||.:.      :|.:|                ||...|| .::|     :.:.:.:
Human   611 LQPGTG---GARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVES 672

  Fly   668 GLHHVASGASSSMALGSSAALLE 690
            |....||..:|:.|.|..|||::
Human   673 GQAPKASSQASAGATGPEAALVD 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CbNP_001287524.1 Cadherin_repeat 46..137 CDD:206637 25/98 (26%)
Cadherin_repeat 145..244 CDD:206637 32/107 (30%)
Cadherin_repeat 253..347 CDD:206637 25/96 (26%)
Cadherin_repeat 365..452 CDD:206637 27/97 (28%)
Cadherin_repeat 461..555 CDD:206637 28/114 (25%)
PCDHA3NP_061729.1 Cadherin_2 30..111 CDD:285466 17/82 (21%)
Cadherin_repeat 139..238 CDD:206637 32/106 (30%)
Cadherin_repeat 246..346 CDD:206637 26/103 (25%)
Cadherin_repeat 354..451 CDD:206637 28/99 (28%)
Cadherin_repeat 459..561 CDD:206637 28/114 (25%)
Cadherin_repeat 581..670 CDD:206637 19/101 (19%)
6 X 4 AA repeats of P-X-X-P 734..894
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 777..806
Cadherin_tail 799..942 CDD:292596
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 831..856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..950
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 131 1.000 Inparanoid score I4632
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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