Protein Alignment Cad96Cb and PCDHA3

DIOPT Version :10

• Sequence 1: NP_001287524.1
• Gene: Cad96Cb / 43033
• FlyBaseID: FBgn0039294
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_061729.1
• Gene: PCDHA3 / 56145
• HGNCID: 8669
• Length: 950
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 189/738 - (25%)
• Similarity: 305/738 - (41%)
• Gaps: 148/738 - (20%)

  Fly    34 EGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDI-----NLSLREKNAPVEIHPGTKELALS 93
            |.|.....:..:|:...|:.:|  ||..|...|..::     .::.:.....:|::.....|.::
Human    25 EVGSGQLHYSVSEEAKHGTFVG--RIAQDLGLELAELVPRLFRVASKRHGDLLEVNLQNGILFVN 87

  Fly    94 VELDKEGVRGPS---SIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTV 155
            ..:|:|.:.|.|   ||::.||..|     |..|..|.|.|.|:|||||.:......|.:||...
Human    88 SRIDREELCGRSAECSIHLEVIVDR-----PLQVFHVEVEVKDINDNAPVFPMAVKNLFISESRQ 147

  Fly   156 PGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY--------SEYVQFLNPLEGTLVLKKALDYEQ 211
            ||:|. |:|  |.||| .|..|.:.|.:....|        .|.::.|.     |||||.|:.|.
Human   148 PGSRFSLEG--ASDAD-IGTNSLLTYSLDSTEYFTLDVKRNDEEIKSLG-----LVLKKNLNRED 204

  Fly   212 LQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKA 276
            .....:.:.|.|.|.|.....|.|::.:.|.:|..|.|:|..|...:..:...|.|.:   .:.|
Human   205 TPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKVRLLENAPNGTLVV---TVNA 266

  Fly   277 VDQDEGICAPIQYTIVQSQDA---KYFRIHPHNGAISLLTPIGYADVANGATLVVKATQIDNPDR 338
            .|.|||:...|.|:......|   ..|.:.|.||.||:...|.:.: :....:.|:||...||..
Human   267 TDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEE-SKSYEIQVEATDKGNPPM 330

  Fly   339 YALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGN--RILALPTNKPGKH------LKYVI 395
            ....||.|.....:.::..|  |.:...:.:.||:.:..  .::::.....|.:      |...:
Human   331 SDHCTVLLEIVDINDNVPEL--VIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHV 393

  Fly   396 PDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATDGMTNS---TAELTLEVIDVNDWEPRF 457
            |..:.|.|.:..|   |||..|||.|.::.:|..|.|.||.:.|   ||.:::||.||||..|.|
Human   394 PFKLVSTFKNYYS---LVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAF 455

  Fly   458 RETHYEFMVPKS--------SLQSR-ADSFEGVLI--GKVEAADGDRNDKLELSLRGQHAGLFEI 511
            .::.|...|.::        ::.:| ||:.|..|:  ..||...|:|.....:|:   ||
Human   456 SQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSV---HA----- 512

  Fly   512 DSTGNIYMRPEQLQSLNESTVHLIAI---ATDTGVPPRSTSVPVSV-------TMEGLTLARSGW 566
             .:|.:|    .||.|:...:.|:..   |.|.||||..::|.:.|       ....|.:.|.|
Human   513 -ESGKVY----ALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVG- 571

  Fly   567 NSNMLGMFGMIMGLFLMIIVALSCYIVRSKKQGKSASSGLGLGRNRVHSQAHSSVSSANL-VTHE 630
                 |:.|           |:|..:.||          :|.|......:|..:.|..|. :::|
Human   572 -----GIGG-----------AVSELVPRS----------VGAGHVVAKVRAVDADSGYNAWLSYE 610

  Fly   631 KLAGNGNGNGASVT------SGGVS----------------VLHMKHG-GNIT-----MANPMNN 667
            ...|.|   ||.:.      :|.:|                ||...|| .::|     :.:.:.:
Human   611 LQPGTG---GARIPFRVGLYTGEISTTRALDEVDAPRHRLLVLVKDHGEPSLTATATVLVSLVES 672

  Fly   668 GLHHVASGASSSMALGSSAALLE 690
            |....||..:|:.|.|..|||::
Human   673 GQAPKASSQASAGATGPEAALVD 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	CA_like	<80..139	CDD:481204	20/61 (33%)
		Cadherin_repeat	145..244	CDD:206637	32/107 (30%)
		Cadherin_repeat	253..347	CDD:206637	25/96 (26%)
		Cadherin_repeat	365..452	CDD:206637	27/97 (28%)
		Cadherin_repeat	461..555	CDD:206637	28/114 (25%)
PCDHA3	NP_061729.1	Cadherin_2	30..111	CDD:462413	17/82 (21%)
		Cadherin_repeat	139..238	CDD:206637	32/106 (30%)
		Cadherin_repeat	246..346	CDD:206637	26/103 (25%)
		Cadherin_repeat	354..451	CDD:206637	28/99 (28%)
		Cadherin_repeat	459..561	CDD:206637	28/114 (25%)
		Cadherin_repeat	581..670	CDD:206637	19/101 (19%)
		6 X 4 AA repeats of P-X-X-P	734..894
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..806
		Cadherin_tail	800..916	CDD:435046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	831..856
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..950