DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad96Cb and PCDHGA4

DIOPT Version :9

Sequence 1:NP_001287524.1 Gene:Cad96Cb / 43033 FlyBaseID:FBgn0039294 Length:789 Species:Drosophila melanogaster
Sequence 2:NP_061740.2 Gene:PCDHGA4 / 56111 HGNCID:8702 Length:962 Species:Homo sapiens


Alignment Length:591 Identity:140/591 - (23%)
Similarity:253/591 - (42%) Gaps:101/591 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ILSLCWFNKATLGAILDSRCYLEGGGSAESFLAT--EDLAVGSIIGKLRIN-GDANAETGD--IN 71
            :|.:|    ..||.:::.|        ||..|.:  |:...||::|.:..: |.|..|..:  :.
Human    44 LLQIC----LLLGVLVEIR--------AEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVR 96

  Fly    72 LSLREKNAPVEIHPGTKELALSVELDKEGV--RGPSSIYVNVICIRRHSTDPSFVIPVNVRVTDV 134
            :..|.:.....::|.:..|..:..:|:|.:  |.|:.:....|.:.    |...::.|.|.:.||
Human    97 IVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLE----DTVKILRVEVEIIDV 157

  Fly   135 NDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQV-LPGPYSEYVQFLNPLE 198
            |||.|.:......:.::|...||.| .....|.|.| .|..|...||: ..|.:|..||  :..:
Human   158 NDNPPSFGTEQREIKVAENENPGAR-FPLPEAFDPD-VGVNSLQGYQLNSNGYFSLDVQ--SGAD 218

  Fly   199 G----TLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVITDADDQNPKFQRESYSAEIP 259
            |    .|||::|||.|:.....:.|.|.|.|.|.|.....:.:::.|.:|..|.|.:..|...:.
Human   219 GIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVR 283

  Fly   260 ADGRPGELRMRPEPLKAVDQDEGICAPIQYTI--VQSQDAKYFRIHPHNGAISLLTPIGYADV-- 320
            .:...|   .|...:||.|.|||....:.|:.  |:.:.::.|:::..:|.|::|..:.|.|.  
Human   284 ENVPVG---TRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGF 345

  Fly   321 --------------ANGATLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFVQKRFVMRIRE 371
                          |....||....:.||.....:|::..:...|.|..:.:|      :..:.:
Human   346 YDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIA------LFNVHD 404

  Fly   372 DTAVGNRIL--ALPTNKPGKHLKYVIPDPVNSQFFSVGSLGELVLAKPLDYEKMTKHEFQVLATD 434
            ..:.||.::  ::|.|.|....|            :.|:...|:..:.||.|:::::...|.|||
Human   405 SDSGGNGLVTCSIPDNLPFTLEK------------TYGNYYRLLTHRTLDREEVSEYNITVTATD 457

  Fly   435 GMT---NSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKVEAADGDRNDK 496
            ..|   ::...::|:|:|:||..|.|....|...:|:::.:       |..|..:.|.|.|..|.
Human   458 QGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPR-------GASILSMTAQDPDSGDN 515

  Fly   497 LEL-------SLRGQHAGLF-EIDS-TGNIY----MRPEQLQSLNESTVHLIAIATDTGVPPRST 548
            ..:       :.:|.....: .|:| ||.:|    ...||.:.|     .|:..|:|:|.||.|:
Human   516 ARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDL-----QLLMTASDSGDPPLSS 575

  Fly   549 SVPVSV 554
            :|.:|:
Human   576 NVSLSL 581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad96CbNP_001287524.1 Cadherin_repeat 46..137 CDD:206637 21/95 (22%)
Cadherin_repeat 145..244 CDD:206637 30/103 (29%)
Cadherin_repeat 253..347 CDD:206637 23/111 (21%)
Cadherin_repeat 365..452 CDD:206637 19/91 (21%)
Cadherin_repeat 461..555 CDD:206637 26/107 (24%)
PCDHGA4NP_061740.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Cadherin_2 61..143 CDD:311943 16/85 (19%)
Cadherin_repeat 170..269 CDD:206637 30/102 (29%)
Cadherin_repeat 277..374 CDD:206637 20/99 (20%)
Cadherin_repeat 386..479 CDD:206637 23/110 (21%)
Cadherin_repeat 487..589 CDD:206637 26/107 (24%)
Cadherin_repeat 610..697 CDD:206637
Cadherin_C_2 720..803 CDD:318652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 832..871
Cadherin_tail 841..>935 CDD:318236
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..962
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 131 1.000 Inparanoid score I4632
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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