DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and PCDHB7

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_061763.1	Gene:	PCDHB7 / 56129	HGNCID:	8692	Length:	793	Species:	Homo sapiens

Alignment Length:	585	Identity:	149/585 - (25%)
Similarity:	246/585 - (42%)	Gaps:	91/585 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILSLCWFNKATLGAILDSRCYLEGGGSAESFLA--TEDLAVGSIIGKLRINGDANAETGDINLSL 74
            :|.||.|...:.......|.::.......:||.  .:||.:|  :|:||..|.......::.:.|
Human    14 VLFLCVFLGMSWAGAEPLRYFVAEETERGTFLTNLAKDLGLG--VGELRARGTRIVSDQNMQILL 76

  Fly    75 REKNAPVEIHPGTKELALSVELDKEGVRGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDVNDNAP 139
                    :...|.:|.|:.:||:|.:.||..  ..|:..:.....|..:....:.|.|:||:||
Human    77 --------LSSLTGDLLLNEKLDREELCGPRE--PCVLPFQLLLEKPFQIFRAELWVRDINDHAP 131

  Fly   140 QWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGPYSEYVQFLNPLEGT---- 200
            .::....:|.:.|.|.||...|..: |:|:| .|..|...|.:.|..|. ::...:..||.
Human   132 VFLDREISLKILESTTPGAAFLLES-AQDSD-VGTNSLSNYTISPNAYF-HINVHDSGEGNIYPE 193

  Fly   201 LVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPG 265
            |||.:.||.|::..|::.|.|.|.|:|||....|:|:::.|.:|..|.|.|..|..::|.:...|
Human   194 LVLNQVLDREEIPEFSLTLTALDGGSPPRSGTALVRILVLDVNDNAPDFVRSLYKVQVPENSPVG 258

  Fly   266 ELRMRPEPLKAVDQDEGICAPIQYTIVQSQD--AKYFRIHPHNGAISLLTPIGY----------- 317
            .:.:   .:.|.|.|.|....|.|....:.:  .|.|:|:|.:|::.|...:.|
Human   259 SMVV---SVSARDLDTGSNGEIAYAFSYATERILKTFQINPTSGSLHLKAQLDYEAIQTYTLTIQ 320

  Fly   318 ----ADVANGATLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIREDTAVGNR 378
                ..::...|:||..|.| |.:|..|....||.|.:.:...|:..|   |.:|.|:....|..
Human   321 AKDGGGLSGKCTVVVDVTDI-NDNRPELLLSSLTSPIAENSPETVVAV---FRIRDRDSGNNGKT 381

  Fly   379 ILALPTNKPGKHLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD-GMTNSTAE 442
            :.::..:.|      .|..|....|::      ||..||||.|:.|::...:..|| |......|
Human   382 VCSIQDDVP------FILKPSVENFYT------LVTEKPLDRERNTEYNITITVTDLGTPRLKTE 434

  Fly   443 --LTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELSLRGQH 505
              :|:.|.||||..|.|.:|.|...|       |.::...:.||.|.|.|.|.....::
Human   435 HNITVLVSDVNDNAPAFTQTSYTLFV-------RENNSPALPIGSVSATDRDSGTNAQV------ 486

  Fly   506 AGLFEIDSTGNIYMRPEQLQSLNESTVHLIAI----------------ATDTGVPPRSTSVPVSV 554
              ::.:..:.:.::....|.|:|....||.|:                |||.|.|..|:...|.|
Human   487 --IYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRV 549

Fly 555 554
Human 550 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	21/90 (23%)
		Cadherin_repeat	145..244	CDD:206637	33/102 (32%)
		Cadherin_repeat	253..347	CDD:206637	24/110 (22%)
		Cadherin_repeat	365..452	CDD:206637	24/89 (27%)
		Cadherin_repeat	461..555	CDD:206637	23/110 (21%)
PCDHB7	NP_061763.1	Cadherin_2	30..112	CDD:285466	20/93 (22%)
		Cadherin_repeat	137..238	CDD:206637	33/103 (32%)
		Cadherin_repeat	247..343	CDD:206637	22/99 (22%)
		Cadherin_repeat	356..447	CDD:206637	27/105 (26%)
		Cadherin_repeat	455..557	CDD:206637	23/110 (21%)
		Cadherin_repeat	576..664	CDD:206637
		Cadherin_C_2	683..766	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4632
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960