DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad96Cb and pcdh1g30

DIOPT Version :9

Sequence 1:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001019297.2	Gene:	pcdh1g30 / 554014	ZFINID:	ZDB-GENE-050609-23	Length:	949	Species:	Danio rerio

Alignment Length:	802	Identity:	177/802 - (22%)
Similarity:	309/802 - (38%)	Gaps:	199/802 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIYYAILSLCWFNKATLGAILDSRCYLEGGGSAESFLATEDLAVGSIIG---------------- 55
            |::  ..||.|   :|:||.:             .:...|:|..||::|
Zfish    15 WLF--AFSLLW---STIGAQI-------------RYTIPEELKEGSVVGNIAKDLGFDISDIAER 61

  Fly    56 KLRINGDANAETGDINLSLREKNAPVEIHPGTKELALSVELDKEGVRGPSS---IYVNVIC---I 114
            ||||..::|.:...::|             |..:|.::..:|:|.:.|.||   :.:.::.   :
Zfish    62 KLRIASESNRQYFSVDL-------------GKGDLLVNGRIDRETLCGQSSGCLMSIQIVIENPL 113

  Fly   115 RRHSTDPSFVIPVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTR-ILQGARAEDADQPGPFSTV 178
            :.||        |.:.:.|:|||||.:.....||.:||:..|||| ||:.  |||.| .|..|..
Zfish   114 QMHS--------VEIEIQDINDNAPNFHTKDATLKISELIAPGTRFILES--AEDLD-VGSNSLK 167

  Fly   179 EYQVLPGPYSEYVQFLNPLEG----TLVLKKALDYEQLQNFTVKLRAQDQGTPPRHSDTLLRVVI 239
            .|.:....|.. :...|..:|    .||::|.||.|:.....:.|.|.|.|.|.:...::|::.:
Zfish   168 TYSLSNNNYFR-LNVKNLKDGRIGPELVVEKPLDREKQSMHKLILTALDGGNPVKSGTSVLQIAV 231

  Fly   240 TDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQDAKY----F 300
            .|.:|..|||:..:|.|.|......|...::   :||.|.|||:...||| ::.:...::    |
Zfish   232 QDINDNEPKFELSAYKASILETAITGSNVLK---IKATDLDEGLNGEIQY-LLSAHTPEFVRNVF 292

  Fly   301 RIHPHNGAISLLTPIGYADVANGATLVVKATQIDNPDRYALTTVQLTRPGSHSDLSTLAFVQKRF 365
            .::...|.|::...:.| :........|.|....||:....::||:.....:.:...:  :....
Zfish   293 SVNADTGEITVTGTLDY-ETKKSYAFDVCAKDKGNPELEGQSSVQIDIIDENDNAPEI--ILTSL 354

  Fly   366 VMRIREDTAVGNRILALPTNKP------GKHLKYVIPD------PVNSQFFSVGSLGELVLAKPL 418
            ...:.|:..||. ::||.|.|.      ||....|.||      |.::.:       .|:....|
Zfish   355 PSPVPENATVGT-VVALITVKDLDSGDNGKVDLIVSPDVPFKLKPFHNHY-------SLITDSLL 411

  Fly   419 DYEKMTKHEFQVLATDG---MTNSTAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEG 480
            |.|...::..:::|.|.   ...:...:.::|:|.||..|.|.:|.|...:.:::|       .|
Zfish   412 DREVRPEYNVEIIAMDSGVPPIKTAKTVNIKVLDTNDNSPLFSQTSYNVYINENNL-------AG 469

  Fly   481 VLIGKVEAADGDRNDKLELSLRGQHAGLFEIDSTGNIYMRPEQ-----LQSLNESTVHLIAI--- 537
            ..:..|.|:|.|.|....|:.....:|...:.::...|:..|.     :.:.:...|.|.::
Zfish   470 ASLFSVSASDIDLNKNAFLTYSILDSGSNYVPASSYFYINSENGSIYCMSTFDYEKVKLFSVVVQ 534

  Fly   538 ATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGMIMGLFLMIIVALSCYIVRSKKQGKSA 602
            |.|.|.|..|::..|.|.:       ...|.|...          :|..:.|...|..::..:|.
Zfish   535 AKDQGSPSLSSNATVHVFI-------LDQNDNAPA----------VIYPSTSMGSVSQQRMPRST 582

  Fly   603 SSG----------LGLGRN-----RVHSQAHSSVSSANLVTHEKLAGNGNGNGASVTSGGVS--- 649
            .:|          ...|.|     |:.....:|:.|.||.|           |...|...||
Zfish   583 KAGHLVTKVTAVDADSGHNAWLFYRLAEATDTSLFSVNLHT-----------GEVRTKRAVSEHD 636

  Fly   650 ------VLHMKHGG------NITMANPMNNGLHHVASGASSSMALGSSAALLERERERERDRERQ 702
                  |:.:|..|      .:|:...:.:|.|...|..                  ||:..|..
Zfish   637 DSSQRLVIEIKDNGEPIQSTTVTVDILIEDGFHEPISDF------------------REKTIEPN 683

  Fly   703 RESYAATVRIFLPGIVSRASAN 724
            |:|...|:.:    |:|.||.:
Zfish   684 RKSGKITLYL----IISLASVS 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	23/112 (21%)
		Cadherin_repeat	145..244	CDD:206637	33/103 (32%)
		Cadherin_repeat	253..347	CDD:206637	23/97 (24%)
		Cadherin_repeat	365..452	CDD:206637	21/101 (21%)
		Cadherin_repeat	461..555	CDD:206637	20/101 (20%)
pcdh1g30	NP_001019297.2	Cadherin_2	29..111	CDD:311943	18/107 (17%)
		Cadherin_repeat	138..237	CDD:206637	33/102 (32%)
		Cadherin_repeat	246..345	CDD:206637	23/103 (22%)
		Cadherin_repeat	358..449	CDD:206637	22/98 (22%)
		Cadherin_repeat	457..559	CDD:206637	22/115 (19%)
		Cadherin_repeat	579..666	CDD:206637	18/97 (19%)
		Cadherin_C_2	689..785	CDD:318652	5/17 (29%)
		Cadherin_tail	816..935	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	130	1.000	Inparanoid score	I4620
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050