Protein Alignment Cad96Cb and PCDHB13

DIOPT Version :9

• Sequence 1: NP_001287524.1
• Gene: Cad96Cb / 43033
• FlyBaseID: FBgn0039294
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_061756.1
• Gene: PCDHB13 / 56123
• HGNCID: 8684
• Length: 798
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 163/746 - (21%)
• Similarity: 272/746 - (36%)
• Gaps: 220/746 - (29%)

  Fly    33 LEGGGSAESFLATEDLAVGSIIGKLRINGDANAETGDINLSLRE------------KNAPVEIHP 85
            |.|.....|:...|:....|.:..|         ..|:.|..||            ....::::.
Human    25 LAGAAEPRSYSVVEETEGSSFVTNL---------AKDLGLEQREFSRRGVRVVSRGNKLHLQLNQ 80

  Fly    86 GTKELALSVELDKEGVRGPSSIYVNVICIRRHST---DPSFVIPVNVRVTDVNDNAPQWIGTPYT 147
            .|.:|.|:.:||:|.:.|.:.     .|:.|...   .|.......::|.|:||::|.::.....
Human    81 ETADLLLNEKLDREDLCGHTE-----PCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQML 140

  Fly   148 LTLSEVTVPGTRI-LQGARAEDADQPGPFSTVEYQVLPGPY-----------SEYVQFLNPLEGT 200
            :.:||.:.|||.. |:  .|||.| .|..:...|.:.|..|           .:|.:
Human   141 VKVSESSPPGTTFPLK--NAEDLD-VGQNNIENYIISPNSYFRVLTRKRSDGRKYPE-------- 194

  Fly   201 LVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIPADGRPG 265
            |||.||||.|:.....:.|.|.|.|:|||.....:.:.:.|.:|..|:|::..|..:|..|...|
Human   195 LVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPVG 259

  Fly   266 ELRMRPEPLKAVDQDEGICAPIQYTIVQSQD--AKYFRIHPHNGAISLLTPIGY----------- 317
            .|.::   :.|.|.|.|:...|.|::.|:.:  .|.|:|:|..|.|.|...:.:
Human   260 FLVVK---VSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIE 321

  Fly   318 ---ADVANG-ATLVVKATQIDN--------------PDRYALTTVQL------------------ 346
               |...:| .|::::...:::              |:....|.|.|
Human   322 ARDAGTFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSI 386

  Fly   347 -------------------TRPGSH------------SDLST--------------------LAF 360
                               .||...            :||.|                    .||
Human   387 QEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDNAPAF 451

  Fly   361 VQKRFVMRIREDTAVGNRILALPTNKPGKHLKYV-----------------IPD-----PVNSQF 403
            .|..:.:.:||:            |.|..|::.|                 :|.     |:.|..
Human   452 TQTSYTLFVREN------------NSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLV 504

  Fly   404 FSVGSLGELVLAKPLDYEKMTKHEFQVLATD---GMTNSTAELTLEVIDVNDWEPRFRETHYEFM 465
            ......|.|...:.||||.:...:|:|.|:|   ...:|.|.:.:.|:|.||..|..........
Human   505 SINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNGS 569

  Fly   466 VPKSSLQSRADSFEGVLIGKVEAADGDRNDKLELS---LRGQHAGLFEIDSTGNIYMRPEQLQSL 527
            .|.:.|..|| :..|.|:.||.|.|||......||   |:....|||.: ...|..:|..:|.|.
Human   570 APCTELVPRA-AEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGV-WAHNGEVRTARLLSE 632

  Fly   528 NESTVH-LIAIATDTGVPPRSTSVPVSVTM-EGLT--------LARSGWNSNMLGMF-----GMI 577
            .::..| |:.:..|.|.||||.:..:.|.: :|.:        .|.:...:::|.::     ..:
Human   633 RDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQAQADLLTVYLVVALASV 697

  Fly   578 MGLFL---MIIVALSCYIVRSKKQGKSASSG 605
            ..|||   ::.||     ||..::.::||.|
Human   698 SSLFLFSVLLFVA-----VRLCRRSRAASVG 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	20/105 (19%)
		Cadherin_repeat	145..244	CDD:206637	31/110 (28%)
		Cadherin_repeat	253..347	CDD:206637	26/161 (16%)
		Cadherin_repeat	365..452	CDD:206637	23/111 (21%)
		Cadherin_repeat	461..555	CDD:206637	30/97 (31%)
PCDHB13	NP_061756.1	Cadherin_2	31..112	CDD:285466	17/94 (18%)
		Cadherin_repeat	141..239	CDD:206637	31/108 (29%)
		Cadherin_repeat	248..344	CDD:206637	22/98 (22%)
		Cadherin_repeat	357..447	CDD:206637	9/89 (10%)
		Cadherin_repeat	455..557	CDD:206637	24/113 (21%)
		Cadherin_repeat	576..664	CDD:206637	29/89 (33%)
		Cadherin_C_2	686..768	CDD:293101	11/43 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4632
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050